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The CHARISMA intervention, nested within the MTN-025/HOPE vaginal ring trial in Johannesburg, South Africa, seeks to facilitate women's use of HIV prevention products by promoting partner dialogue and mitigating intimate partner violence (IPV). We developed "HEART", a lay counselor-administered relationship assessment tool, for the CHARISMA pilot. The five-scale tool assesses participants' endorsement of Traditional Values (TV), her HIV Prevention Readiness (HPR) and levels of partner support (PS), abuse and control (PAC), and resistance to HIV prevention (PR), guiding decisions about which of three counselling modules to offer (partner communication/A; ring disclosure/B; and IPV prevention/C).<br /><br /> We correlated baseline scores on HEART subscales with a) independent measures of relationship stability, disclosure and IPV to assess construct validity, and b) with specific modules offered to determine how HEART was used in the pilot. We examined changes in HEART scores at three and six months. [https://www.selleckchem.com/products/mevastatin.html selleck chemicals llc] Finally, we ran seed controlled evaluation.<br /><br />These data offer preliminary evidence for HEART construct and predictive validity and support its further evaluation to guide implementation and monitor the impact of the CHARISMA intervention in a randomized controlled evaluation.Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental condition characterized by diminished attentional control. Critically, these difficulties are related to negative consequences in real-life functioning both during development and into adulthood. There is now growing evidence that modulating the underlying neural circuits related to attention can improve behavior and brain function in children with ADHD. We have previously shown that game-based digital therapeutics targeting a key neural marker of attention-midline frontal theta (MFT)-yield positive effects on attentional control in several populations. However, the effects of such digital therapeutics in children with ADHD and no other comorbidities has not been yet examined. link2 To address this gap, we assessed a sample of 25 children with ADHD (8-12 years old) on neural, behavioral, and clinical metrics of attention before and after a 4-week at-home intervention on an iPad targeting MFT circuitry. We found that children showed enhancements on a neural measure of attention (MFT power), as well as on objective behavioral measures of attention and parent reports of clinical ADHD symptoms. Importantly, we observed relationships between the neural and behavioral cognitive improvements, demonstrating that those children who showed the largest intervention-related neural gains were also those that improved the most on the behavioral tasks indexing attention. These findings provide support for using targeted, digital therapeutics to enhance multiple features of attentional control in children with ADHD. Study registration ClinicalTrials.gov registry (NCT03844269) https//clinicaltrials.gov/ct2/show/NCT03844269.To facilitate longer duration space travel, flight crew sickness and disease transmission amongst the crew must be eliminated. High contact surfaces within space vehicles provide an opportunity for bacterial adhesion, which can lead to biofilm formation or disease transmission. This study evaluates the performance of several nonfouling polymers using citizen science, to identify the best performing chemistry for future applications as bacteria resistant coatings. The specific polymer chemistries tested were zwitterionic sulfobetaine methacrylate (SBMA), and polyampholytes composed of [2-(acryloyloxy)ethyl] trimethylammonium chloride and 2-carboxyethyl acrylate (TMA/CAA), or TMA and 3-sulfopropyl methacrylate (TMA/SA). Each polymer chemistry is known to exhibit bacteria resistance, and this study provides a direct side-by-side comparison between the chemistries using a citizen science approach. Nearly 100 citizen scientists returned results comparing the performance of these polymers over repeat exposure to bacteria and 30 total days of growth. The results demonstrate that TMA/CAA polyampholyte hydrogels show the best long-term resistance to bacteria adhesion.Soil loss caused by erosion is a global problem. Therefore, the assessment of soil erosion and the its driving mechanism are of great significance to soil conservation. However, soil erosion is affected by both climate change and human activities, which have not been quantified, and few researchers studied the differences in the driving mechanisms of soil erosion depending on the land use type. Therefore, the spatiotemporal characteristics and changing trends of soil erosion in the Dongting Lake Basin were analyzed in this study. Geographic detectors were used to identify the dominant factors affecting soil erosion in different land use types. In this study, a sensitivity experiment was conducted to clarify the relative contributions of climate change and human activities to soil erosion changes. In addition, we studied the effects of different land use types and vegetation cover restoration on soil erosion. The results show that soil erosion in the Dongting Lake Basin decreased from 2000 to 2018. Human activities represented by land use types and vegetation coverage significantly contributed to the alleviation of soil erosion in the Dongting Lake Basin, whereas climate change represented by rainfall slightly aggravated soil erosion in the study area. The restoration of grassland vegetation and transfer of cultivated land to woodlands in the study area improved the soil erosion. The slope steepness is the key factor affecting the intensity of soil erosion in dry land, paddy fields, and unused land, whereas the vegetation coverage is the key factor affecting the intensity of soil erosion in woodland, garden land, and grassland. Detailed spatiotemporally mapping of soil erosion was used to determine the connections between soil erosion and potential drivers, which have important implications for vegetation restoration and the optimization of land use planning.Populist attitudes are generally measured in surveys through three necessary and non-compensatory elements of populism, namely anti-elitism, people-centrism, and Manicheanism. Using Comparative Study of Electoral Systems Module 5 (2016-2020) data for 30 countries, we evaluate whether this approach explains voting for populist parties across countries in Asia, Europe and the Americas. We show that the existing scales of populist attitudes effectively explain voting for populists in countries where populist leaders and parties are in opposition but fail to explain voting for populist parties in countries where they are in power. We argue that current approaches assume "the elite" to mean "politicians", thus failing to capture attitudes towards "non-political elites" often targeted by populists in office-in particular, journalists, academics/experts, bureaucrats, and corporate business leaders. The results reveal limits to the usefulness of existing survey batteries in cross-national studies of populism and emphasize the need to develop approaches that are more generalizable across political and national contexts.<br /><br /> The prevalence of diabetes and the use of electronic health (eHealth) are increasing. Lifestyle changes in a positive direction may reduce morbidity and mortality in patients with diabetes. The main objective of this study was to test the association between lifestyle changes based on online information seeking and discussing the information with a doctor.<br /><br /> In this cross-sectional study we used e-mail survey data from 1250 members of The Norwegian Diabetes Association, collected in 2018. Included in the analyses were 847 men and women aged 18 to 89 years diagnosed with diabetes and who reported use of eHealth within the previous year. We used descriptive statistics to estimate lifestyle changes based on information from the internet. Logistic regressions were used to estimate the associations between lifestyle changes after online information seeking and discussing the information with a doctor. Analyses were adjusted for gender, age, education, and self-rated health.<br /><br /> Lifestyle changes accomplished afterasily accessible high-quality online information, as well as the importance of making room for discussing lifestyle in the clinical encounter.The largest migraine genome-wide association study identified 38 candidate loci. In this study we assessed whether these results replicate on a gene level in our European cohort and whether effects are altered by lifetime depression. We tested SNPs of the loci and their vicinity with or without interaction with depression in regression models. Advanced analysis methods such as Bayesian relevance analysis and a neural network based classifier were used to confirm findings. Main effects were found for rs2455107 of PRDM16 (OR = 1.304, p = 0.007) and five intergenic polymorphisms in 1p31.1 region two of them showed risk effect (OR = 1.277, p = 0.003 for both rs11209657 and rs6686879), while the other three variants were protective factors (OR = 0.4956, p = 0.006 for both rs12090642 and rs72948266; OR = 0.4756, p = 0.005 for rs77864828). Additionally, 26 polymorphisms within ADGRL2, 2 in REST, 1 in HPSE2 and 33 mostly intergenic SNPs from 1p31.1 showed interaction effects. Among clumped results representing these significant regions, only rs11163394 of ADGRL2 showed a protective effect (OR = 0.607, p = 0.002), all other variants were risk factors (rs1043215 of REST with the strongest effect OR = 6.596, p = 0.003). Bayesian relevance analysis confirmed the relevance of intergenic rs6660757 and rs12128399 (p31.1), rs1043215 (REST), rs1889974 (HPSE2) and rs11163394 (ADGRL2) from depression interaction results, and the moderate relevance of rs77864828 and rs2455107 of PRDM16 from main effect analysis. Both main and interaction effect SNPs could enhance predictive power with the neural network based classifier. In summary, we replicated p31.1, PRDM16, REST, HPSE2 and ADGRL2 genes with classic genetic and advanced analysis methods. While the p31.1 region and PRDM16 are worthy of further investigations in migraine in general, REST, HPSE2 and ADGRL2 may be prime candidates behind migraine pathophysiology in patients with comorbid depression.<br /><br /> To explore and compare urine proteome changes among rat models by intraperitoneal injection with single bacteria and co-injection with two bacteria.<br /><br /> Escherichia coli and Staphylococcus aureus are two common human pathogens. link3 Three rat models were established (i) the intraperitoneal co-injection of E. coli and S. aureus model (ES model), (ii) intraperitoneal injection of E. coli model (E model), and (iii) intraperitoneal injection of S. aureus model (S model). Urinary proteomes on days 0, 1 and 2 of the three models were analyzed by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).<br /><br /> A total of 111, 34 and 94 differential proteins were identified in the ES model, E model and S model, respectively. Among them, some differential proteins were reported to be associated with bacterial infection. Approximately 47% differential proteins in the E model overlapped with ES model, and 37% differential proteins in the S model overlapped with ES model. Compared with the E model and S model, a total of 71 unique differential proteins were identified in the ES model.