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In this study, a multivariate 23 experimental design was applied to optimize the operational conditions (seed mass, salt concentration, and pH) to employ Ceratonia siliqua L. (carob) and Moringa oleifera Lam (moringa) as coagulating/flocculating agents for water treatment. Currently, the coagulation stage in water treatment uses aluminium compounds, due to the characteristic reaction to natural alkalinity in raw water, and for its low market value. Considering that aluminium effects on human health are not sufficiently studied to acknowledge its toxicity, and its significant environmental impacts, it is suitable for the studies to search for alternatives to be employed in the water treatment that will be distributed to human consumption. This study was carried out with raw water of high turbidity level, 83.7 NTU. The raw water collected was also characterized according to pH, colour, Total Organic Carbon (TOC), Dissolved Organic Carbon (DOC), and Dissolved Organic Matter (DOM), with values of 6.7, 178 NTU, 6.80, 2.45 and 138.58 mg/L, respectively. The optimized results showed that with 2 g of seed, 0.5 mol L-1 of NaCl, and pH 11.0 In these conditions, moringa coagulant reached 90%, 86%, 6%, 67%, and 81% for turbidity, colour, DOC, TOC, and DOM removal, respectively, whereas the carob coagulant achieved 85%, 76%, 5%, 55.6%, 66.7%, respectively for the same parameters' removal. Both coagulants presented lower sludge formation, 1.1 mL L-1 for moringa coagulant, and 1.1 mL L-1 for carob coagulant. The results could be considered promises, and natural polymers carob and moringa can be suggested as alternatives agents in coagulation/flocculation stages for water treatment.The SARS-CoV-2 B.1.1.7 lineage is highly infectious and as of April 2021 accounted for 92% of COVID-19 cases in Europe and 59% of COVID-19 cases in the U.S. [https://www.selleckchem.com/products/linderalactone.html Linderalactone manufacturer] It is defined by the N501Y mutation in the receptor-binding domain (RBD) of the Spike (S) protein, and a few other mutations. These include two mutations in the N terminal domain (NTD) of the S protein, HV69-70del and Y144del (also known as Y145del due to the presence of tyrosine at both positions). We recently identified several emerging SARS-CoV-2 variants of concerns, characterized by Membrane (M) protein mutations, including I82T and V70L. We now identify a sub-lineage of B.1.1.7 that emerged through sequential acquisitions of MV70L in November 2020 followed by a novel SD178H mutation first observed in early February 2021. The percentage of B.1.1.7 isolates in the US that belong to this sub-lineage increased from 0.15% in February 2021 to 1.8% in April 2021. To date, this sub-lineage appears to be U.S.-specific with reported cases in 31 states, including Hawaii. As of April 2021, it constituted 36.8% of all B.1.1.7 isolates in Washington. Phylogenetic analysis and transmission inference with Nextstrain suggest this sub-lineage likely originated in either California or Washington. Structural analysis revealed that the SD178H mutation is in the NTD of the S protein and close to two other signature mutations of B.1.1.7, HV69-70del and Y144del. It is surface exposed and may alter NTD tertiary configuration or accessibility, and thus has the potential to affect neutralization by NTD directed antibodies.<br /><br /> The aim of the present study was to identify the habitual dietary intake and stress fractures history among sport types and to determine the factors related to the risk of stress fractures among Japanese female collegiate athletes.<br /><br /> This study involved 589 Japanese female collegiate athletes. We investigated habitual dietary intake (food frequency questionnaire), eating attitude (EAT-26), demographics, training status, participation in sports events, history of injury in their career, and menstrual status using a self-reported questionnaire. A multivariate logistic regression analysis was conducted to determine the risk factors associated with stress fractures.<br /><br /> Thirty percent of the total participants had a history of stress fractures, although most participants had no risk of eating disorders. Most Japanese female collegiate athletes consumed less than the dietary reference intake levels for the general Japanese female population aged 18-29 years and the athletes' dietary guideline for key bone-health nutrients such as calcium and vitamin D. The multivariate logistic regression analysis revealed body mass index (BMI; OR, 0.91; 95% CI, 0.82-0.99) and energy intake (EI; OR, 0.99; 95% CI, 0.99-0.99) as significant and independent factors in the history of stress fractures among Japanese female collegiate athletes (<br /><br />  = 0.047 and <br /><br />  = 0.039, respectively).<br /><br /> Japanese female collegiate athletes failed to meet energy and nutrient recommendations; BMI and EI were significantly associated with stress fractures, a diet that includes an appropriate amount of energy is essential.<br /><br />Japanese female collegiate athletes failed to meet energy and nutrient recommendations; BMI and EI were significantly associated with stress fractures, a diet that includes an appropriate amount of energy is essential.The researchers evaluated the association between hyperuricemia and metabolic risk components in Korean women of reproductive and postmenopausal ages. The study data were collected from the Korea National Health and Nutrition Examination Survey 2016. Among a total of 4305 female participants, the data of 2958 women were analyzed. Of the 2958 participants, 57.6% (n = 1508) were of reproductive age. After adjusting for factors, hyperuricemia was significantly associated with abdominal obesity (OR 4.30, p = .046), high blood pressure (OR 3.23, p = .002), and hypertriglyceridemia (OR 3.08, p = .005) in reproductive women. In contrast, no metabolic risk was significantly associated with hyperuricemia in postmenopausal women.Multiple alleles were constantly detected in Alternaria solani isolates by simple sequence repeat (SSR) analysis, and sectors were also observed in their subcultures. These preliminary results and observations point to a possible parasexual cycle in A. solani. In this study, codominant SSR markers were used as molecular markers on the chromosomes of A. solani and single-conidium subculture was used to simulate the mitosis process of A. solani in nature. The number of alleles at locus As-95236 changed from 2 to 1 as a molecular marker for haploidy of parasexuality of A. solani. Fifty monosporic F1 strains were tested. The results showed that two parent strains lost allele with a haploid probability of 38%. For F2 strains, the results showed that all four F1 strains lost allele with a haploid probability of 75%. Since sexual recombination of A. solani has not been found so far, the allele lost in the subcultures of A. solani isolates provides molecular evidence for the existence of parasexual reproduction in A.