Zobrazení zdroje stránky Mosegaardmcclure5655

An ideal solar-thermal absorber requires efficient selective absorption with a tunable bandwidth, excellent thermal conductivity and stability, and a simple structure for effective solar thermal energy conversion. Despite various solar absorbers having been demonstrated, these conditions are challenging to achieve simultaneously using conventional materials and structures. Here, we propose and demonstrate three-dimensional structured graphene metamaterial (SGM) that takes advantages of wavelength selectivity from metallic trench-like structures and broadband dispersionless nature and excellent thermal conductivity from the ultrathin graphene metamaterial film. The SGM absorbers exhibit superior solar selective and omnidirectional absorption, flexible tunability of wavelength selective absorption, excellent photothermal performance, and high thermal stability. Impressive solar-to-thermal conversion efficiency of 90.1% and solar-to-vapor efficiency of 96.2% have been achieved. These superior properties of the&nbsp;SGM absorber suggest it has a great potential for practical applications of solar thermal energy harvesting and manipulation.BACKGROUND Oxidative stress and myocardial apoptosis are features of doxorubicin-induced cardiac toxicity that can result in cardiac dysfunction. Previous studies showed that microRNA-143 (miR-143) was expressed in the myocardium and had a role in cardiac function. This study aimed to investigate the effects and possible molecular mechanisms of miR-143 on oxidative stress and myocardial cell apoptosis in a mouse model of doxorubicin-induced cardiac toxicity. MATERIAL AND METHODS Mice underwent intraperitoneal injection of doxorubicin (15 mg/kg) daily for eight days to develop the mouse model of doxorubicin-induced cardiac toxicity. Four days before doxorubicin administration, a group of mice was pretreated daily with a miR-143 antagonist (25 mg/kg/day) for four consecutive days by tail vein injection. The study included the use of a miR-143 antagomir, or anti-microRNA, an oligonucleotide that silenced endogenous microRNA (miR), and an agomir to miR-143, and also the AKT inhibitor, MK2206. Quantitative real-time polymerase chain reaction (qRT-PCR) and immunoblot analysis were used to measure mRNA and protein expression, respectively. RESULTS Doxorubicin treatment increased the expression of miR-143, which was reduced by the miR-143 antagomir. Overexpression of miR-143 increased doxorubicin-induced myocardial apoptosis and oxidative stress. The use of the miR-143 antagomir significantly activated protein kinase B (PKB) and AKT, which were reduced in the presence of the AKT inhibitor, MK2206. However, the use of the miR-143 antagomir further down-regulated AKT phosphorylation following doxorubicin treatment and increased AKT activation. CONCLUSIONS In a mouse model of doxorubicin-induced cardiac toxicity, miR-143 increased oxidative stress and myocardial cell apoptosis following doxorubicin treatment by inhibiting AKT.BACKGROUND CNS involvement in Hodgkin lymphoma is rare. Despite various treatment options, median overall survival is only 13 months after diagnosis of CNS involvement in relapsed/refractory HL. CASE REPORT A 29-year-old woman with classical HL (mixed cellularity) in clinical stage IIB was treated with multilineage chemotherapy and radiotherapy without achieving a sustained complete remission. Systemic and CNS progression of HL occurred at the age of 32 years and the patient received 2 cycles of brentuximab vedotin with bendamustine alternating with 2 cycles of high-dose methotrexate-based treatment and achieved partial remission. She then underwent autologous stem cell transplantation followed by brentuximab vedotin consolidation. The disease progressed and the patient died 6 months after the last dose of brentuximab vedotin. CONCLUSIONS We demonstrated a durable response to brentuximab vedotin-based chemotherapy in a patient with refractory Hodgkin lymphoma with CNS involvement. Prognosis of these patients is poor and new treatment options are needed.in English, Italian Il melanoma maligno può avere una localizzazione primitiva intestinale oppure essere la manifestazione secondaria di un melanoma extra intestinale. L’occlusione intestinale per intussuscezione da metastasi di melanoma è un evento molto raro e rappresenta in letteratura meno del 5% dei casi. [https://www.selleckchem.com/products/LBH-589.html https://www.selleckchem.com/products/LBH-589.html] I pazienti possono rimanere asintomatici e le metastasi possono manifestarsi anche 10 anni dopo la lesione primitiva. Infatti, meno del 5% delle metastasi di melanoma del tratto gastrointestinale vengono diagnosticate in vivo, solo a seguito dell’insorgenza di una complicanza come l’occlusione intestinale. In particolar modo il paziente si presenta con una sintomatologia del tutto aspecifica e pertanto la diagnosi viene posta a seguito dell’intervento chirurgico. Viene presentato il caso di una paziente donna di 58 anni con storia clinica di pregressa asportazione di un melanoma cutaneo 5 anni prima. La paziente viene ricoverata con diagnosi di addome acuto e sottoposta ad intervento chirurgico laparoscopico. Il quadro clinico di occlusione intestinale causata da intussuscezione secondaria a metastasi di melanoma cutaneo è una condizione molto rara e la chirurgia resettiva radicale è il trattamento curativo che consente la maggior sopravvivenza del paziente.in English, Italian SCOPO DELLO STUDIO La fibromatosi mesenterica primiva è un raro tipo di fibromatosi intra-addominale localmente invasiva, con un tasso di recidiva molto elevato. In questo studio, abbiamo mirato a presentare il nostro approccio chirurgico, le caratteristiche del tumore, la presentazione clinica e i risultati di follow-up a lungo termine nei casi di fibromatosi mesenterica primaria. MATERIALE E METODI I dati raccolti da 11 pazienti sottoposti a intervento chirurgico a causa della fibromatosi mesenterica primaria nella nostra clinica tra il 2010 e il 2019 sono stati analizzati retrospettivamente. RISULTATI Il nostro studio è fondato su 11 pazienti sei donne e 5 uomini, di età media di 44,2±15,8 anni. La massa addominale è stata rilevata in 5 pazienti (45,5%) che avevano lamentato ostruzione meccanica dell’intestino con nausea e vomito, dolore addominale, distensione addominale. Due pazienti (18,2%) sono stati operati con una diagnosi di addome acuto in situazioni di emergenza per ostruzione meccanica dell’intestino in uno di essi, e per perforazione gastrointestinale in un altro paziente.