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Two independent reviewers determined the eligibility of the studies and will independently extract the data. Risk of bias will be assessed using the COSMIN risk-of-bias checklist, and the quality of the results will be assessed using specific COSMIN quality criteria.<br /><br /> It is not necessary to obtain ethical approval for this systematic review protocol. The results will be published in a peer-reviewed journal and presented at a relevant conference.<br /><br /> CRD42020149120.<br /><br />CRD42020149120.<br /><br /> Prophylactic drugs currently used for migraine treatment are not specific. Furthermore, few studies in existing literature describe drugs utilisation patterns and adherence to migraine prophylactic treatment. This study is aimed to describe utilisation patterns of migraine drugs, evaluate adherence to prophylactic medications and investigate drug-related costs.<br /><br /> Retrospective population-based study using an administrative health-related database.<br /><br /> Primary care setting in the Campania region, Southern Italy.<br /><br /> This study was carried out between 1 January 2016 and 31 December 2018, involving 12 894 subjects with any primary or secondary hospital discharge with migraine diagnosis, or at least two medical dispensations of migraine-specific acute or prophylactic medications (triptans or pizotifen). Subjects were classified into four treatment cohorts no treatment, acute, prophylactic and both acute and prophylactic. Subjects were followed-up for 1 year.<br /><br /> Utilisation patterns of migraine drugs at treatment ini unmet need for improved prophylactic therapies in order to provide a better disease management.<br /><br />Migraine treatment with acute medications is still prevalent in Italy; only few patients received prophylactic treatment with poor adherence to treatment. These findings reflect an unmet need for improved prophylactic therapies in order to provide a better disease management.<br /><br /> To evaluate the usability and acceptability of an electronic consent pilot intervention for school-based immunisations and assess its impact on consent form returns and human papilloma virus (HPV) vaccine uptake.<br /><br /> Mixed-methods theory-informed study applying qualitative methods to examine the usability and acceptability of the intervention and quantitative methods to assess its impact.<br /><br /> The intervention was piloted in 14 secondary schools in seven London boroughs in 2018. Intervention schools were matched with schools using paper consent based on the proportion of students with English as a second language and students receiving free school meals. Participants included nurses, data managers, school-link staff, parents and adolescents.<br /><br /> An electronic consent portal where parents could record whether they agreed to or declined vaccination, and nurses could access data to help them manage the immunisation programme.<br /><br /> Comparison of consent form return rates and HPV vaccine uptake between intervention and mad its impact.<br /><br />The pilot intervention did not improve consent form return or vaccine uptake due to challenges encountered in transitioning to new working practice. [https://www.selleckchem.com/products/mrtx849.html MRTX849 price] New technologies require embedding before they become incorporated in everyday practice. A re-evaluation once stakeholders are accustomed with electronic consent may be required to understand its impact.<br /><br /> To assess differences in weight status and movement behaviour guideline compliance among children aged 5-12 years with and without a family history of non-communicable diseases (NCDs).<br /><br /> Prospective.<br /><br /> Women born between 1973 and 1978 were recruited to the Australian Longitudinal Study on Women's Health (ALSWH) via the database of the Health Insurance Commission (now Medicare; Australia's universal health insurance scheme). In 2016-2017, women in that cohort were invited to participate in the Mothers and their Children's Health Study and reported on their three youngest children (aged &lt;13 years). Data from children aged 5-12 years (n=4416) were analysed.<br /><br /> Mothers reported their children's height and weight, used to calculate body mass index (kg/m<br /><br /> ), physical activity, screen time and sleep. In the 2015 ALSWH Survey, women reported diagnoses and family history of type 2 diabetes, heart disease and hypertension. Logistic regression models determined differences between outcomes for children with and with healthy movement behaviours and maintain healthy weight.<br /><br /> Patients with uremia are prone to infection; however, end-stage renal disease (ESRD) as a risk factor for acute epiglottitis warrants study. We investigated the risk of severe epiglottitis requiring hospitalisation in patients with ESRD.<br /><br /> We conducted a retrospective matched cohort study by using the claims data of Taiwan's National Health Insurance Research Database.<br /><br /> We identified an ESRD cohort with 87 908 patients newly diagnosed in 2000-2013 and underwent dialysis. The non-ESRD cohort comprised patients who had not received a diagnosis of ESRD, and they were matches to the ESRD cohort (11) by sex, age, residence urbanisation level, monthly income, and diabetes and hypertension status.<br /><br /> The cumulative incidence of epiglottitis at the end of 2013 was analysed with Kaplan-Meier methods and log-rank tests. The HR of epiglottitis was calculated using the Cox proportional hazards model after adjustment for confounding factors.<br /><br /> The overall epiglottitis incidence rate was 94% greater in the ESRD cohort than in the non-ESRD cohort (10.3 vs 5.3 cases per 100 000 person-years, p=0.002), with an adjusted HR of 1.89 (95% CI 1.23 to 2.91, p=0.004). In the log-rank analysis, compared with the non-ESRD group, the epiglottitis cumulative incidence was significantly higher in the ESRD group (p=0.003). Epiglottitis did not exhibit an association with higher rates of airway interventions, intensive care unit admissions or longer hospitalisation in patients with ESRD than in controls.<br /><br /> This nationwide matched cohort study indicated that ESRD patients should be monitored for the risk of severe epiglottitis requiring hospitalisation.<br /><br />This nationwide matched cohort study indicated that ESRD patients should be monitored for the risk of severe epiglottitis requiring hospitalisation.