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Bacterial resistance toward antibiotics is a world-wide problem, and one potential solution to fight against the resistance is to develop multi-mechanism antimicrobial agents to achieve synergistic performance. Titanium carbide (MXene) is an emerging 2D nanomaterial with antimicrobial ability to physically damage bacterial membrane and chemically induce oxidative stress, and it can be further conjugated with nanomaterials to improve its antibacterial performance. Herein, a synergistic antimicrobial agent is developed through conjugation of the ultra-small gold nanoclusters (AuNCs) on MXene nanosheets. The conjugated AuNCs are effectively delivered into bacteria after bacterial membrane damage caused by MXene, generating localized reactive oxygen species (ROS) of high concentration to effectively oxidize bacterial membrane lipid for enhanced membrane broken, as well as bacterial DNA for violent fragmentation. Thus, the synergistic physical (via MXene) and chemical (via MXene and AuNCs) antimicrobial mechanisms lead to eventual bacterial death of both Gram-positive and Gram-negative bacteria, with low IC50 values of 11.7 µg mL-1 of MXene and 0.04 µm of AuNCs. Moreover, the crumpled MXene-AuNCs structure is constructed to inhibit biofilm formation, which hold synergistic antibacterial ability of MXene-AuNCs conjugation, hydrophobic surface to prevent bacterial attachment, and large surface area containing higher density of bactericides.<br /><br /> The impact of pediatric hematopoietic stem cell transplant (HCT) on family functioning varies, but little is known about how the timing of HCT in children's treatment course contributes to this variability. This study examines how preexisting child, sibling, and family problems, the length of time between diagnosis to HCT, and children's age at HCT are associated with family and caregiver functioning.<br /><br /> Caregivers (n=140) of children (≤18 years old) scheduled to undergo their first HCT completed the Psychological Assessment Tool-HCT and the Impact on Family Scale. Treatment information was extracted from electronic medical records. A bootstrapped multivariate path analysis was used to test the hypotheses.<br /><br /> More preexisting family problems related to greater caregiver perceived negative impact of their child's HCT across family and caregiver functioning domains. Less time between diagnosis and HCT was associated with greater caregiver personal strain, particularly for those with younger children undergoing ung children or who are abruptly learning of their child's need for an HCT, may assist providers in identifying families who would benefit from earlier or more intensive psychosocial support.The activity of influenza A at the end of 2019 was higher than previous two years in children younger than 6 years old in Wuhan, China. The 2019-2020 winter peak of seasonal influenza preceded the COVID-19 outbreak, with a higher and earlier peak than those of the 2017-2018 and 2018-2019 seasons. We speculate this could be due to the earlier CNY holiday season in 2019-2020 than in previous two years. [https://www.selleckchem.com/products/lys05.html this website] We compared these results with those of two previous studies to further discuss the possible interference between influenza and COVID-19 in young children.<br /><br /> Although exposure to stress is common among children and their parents, longitudinal research on the effects of perceived stress on child obesity risk is lacking. This study examined the 3-year longitudinal associations of children and mothers' perceived stress with children's body mass index (BMI).<br /><br /> A sample of 199 mothers and their children (8-12 years at baseline, 56% Hispanic) completed six semi-annual assessments across 3 years with questionnaire-based self-report measures of perceived stress and measured height/weight. Parallel process latent growth curve modelling specified regressions of latent intercept and slope of children's BMI on latent intercepts and slopes for mothers' and children's perceived stress.<br /><br /> Greater child self-reported perceived stress at baseline predicted greater increase in children's BMI across the six assessments whereas mother self-reported perceived stress at baseline was unrelated to change in child BMI. Baseline child BMI was unrelated to change in children or mothers' perceived stress across the six assessment waves.<br /><br /> Children's own perceptions of stress may play a larger contributing role in BMI progression during middle childhood than their mother's perceived stress levels. These findings underscore the importance of focusing on children's stress-coping strategies for promoting a healthy weight.<br /><br />Children's own perceptions of stress may play a larger contributing role in BMI progression during middle childhood than their mother's perceived stress levels. These findings underscore the importance of focusing on children's stress-coping strategies for promoting a healthy weight.As the world moves toward electromobility, our daily lives are flooded with variety of lithium ion batteries (LIBs), and the concerns of cost, safety and environmental friendliness of LIBs spring up in the minds of scientists. Although organic electrodes have been considered as promising alternatives to their inorganic counterparts, some intrinsic weaknesses still plague scientists, such as high solubility, low conductivity and sluggish ion diffusion. The emergence of covalent organic frameworks (COFs) attracts our attention because of their robust networks and open pores that could facilitate the infiltration of electrolyte ions when used as electrodes for metal-ion batteries (MIBs). In this review, we summarized the recent progress of COFs as electrode materials, and the strategies toward enhancing electrochemical performance of COF-based electrode in MIBs are discussed. Hopefully, this review will provide a fundamental guidance for future development of COF-based electrodes.Warning signals are predicted to develop signal monomorphism via positive frequency-dependent selection (+FDS) albeit many aposematic systems exhibit signal polymorphism. To understand this mismatch, we conducted a large-scale predation experiment in four countries, among which the frequencies of hindwing warning coloration of the aposematic moth, Arctia plantaginis, differ. Here we show that selection by avian predators on warning colour is predicted by local morph frequency and predator community composition. We found +FDS to be the strongest in monomorphic Scotland and lowest in polymorphic Finland, where the attack risk of moth morphs depended on the local avian community. +FDS was also found where the predator community was the least diverse (Georgia), whereas in the most diverse avian community (Estonia), hardly any models were attacked. Our results support the idea that spatial variation in predator communities alters the strength or direction of selection on warning signals, thus facilitating a geographic mosaic of selection.