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Finally, we show that MPN-BP ICs originate from not only phenotypically identified hematopoietic stem cells, but also lymphoid-myeloid progenitor cells, which were each characterized by differences in MPN-BP initiating activity and self-renewal capacity.Replication of SARS-CoV-2 in the human population is defined by distributions of mutants that are present at different frequencies within the infected host and can be detected by ultra-deep sequencing techniques. In this study, we examined the SARS-CoV-2 mutant spectra of amplicons from the spike-coding (S-coding) region of 5 nasopharyngeal isolates derived from patients with vaccine breakthrough. Interestingly, all patients became infected with the Alpha variant, but amino acid substitutions that correspond to the Delta Plus, Iota, and Omicron variants were present in the mutant spectra of the resident virus. Deep sequencing analysis of SARS-CoV-2 from patients with vaccine breakthrough revealed a rich reservoir of mutant types and may also identify tolerated substitutions that can be represented in epidemiologically dominant variants.This article concerns with the asynchronous boundary control for a class of Markov jump reaction-diffusion neural networks (MJRDNNs). In consideration of nonsynchronous behavior between the system modes and controller modes, a novel asynchronous boundary control design is proposed for MJRDNNs. Based on the designed asynchronous boundary controller, a sufficient criterion is established to ensure the stochastic finite-time boundedness for the considered MJRDNNs by constructing a Lyapunov-Krasovskii functional and utilizing Wirtinger-type inequality. Then, a sufficient condition is acquired to guarantee that MJRDNNs are stochastic finite-time bounded with performance. Finally, a numerical example is provided to illustrate the effectiveness of the proposed design method.In this article, we focus on the state estimation problems for a system with protecting user privacy. Regarding whether the user has conducted a sensitive action in the system as a kind of privacy, we propose a privacy-preserving mechanism (PPM) to prevent its action results from being disclosed or inferred. For such a system with the PPM, we first obtain the optimal estimator (OE). Subject to the inoperability of the OE in practice, we turn to designing a computationally efficient suboptimal estimator (SE) as an alternative. Then, we prove that this SE can remain stable while satisfying the user's requirements on both privacy protection and estimation performance. By solving a privacy-preserving optimization problem, a set of guidelines is established to customize a tradeoff between privacy and performance according to the user's demand. Finally, illustrated examples are used to illustrate the main theoretical results.Edge intelligent computing is widely used in the fields, such as the Internet of Medical Things (IoMT) and industrial control UAV clusters, which has advantages, including high data processing efficiency, strong real-time performance and low network delay. However, there are many problems including privacy disclosure, limited calculation force when edge intelligent devices, edge gateways and clouds complete the task unloading, as well as scheduling and coordination issues. Federated learning allows all training devices to complete training at the same time, which greatly improves training efficiency. However, traditional federated learning will expose patient's privacy information of the training set. Due to the sensitive nature of the healthcare data, the aforementioned approach of transferring the patient's data to the central servers may create serious security and privacy issues. Therefore, this article proposes a Privacy Protection Scheme for Federated Learning under Edge Computing (PPFLEC). First of alle.Accurate and robust cephalometric image analysis plays an essential role in orthodontic diagnosis, treatment assessment and surgical planning. This paper proposes a novel landmark localization method for cephalometric analysis using multiscale image patch-based graph convolutional networks. In detail, image patches with the same size are hierarchically sampled from the Gaussian pyramid to well preserve multiscale context information. We combine local appearance and shape information into spatialized features with an attention module to enrich node representations in graph. The spatial relationships of landmarks are built with the incorporation of three-layer graph convolutional networks, and multiple landmarks are simultaneously updated and moved toward the targets in a cascaded coarse-to-fine process. Quantitative results obtained on publicly available cephalometric X-ray images have exhibited superior performance compared with other state-of-the-art methods in terms of mean radial error and successful detection rate within various precision ranges. Our approach performs significantly better especially in the clinically accepted range of 2 mm and this makes it suitable in cephalometric analysis and orthognathic surgery.With the rapid development of machine learning in the medical cloud system, cloud-assisted medical computing provides a concrete platform for remote rapid medical diagnosis services. Support vector machine (SVM), as one of the important algorithms of machine learning, has been widely used in the field of medical diagnosis for its high classification accuracy and efficiency. In some existing schemes, healthcare providers train diagnostic models with SVM algorithms and provide online diagnostic services to doctors. Doctors send the patient's case report to the diagnostic models to obtain the results and assist in clinical diagnosis. However, case report involves patients' privacy, and patients do not want their sensitive information to be leaked. Therefore, the protection of patient's privacy has become an important research direction in the field of online medical diagnosis. In this paper, we propose a privacy-preserving medical diagnosis scheme based on multi-class SVMs. [https://www.selleckchem.com/products/azd0095.html MCT inhibitor] The scheme is based on the distributed two trapdoors public key cryptosystem (DT-PKC) and Boneh-Goh-Nissim (BGN) cryptosystem. We design a secure computing protocol to compute the core process of the SVM classification algorithm. Our scheme can deal with both linearly separable data and nonlinear data while protecting the privacy of user data and support vectors. The results show that our scheme is secure, reliable, scalable with high accuracy.Parkinson's disease (PD) is a neurodegenerative disease that affects motor abilities with increasing severity as the disease progresses. Traditional methods for diagnosing PD include a section where a trained specialist scores qualitative symptoms using the motor subscale of the Unified Parkinson's Disease Rating Scale (UPDRS-III). The aim of this feasibility study was twofold. First, to evaluate quiet standing as an additional, out-of-clinic, objective feature to predict UPDRS-III subscores related to motor symptom severity; and second, to use quiet standing to detect the presence of motor symptoms. Force plate data were collected from 42 PD patients and 43 healthy controls during quiet standing (a task involving standing still with eyes open and closed) as a feasible task in clinics. Predicting each subscore of the UPDRS-III could aid in identifying progression of PD and provide specialists additional tools to make an informed diagnosis. Random Forest feature importance indicated that features correlated with range of center of pressure (i.e., the medial-lateral and anterior-posterior sway) were most useful in the prediction of the top PD prediction subscores of postural stability (r = 0.599; p = 0.014), hand tremor of the left hand (r = 0.650; p = 0.015), and tremor at rest of the left upper extremity (r = 0.703; p = 0.016). Quiet standing can detect body bradykinesia (AUC-ROC = 0.924) and postural stability (AUC-ROC = 0.967) with high predictability. Although there are limited data, these results should be used as a feasibility study that evaluates the predictability of individual UPDRS-III subscores using quiet standing data.Sleep staging is an important step in analyzing sleep quality. Traditional manual analysis by psychologists is time-consuming. In this paper, we propose an automatic sleep staging model with an improved attention module and hidden Markov model (HMM). The model is driven by single-channel electroencephalogram (EEG) data. It automatically extracts features through two convolution kernels with different scales. Subsequently, an improved attention module based on Squeeze-and-Excitation Networks (SENet) will perform feature fusion. The neural network will give a preliminary sleep stage based on the learned features. Finally, an HMM will apply sleep transition rules to refine the classification. The proposed method is tested on the sleep-EDFx dataset and achieves excellent performance. The accuracy on the Fpz-Cz channel is 84.6%, and the kappa coefficient is 0.79. For the Pz-Oz channel, the accuracy is 82.3% and kappa is 0.76. The experimental results show that the attention mechanism plays a positive role in feature fusion. And our improved attention module improves the classification performance. In addition, applying sleep transition rules through HMM helps to improve performance, especially N1, which is difficult to identify.Nowadays, vision-based computing tasks play an important role in various real-world applications. However, many vision computing tasks, e.g., semantic segmentation, are usually computationally expensive, posing a challenge to the computing systems that are resource-constrained but require fast response speed. Therefore, it is valuable to develop accurate and real-time vision processing models that only require limited computational resources. To this end, we propose the spatial-detail guided context propagation network (SGCPNet) for achieving real-time semantic segmentation. In SGCPNet, we propose the strategy of spatial-detail guided context propagation. It uses the spatial details of shallow layers to guide the propagation of the low-resolution global contexts, in which the lost spatial information can be effectively reconstructed. In this way, the need for maintaining high-resolution features along the network is freed, therefore largely improving the model efficiency. On the other hand, due to the effective reconstruction of spatial details, the segmentation accuracy can be still preserved. In the experiments, we validate the effectiveness and efficiency of the proposed SGCPNet model. On the Cityscapes dataset, for example, our SGCPNet achieves 69.5% mIoU segmentation accuracy, while its speed reaches 178.5 FPS on 768 x 1536 images on a GeForce GTX 1080 Ti GPU card. In addition, SGCPNet is very lightweight and only contains 0.61 M parameters. The code will be released at https//github.com/zhouyuan888888/SGCPNet.Identifying the geolocation of social media users is an important problem in a wide range of applications, spanning from disease outbreaks, emergency detection, local event recommendation, to fake news localization, online marketing planning, and even crime control and prevention. Researchers have attempted to propose various models by combining different sources of information, including text, social relation, and contextual data, which indeed has achieved promising results. However, existing approaches still suffer from certain constraints, such as 1) a very few samples are available and 2) prediction models are not easy to be generalized for users from new regions--which are challenges that motivate our study. In this article, we propose a general framework for identifying user geolocation--MetaGeo, which is a meta-learning-based approach, learning the prior distribution of the geolocation task in order to quickly adapt the prediction toward users from new locations. Different from typical meta-learning settings that only learn a new concept from few-shot samples, MetaGeo improves the geolocation prediction with conventional settings by ensembling numerous mini-tasks.