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Administration of 4 GBq or more in patients aged 61-71 years results in 4-fold increase of the risk of severe tearing. Dry mouth causes 3.6-fold increase of the risk of developing severe tearing.Conclusion Finding risk factors for SALDO development after radioiodine therapy in the future will contribute to an individualized approach to the prevention of this complication. Development of preventive measures is one of the tasks facing researchers.Salinity is a widespread soil and underground water contaminant threatening food security and economic stability. Phytoremediation is an efficient and environmental-friendly solution to mitigate salinity impacts. The present study was conducted to evaluate the phytoremediation potential of five multipurpose trees Vachellia nilotica, Concorpus erectus, Syzygium cumini, Tamarix aphylla and Eucalyptus cammaldulensis under four salinity treatments Control, 10, 20 and 30 dS m-1. Salinity negatively impacted all the tested species. However, E. cammaldulensis and T. aphylla exhibited the lowest reduction (28%) and (35%) in plant height respectively along with a minimal reduction in leaf gas exchange while V. nilotica, S. cumini and C. erectus showed severe dieback. Similarly, the antioxidant enzymes increased significantly in E. cammaldulensis and T. aphylla as Superoxide Dismutase (87% and 79%), Catalase (66% and 67%) and Peroxidase (89% and 81%), respectively. Furthermore, both of these species maintained optimum Na/K ratio reducing the highest levels of soil ECe and SAR, suggesting the best phytoremediation potential. The present study identifies that E. cammaldulensis and T. aphylla showed effective tolerance mechanisms and the highest salt sequestration; therefore, may be used for phyto-amelioration of salinity impacted lands. Novelty statement Although previous studies evaluated the tolerance potential of many tree species, comparative and physiochemical evaluation of multipurpose tree species has been remained unexplored. In this scenario, eco-physiological characterization of multipurpose tree species may inform tree species for phytoremediation of saline soils according to the level of salinity. Optimizing tree species selection also improves the success of wood for energy and revenue generation while restoring degraded soils.To explore the intervention effects of individualized measures on the psychological status of patients with localized small cell lung cancer complicated with pleural effusion (LSCLC-PE). A total of 79 LSCLC patients were selected for comparing the source of psychological control and psychological distress between the patients with combined (group LSCLC-PE, n = 38) and non-combined pleural effusion (group LSCLC, n = 41). LSCLC-PE patients were randomly sub-divided into the control group (CON, for conventional intervention) and the observation group (OBS, for individualized intervention) for evaluating the intervention effects between these two subgroups using the SCL-90 scale. The PHLC score, psychological pain score, and sources of psychological pain (proportion of dyspnea, etc.) in group LSCLC-PE were higher than group LSCLC, but the IHLC and CHLC scores were lower; after intervention, the somatization, obsessive-compulsive symptoms, and total average score in subgroup OBS were statistically lower than subgroup CON. LSCLC-PE patients have poor psychological status, and intervention can improve their psychological status.<br /><br /> Advanced cancer patients are part of a group likely to be more susceptible to COVID-19.<br /><br /> To describe the profile of advanced cancer inpatients to an exclusive Palliative Care Unit (PCU) with the diagnosis of COVID-19, and to evaluate the factors associated with death in these cases.<br /><br /> Retrospective cohort study with data from advanced cancer inpatients to an exclusive PCU, from March to July 2020, with severe acute respiratory syndrome. Diagnostic of COVID-19 and death were the dependent variables. Logistic regression analyses were performed, with the odds ratio (OR) and 95% confidence interval (CI).<br /><br /> One hundred fifty-five patients were selected. The mean age was 60.9 (±13.4) years old and the most prevalent tumor type was breast (30.3%). Eighty-three (53.5%) patients had a diagnostic confirmation of COVID-19. Having diabetes mellitus (OR 2.2; 95% CI 1.1-6.6) and having received chemotherapy in less than 30 days before admission (OR 3.8; 95% CI 1.2-12.2) were associated factors to diagnosis of COVID-19. Among those infected, 81.9% died and, patients with Karnofsky Performance Status (KPS) &lt; 30% (OR 14.8; 95% CI 2.7-21.6) and C-reactive protein (CRP) &gt;21.6mg/L (OR 9.3; 95% CI 1.1-27.8), had a greater chance of achieving this outcome.<br /><br /> Advanced cancer patients who underwent chemotherapy in less than 30 days before admission and who had diabetes mellitus were more likely to develop Coronavirus 2019 disease. Among the confirmed cases, those hospitalized with worse KPS and bigger CRP were more likely to die.<br /><br />Advanced cancer patients who underwent chemotherapy in less than 30 days before admission and who had diabetes mellitus were more likely to develop Coronavirus 2019 disease. Among the confirmed cases, those hospitalized with worse KPS and bigger CRP were more likely to die.<br /><br /> We aimed to analyze deoxycytidine-deoxyguanosine dinucleotide (CpGs) methylation profiles in <br /><br /> , and <br /><br /> promoter regions in osteoarthritis (OA) and Kashin-Beck disease (KBD) patients.<br /><br /> Blood samples were collected from 16 primary OA patients and corresponding 16 healthy individuals and analyzed for methylations in the CpGs of <br /><br /> , and <br /><br /> promoter regions using MALDI-TOF-MS. [https://www.selleckchem.com/products/pbit.html PBIT] The methylation profiles of these regions were then compared between OA and KBD patients.<br /><br /> -1_CpG_2 and <br /><br /> -1_CpG_3 methylations were significantly lower in OA than KBD patients (<br /><br /> &lt; 0.05). A similar trend was observed for <br /><br /> -1_CpG_4, <br /><br /> -1_CpG_7, <br /><br /> -1_CpG_8.9.10, <br /><br /> -1_CpG_13.14.15 and <br /><br /> -1_CpG_16 (<br /><br /> &lt; 0.05) as well as <br /><br /> -1_CpG_1 and <br /><br /> -1_CpG_2 methylation between OA and KBD patients (<br /><br /> &lt; 0.05). However, there was no difference in methylation levels of other CpGs between the 2 groups (<br /><br /> &gt; 0.05).<br /><br /> OA and KBD patients display distinct methylation profiles in the CpG sites of <br /><br /> , and <br /><br /> promoter regions. These findings provide a strong background and new perspective for future studies on mechanisms underlying epigenetic regulation of selenoprotein genes associated with OA and KBD diseases.<br /><br />OA and KBD patients display distinct methylation profiles in the CpG sites of DIO2, GPX3, and TXNRD1 promoter regions. These findings provide a strong background and new perspective for future studies on mechanisms underlying epigenetic regulation of selenoprotein genes associated with OA and KBD diseases.Hypoglycemia is a pathological condition characterized by a low plasma glucose concentration associated with typical autonomic and/or neuroglycopenic symptoms, and resolution of these symptoms with carbohydrate consumption. Hypoglycemia is quite common in clinical practice, particularly in insulin-treated patients with diabetes and in other inherited or acquired conditions involving the regulation of glucose metabolism. Beyond symptoms that might strongly affect the quality of life, hypoglycemia can lead to short- and long-term detrimental consequences for health. Hypoglycemia can be prevented by appropriate changes in dietary habits or by relevant modifications of the drug treatment. Several dietary approaches based on the intake of various carbohydrate foods have been tested for hypoglycemia prevention; among them uncooked cornstarch (UCS) has demonstrated a great efficacy. In this narrative review, we have summarized the current evidence on the UCS usefulness in some conditions characterized by high hypoglycemic risk, focusing on some inherited diseases -i.e. glycogen storage diseases and other rare disorders - and acquired conditions such as type 1 diabetes, postprandial hypoglycemia consequent to esophageal-gastric or bariatric surgery, and insulin autoimmune syndrome. We also considered the possible role of UCS during endurance exercise performance. Lastly, we have discussed the dose requirement, the side effects, the limitations of UCS use, and the plausible mechanisms by which UCS could prevent hypoglycemia.Background An artificial intelligence algorithm that detects age using the 12-lead ECG has been suggested to signal "physiologic age." This study aimed to investigate the association of peripheral microvascular endothelial function (PMEF) as an index of vascular aging, with accelerated physiologic aging gauged by ECG-derived artificial intelligence-estimated age. Methods and Results This study included 531 patients who underwent ECG and a noninvasive PMEF assessment using reactive hyperemia peripheral arterial tonometry. Abnormal PMEF was defined as reactive hyperemia peripheral arterial tonometry index ≤2.0. Accelerated or delayed physiologic aging was calculated by the Δ age (ECG-derived artificial intelligence-estimated age minus chronological age), and the association between Δ age and PMEF as well as its impact on composite major adverse cardiovascular events were investigated. Δ age was higher in patients with abnormal PMEF than in patients with normal PMEF (2.3±7.8 versus 0.5±7.7 years; P=0.01). Reactive hyperemia peripheral arterial tonometry index was negatively associated with Δ age after adjustment for cardiovascular risk factors (standardized β coefficient, -0.08; P=0.048). The highest quartile of Δ age was associated with an increased risk of major adverse cardiovascular events compared with the first quartile of Δ age in patients with abnormal PMEF, even after adjustment for cardiovascular risk factors (hazard ratio, 4.72; 95% CI, 1.24-17.91; P=0.02). Conclusions Vascular aging detected by endothelial function is associated with accelerated physiologic aging, as assessed by the artificial intelligence-ECG Δ age. Patients with endothelial dysfunction and the highest quartile of accelerated physiologic aging have a marked increase in risk for cardiovascular events.<br /><br /> Fibular flaps have been widely used for mandibular and maxillary reconstructions. On occasion, anatomical variants of fibular arteries (FA) will be encountered.<br /><br /> Although anatomical variants of FA during fibular harvest have been reported, controversy exists regarding whether simple color Doppler ultrasonography (CDU) and physical examinations (PE) are sufficient for early preoperative detection.<br /><br /> A 10-year retrospective analysis in our department was performed to find the patients with various FA anomalies confirmed by computed tomography angiography (CTA) or intraoperative findings.<br /><br /> A total number of 19 FA anomalies were found either pre- or intraoperatively in 16 patients, in whom three cases were with bilateral FA variants. Type IIIC variants, also called arteria peronea magna (great peroneal artery), were confirmed in two legs, while the majority (13 legs) had type IIIA hypoplastic/aplastic posterior tibialis arteries (PTA). Four legs had new type IIID (low FA and PTA bifurcations). Preoperative CDU and PE only suspected anomalies in two legs. Six cases proceeded with using the affected fibulas, within whom vascular grafts were used in half of them for lengthening the FA pedicle. Local ischemia, partial soleus muscle necrosis, and claudication were reported in one.<br /><br /> Routine CTA before every fibular harvest, rather than simple PE and CDU, should be added for screening contraindications and ensuring safety for fibular flap harvest.<br /><br />Routine CTA before every fibular harvest, rather than simple PE and CDU, should be added for screening contraindications and ensuring safety for fibular flap harvest.