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The median duration of seizures was 50 minutes. An acute brain trigger was identified in seven patients. The subsequent neurodevelopmental deficit attributable to epileptic status was 9.1% of patients related to symptomatic etiology and/or a history of prematurity. The development of epilepsy occurred in 10.7%.<br /><br /> The neurodevelopmental disorder attributable to epileptic status affects one in 11 cases. Prematurity was a risk factor per se. Post-epileptic status epilepsy developed in one in 10 cases.<br /><br />The neurodevelopmental disorder attributable to epileptic status affects one in 11 cases. Prematurity was a risk factor per se. Post-epileptic status epilepsy developed in one in 10 cases.<br /><br /> Alzheimer's disease (AD) is the most prevalent type of dementia today, with an incidence estimated at 30% of the population over 85 years of age, which is why it represents a health problem in today's society.<br /><br /> To know if bilingualism can act as a protection factor for AD, thus increasing cognitive reserve.<br /><br /> We searched for studies in the PsychInfo, Pubmed, Psicodoc, Medline and PubPych databases, based on the combination of various terms related to the keywords. Finally, ten studies were included.<br /><br /> Seven of the ten selected studies suggest a significantly positive relationship between bilingualism and AD, although on the contrary two of the remaining studies find a partial relationship, where there is only a relationship in very specific circumstances (in the first one there is only one positive relationship when there is a low level of education, while in the second one there is only a relationship when more than two languages are spoken); only one of the studies found no significant relationship between bilingualism and AD.<br /><br /> The aforementioned studies have found a delay at the time of diagnosis or at the onset of clinically significant symptoms, between 4.5 years and 7 years; thus, bilingualism could be considered a contributing factor of the cognitive reserve and as a consequence a probable protection factor to prevent or slow the onset of AD and its subsequent progression.<br /><br />The aforementioned studies have found a delay at the time of diagnosis or at the onset of clinically significant symptoms, between 4.5 years and 7 years; thus, bilingualism could be considered a contributing factor of the cognitive reserve and as a consequence a probable protection factor to prevent or slow the onset of AD and its subsequent progression.<br /><br /> Full thickness burn wounds are lack of angiogenesis, cell migration, epithelialisation and finally scar tissue formation. Tissue engineered composite graft can provide sustained release of growth factor and promote the wound healing by cell migration, early angiogenesis and proliferation of extracellular matrix and wound remodeling. The objective of this study was to evaluate the gene embedded (pDNA-platelet-derived growth factor, PDGF-B) porcine acellular urinary bladder matrix with transfected mesenchymal stem cells (rBMSC) on healing of full thickness burn wound in rat model.<br /><br /> Full thickness burn wound of 2 × 2cm size was created in dorsum of rat model under general anesthesia. Burn wounds were treated with silver sulfadiazine; porcine acellular urinary bladder matrix (PAUBM); PAUBM transfected with pDNA-PDGF-B; PAUBM seeded with rBMSC; PAUBM seeded with rBMSC transfected with pDNA-PDGF-B in groups A, B, C, D and E respectively. The wound healing was assessed based on clinical, macroscopically, immunolomesenchymal stem cell in full thickness skin burn wound in rat.<br /><br />Gene activated matrix encoded for PDGF-B protein transfected stem cells have been clinically proven for early acceleration of angiogenesis and tissue regeneration in burn wounds in rat models. Evaluation of PDGF-B gene-activated acellular matrix and mesenchymal stem cell in full thickness skin burn wound in rat.<br /><br /> Degeneration of the annulus fibrosus (AF), an important structure of the intervertebral disc, is one of the main causes of degenerative disc disease. Fabrication of scaffolds replicating the stratified microstructure of the AF is critical for the successful regeneration of AF.<br /><br /> In this study, we cultured rabbit AF-derived stem cells (AFSCs) using fabricated electrospun fibrous poly-L-lactic acid scaffolds with different diameters. We applied cyclic tensile strain (CTS) on the scaffolds to regulate the differentiation of AFSCs into specific cell types that resided at the inner, middle, and outer zones of the AF.<br /><br /> We found that the morphologies of AFSCs on the smaller-fiber-diameter scaffolds were nearly round, whereas spindle-like cells morphologies were observed on large-diameter scaffolds. CTS enhanced these phenomena and made the cells slender. The expression levels of collagen-I in cells increased as a function of the fiber diameter, whereas collagen-II and aggrecan exhibited opposite trends. [https://www.selleckchem.com/products/md-224.html check details] Moreover, the application of CTS upregulated the gene expressions of collagen-I, collagen-II, and aggrecan.<br /><br /> Overlaying the scaffolds with different CTS-stimulated cells could eventually lead to engineered AF tissues with hierarchical structures that approximated the native AF tissue. Thus, the proposed methodologies could be potentially applied for AF regeneration.<br /><br />Overlaying the scaffolds with different CTS-stimulated cells could eventually lead to engineered AF tissues with hierarchical structures that approximated the native AF tissue. Thus, the proposed methodologies could be potentially applied for AF regeneration.<br /><br /> This study investigates the effects of a neuropeptide, secretoneurin (SN), on bone regeneration in an experimental mouse model.<br /><br /> The effects of SN on cell proliferation, osteoblast marker genes expression, and mineralization were evaluated using the CCK-8 assay, quantitative reverse transcriptase polymerase chain reaction (RT-PCR), and alizarin red S staining, respectively. To examine the effects of SN on bone regeneration in vivo, bone defects were created in the calvaria of ICR mice, and 0.5 or 1µg/ml SN was applied. New bone formation was analyzed by micro-computed tomography (micro-CT) and histology. New blood vessel formation was assessed by CD34 immunohistochemistry.<br /><br /> SN had no significant effect on proliferation and mineralization of MC3T3-E1 cells. However, SN partially induced the gene expression of osteoblast differentiation markers such as runt-related transcription factor 2, alkaline phosphatase, collagen type I alpha 1, and osteopontin. A significant increase of bone regeneration was observed in SN treated calvarial defects.