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Regarding quantitative results, there was no clear evidence that any of the three PRO tools captured positive changes as a result of NAC treatment. CONCLUSION Qualitative results showed a comprehensive characterization of HRQoL in this population based on a symptom/patient-centered approach. These findings will inform future studies. Furthermore, given the similar findings across our multiple methods and endpoints, the introduction of MMR may be a valuable, complementary approach to clinical trials. MMR may be especially useful to incorporate in order to address and follow the FDA's guidance and prioritization on the inclusion of affected individuals' perspectives in clinical trials.Freshwater ecosystems provide irreplaceable services for both nature and society. The quality and quantity of freshwater affect biogeochemical processes and ecological dynamics that determine biodiversity, ecosystem productivity, and human health and welfare at local, regional and global scales. Freshwater ecosystems and their associated riparian habitats are amongst the most biologically diverse on Earth, and have inestimable economic, health, cultural, scientific and educational values. Yet human impacts to lakes, rivers, streams, wetlands and groundwater are dramatically reducing biodiversity and robbing critical natural resources and services from current and future generations. Freshwater biodiversity is declining rapidly on every continent and in every major river basin on Earth, and this degradation is occurring more rapidly than in terrestrial ecosystems. Currently, about one third of all global freshwater discharges pass through human agricultural, industrial or urban infrastructure. About one fifth is generally understood by policy makers, the news media, or the general public, slowing and reversing dramatic losses of freshwater species and ecosystems is still possible. We recommend a set of urgent policy actions that promote clean water, conserve watershed services, and restore freshwater ecosystems and their vital services. Effective management of freshwater resources and ecosystems must be ranked amongst humanity's highest priorities.Human civilization has reached an unprecedented height, but the industrialization of economic development also brings global warming, ozone depletion, acid rain, fresh water resources crisis, energy shortage, and environmental problems. In autumn and winter, haze becomes the usual state in the modern society, and PM2.5 has been becoming an important form of air pollution. The research found that PM2.5 brings great influence to the human body or daily life. To some extent, the PM2.5 also affects the propagation of electromagnetic waves near the ground, reducing the transmission performance of electromagnetic wave. Based on Mie scattering theory, this paper qualitatively analyzed the scattering effects of PM2.5 particles on every frequency band of electromagnetic wave in daily use. [https://www.selleckchem.com/products/d609.html see more] Then the paper takes the satellite navigation signals as a research example, selecting university of Wyoming Davis stations in Antarctica sounding data by measuring the tropospheric atmospheric meteorological parameters (including the atmosphere pressure, geopotential height of different layers, dew point temperature, relative humidity and specific humidity, wind direction, wind speed, and temperature). The paper inversed the refractive index distribution of the troposphere based on AlexNet model and described the error quantitatively. The simulation results show that the estimated error is less than 5.1455%, proving the high accuracy of the AlexNet model. To test the influence of PM2.5, the paper takes Jiuquan, a city with serious pollution, as an example. Comparison between the inversion results and IGS products shows that high concentration of PM2.5 pollution has little influence on the inversion of refractive index profile.Karst regions are important water providers, supplying approximately 25% of the world population. These areas present higher vulnerability to contamination due to hydrodynamics, which hampers the natural depuration of these waters until reaching the underground environment. High concentrations of cadmium (Cd) are observed in the São Miguel watershed, state of Minas Gerais, Brazil. This toxic element is generally and predominantly released into the atmosphere by burning materials that have Cd in their composition, potentially contaminating surface and groundwater. Therefore, the objective of the study is to map Cd concentrations in the hydrological cycle of the São Miguel karst watershed and, through natural background level values (NBL 90%) of rainwater, surface water and groundwater, to understand the seasonal behavior of this element, and to identify the most vulnerable areas to contamination. To achieve this goal, rainwater, surface, and groundwater seasonal monitoring were conducted in 87 sampling stations. A total of 335 samples were collected, distributed over a watershed area of 520&nbsp;km2. Concentrations of cadmium above 1&nbsp;μg/L were found in 21.49% of samples during the rainy season. The origin and distribution of Cd were related to rainfall. For rainwater samples, 90% presented Cd concentration of 3.06&nbsp;μg/L. When these waters precipitate, they contaminate surface waters (NBL 90% = 1.50&nbsp;μg/L) and groundwater (NBL 90% = 2.81&nbsp;μg/L). This study presented a hydrochemical cycle map and proposed NBL values of Cd for surface water and groundwater, helping to understand how the environment is contaminated by this element.Northern China suffers from serious air pollution especially in winter, much of which derives from solid fuel used for domestic heating in rural areas. In order to reduce pollution emissions in the heating season, the Chinese government has introduced a "coal-to-gas conversion" policy, promoting a switch to natural gas which is much cleaner than the coal normally used for winter heating. The "coal-to-gas conversion" project will cover more than 1.8 billion m2 of heated built floor area and affect more than 12 million heat users in Beijing, Tianjin, Hebei, and the surrounding areas. Life cycle assessment and life cycle cost methods are applied to compare and analyze the environmental impact and economic cost of household energy usage for the whole year under 5 scenarios before and after "coal-to-gas conversion." In the three scenarios after "coal-to-gas conversion," the environmental impact decreases by around 50% while the total economic cost increases by around 80%. Particulate emissions responsible for air pollution are considerably reduced with accompanying benefits for human health, though significant, but reduced, impacts on freshwater and marine ecotoxicity remain.