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Telemedicine had been proposed as a tool to manage diabetes, but its role in management of diabetic foot ulcer is still evolving. The COVID-19 pandemic and related social restrictions have necessitated the use of telemedicine in the management of diabetic foot disease (tele-podiatry), particularly of patients classified as low-risk.<br /><br /> We present a report of three cases of varied diabetic foot problems assessed during the present pandemic using different forms of telemedicine for triaging, management of low-risk cases and for follow-up.<br /><br /> Tele-podiatry was effective in the management of low-risk subjects with diabetic foot ulcer, and also useful in referral of high-risk subjects for hospital/clinic visit, facilitating proper management. It also helped in the follow-up of the cases.<br /><br /> Telemedicine is a good screening tool for diagnosing and managing low-risk subjects with diabetic foot problems, and also enables a triaging system for deciding on hospital visits and hospitalization. Telemedicine offers several benefits in the management of diabetic foot disease, although it also has some limitations. Based on our experience during the pandemic, we recommend its judicious use in the triaging of patients of diabetic foot disease and management of low-risk cases. Future innovation in technology and artificial intelligence may help in better tele-podiatry care in the time to come.<br /><br />Telemedicine is a good screening tool for diagnosing and managing low-risk subjects with diabetic foot problems, and also enables a triaging system for deciding on hospital visits and hospitalization. Telemedicine offers several benefits in the management of diabetic foot disease, although it also has some limitations. Based on our experience during the pandemic, we recommend its judicious use in the triaging of patients of diabetic foot disease and management of low-risk cases. Future innovation in technology and artificial intelligence may help in better tele-podiatry care in the time to come.<br /><br /> Given the limited information describing the connection between metabolic syndrome (MetS) and Coronavirus Disease 2019 (COVID-19), we aimed to assess the impact of MetS on morbidity and mortality among COVID-19 patients.<br /><br /> This retrospective cohort study was performed from 1st April to May 3, 2020 on 157 ICU-admitted COVID-19 patients in Shahid Modarres Hospital in Tehran, Iran. Patients' clinical, laboratory and radiological findings, and subsequent complications, were collected and compared between MetS and non-MetS groups.<br /><br /> 74 of all cases had MetS. Among the MetS components, waist circumference (p-value=0.006 for men; p-value&lt;0.0001 for women), Triglycerides (p-value=0.002), and Fasting Blood Sugar (p-value=0.007) were significantly higher in MetS group; with no statistical difference found in HDL levels (p-value=0.21 for men; p-value=0.13 for women), systolic blood pressure(p-value=0.07), and diastolic blood pressure (p-value=0.18) between two groups. Length of ICU admission (p-value=0.009), the ne among COVID-19 ICU-admitted patients.Metal hybrid additive manufacturing (AM) processes are suitable to create complex structures that advance engineering performance. Hybrid AM can be used to create functionally graded materials for which the variation in microstructure and material properties across the domain is created through a synergized combination of fully-coupled manufacturing processes and/or energy sources. This expansion in the engineering design and manufacturing spaces presents challenges for nondestructive evaluation, including the assessment of the sensitivity of nondestructive measurements to functional gradients. To address this problem, linear ultrasound measurements are used to interrogate 420 stainless steel coupons from three manufacturing methods wrought, AM, and hybrid AM (directed energy deposition + laser peening). Wave speed, attenuation, and diffuse backscatter results are compared with microhardness measurements along the build/axial direction of the coupons, while microstructure images are used for qualitative verification. The ultrasound measurements compare well with the destructive measurements without any substantial loss in resolution. Furthermore, ultrasonic methods are shown to be effective for identification of the gradient and cyclic nature of the elastic properties and microstructure on the hybrid AM coupon. These results highlight the potential of ultrasound as an efficient and accessible nondestructive characterization method for hybrid AM samples and inform further nondestructive evaluation decisions in AM.Oil spill accidents are a major concern for aquatic organisms. In recent history, the Deepwater Horizon blowout spilled 500 million liters of crude oil into the Gulf of Mexico. Corexit 9500A was used to disperse the oil since it was the method approved at that time, despite safety concerns about its use. A better solution is necessary for dispersing oil from spills that reduces the toxicity to exposed aquatic organisms. To address this challenge, novel engineered nanoparticles were designed using silica cores grafted with hyperbranched poly(glycidol) branches. Because the silica core and polymers are known to be biocompatible, we hypothesized that these particles are nontoxic to fathead minnows (Pimephales promelas) and would decrease their exposure to oil polyaromatic hydrocarbons. [https://www.selleckchem.com/products/direct-red-80.html see more] Fathead minnow embryos, juveniles and adult stages were exposed to the particles alone or in combination with a water-accommodated fraction of oil. Acute toxicity of nanoparticles to fish was tested by measuring mortality. Sub-letatic hydrocarbons confirmed their presence in the tested solutions and the reduction of available PAH in WAF treated with the nanoparticles. Our findings suggest the engineered nanoparticles may be protecting the fish by sequestering polyaromatic hydrocarbons from oil, measured indirectly by the induction of cypa1 mRNAs. Furthermore, chemical analysis showed a reduction in PAH content in the water accommodated fraction with the presence of nanoparticles.There is an urgent need for developing advanced purification techniques with the merits of low cost and satisfactory capacity in order to meet the challenges in the current downstream purification of monoclonal antibodies (mAbs). Herein, a simple and inexpensive nitrogen heterocycle molecule, 1-vinylimidazole (VIM), was proposed as the capture ligand of antibodies for the first time. The corresponding VIM-based non-affinity polymeric material (polyVIM) was then fabricated via a one-step polymerization for use in the highly selective purification of antibodies. Compared to the previously reported materials, this novel material exhibited many advantages without clearly sacrificing selectivity, such as a simpler and faster fabrication (within 1.5 h), comparable or even higher binding capacity (saturated static adsorption capacity &gt; 190 mg/g polymer, dynamic binding capacity about 31.62 mg/g polymer), lower non-specific protein adsorption, and much lower cost. Notably, the polyVIM can effectively purify the antibodies from multiple biological sources with high purity (95.