Zobrazení zdroje stránky Mckenziebojsen1048

These text-devices 'on the move' alert us not only to the role of writing and writing skills in the production of scientific knowledge, but to the role of texts as material and semiotic objects that can produce facts as well as labs and disciplines, and that are key to the accomplishment of objectivity in experimental economics.<br /><br /> The impact of a hospital formulary was evaluated to provide a guide for the establishment of local formularies to optimize patient care and healthcare costs.<br /><br /> A formulary was introduced by formulary pharmacists of the Toda Medical Group for suggesting recommended medicines to physicians based on the medication history. Patients who were hospitalized in the rehabilitation ward of the Niiza Hospital and prescribed medicines according to the formulary introduced between April 2017 and March 2018 were included and followed-up for six months.<br /><br /> Of the 183 patients screened, 154 patients were enrolled as the formulary's introduction patients (76 males/78 females, median age 78 years); 92% of these patients received formulary-proposed prescriptions at the specified timepoints; and 19 patients re-consulted at the Niiza Hospital after discharge and continued the same formulary medicines. The proposed acceptance rate by physicians was 100%. [https://www.selleckchem.com/products/Pemetrexed-disodium.html read more] Most changes suggested introduced generic formulations. The doses were equivalent for all pharmacological classes with the exception of medicines that interfere with the renin-angiotensin system, which fell from 10.7 to 7.2mg (<br /><br /> &lt; .0001). Overall daily medication costs fell at discharge compared to admission (38.5 vs. 94.6 yen per patient, respectively, <br /><br /> &lt; .0001). This was valid for all pharmacological classes except for calcium channel blockers.<br /><br /> Hospital formulary-prescribed medications continued after discharge and promoted significant decreases in costs associated with outpatient prescriptions. Introducing a hospital formulary provides a basis for the introduction of local formularies and contributes to the reduction of local healthcare costs.<br /><br />Hospital formulary-prescribed medications continued after discharge and promoted significant decreases in costs associated with outpatient prescriptions. Introducing a hospital formulary provides a basis for the introduction of local formularies and contributes to the reduction of local healthcare costs.Hypertension has become a major public health challenge and a crucial area of research due to its high prevalence across the world including the sub-Saharan Africa. No previous study in South Africa has investigated the impact of blood pressure risk factors on different specific conditional quantile functions of systolic and diastolic blood pressure using Bayesian quantile regression. Therefore, this study presents a comparative analysis of the classical and Bayesian inference techniques to quantile regression. Both classical and Bayesian inference techniques were demonstrated on a sample of secondary data obtained from South African National Income Dynamics Study (2017-2018). Age, BMI, gender male, cigarette consumption and exercises presented statistically significant associations with both SBP and DBP across all the upper quantiles (τ∈0.75,0.95). The white noise phenomenon was observed on the diagnostic tests of convergence used in the study. Results suggested that the Bayesian approach to quantile regression reveals more precise estimates than the frequentist approach due to narrower width of the 95% credible intervals than the width of the 95% confidence intervals. It is therefore suggested that Bayesian approach to quantile regression modelling to be used to estimate hypertension.Marketed lidocaine dosage forms (such as ointment, gels, and injections) used to manage acute and chronic pain showed a short duration of action ( less then 2 h). In this study, a lidocaine-loaded cubosomal gel was prepared to sustain the release of lidocaine to prolong the local anesthetic effect (high drug retention in the skin). Lidocaine-loaded cubosomal gels were prepared by melt emulsification and sonication using Pluronic F127 and DL-α-monoolein (at different levels). The cubosomal gels were characterized by morphology, size, zeta potential, entrapment efficacy, assay, viscosity, pH, and texture profiles. Ex vivo lidocaine permeation and retention studies were performed using Sprague-Dawley rat skin. Transmission electron microscopy images confirmed the bi-continuous liquid crystalline phase with a honeycomb cubosome structure. The cubosomal particle size (103-227 nm), viscosity (13,524-15,627cp), and entrapment efficacy (78.4-94.7%) increase with the level of monoolein. The ex-vivo permeation study showed a biphasic release pattern, with lidocaine cleared from ointment within 4 h (97.9% cumulative release), while cubosomal gels showed sustained release up to 24 h (53.33-98.86% cumulative release). A skin retention study demonstrated that cubosomes can increase (up to 28-fold) the lidocaine content in the skin (4.56 mg) compared to ointment (0.19 mg). A rabbit skin irritation study showed no sign of irritation after the application of cubosomal gel. In the radiant heat tail-flick study, the local anesthetic effect of lidocaine from the cubosomal gel was sustained for up to 16 h with 1.43-fold higher efficacy than marketed ointment. In conclusion, the study demonstrated the potential of cubosomal nanoparticle-laden gel to sustain the release of lidocaine for prolonging local anesthetic effects for pain management.Studies indicated that people tend to consider female-perpetrated sexual abuse (FPSA) less serious and damaging than male-perpetrated abuse (MPSA) and the possible roles of gender stereotypes on attitudes to minimize FPSA. This study aimed to explore the role of gender stereotypes and sexuality myths on the attitudes toward FPSA among professionals. A secondary aim was to explore the role of training and experience with child sexual abuse (CSA) cases on the attitudes toward FPSA. The sample consisted of Turkish professionals (N = 502), including mental health/social, health, and justice workers. The participants were recruited via a face-to-face online survey. The results of one-way ANOVAs showed that females and mental health/social workers were more likely to consider FPSA as a serious problem and believe the negative impact of abuse. A five-step hierarchical multiple regression analysis demonstrated that the experience with FPSA cases, belief in gender stereotypes, and myths about female sexuality accounted for 21.7% of the variance in the attitudes toward FPSA. Although the level of professional minimization of FPSA is above average, the influential roles of gender stereotypes and sexual myths on the attitudes toward FPSA exist among professionals. Our findings supported the necessity of additional training addressing gender stereotypes and sexual myths. Future studies should also be conducted with different populations and other influential possible factors on the attitudes toward FPSA.The design of a gas collection system (GCS) for a landfill involves estimating several critical parameters, such as the radius of influence (ROI), suction pressures, number of wells and their spacing. One of the biggest challenges lies in the estimation of ROI for a particular landfill. In this study, the ROI for a Bagalur landfill is estimated for various possible gas generation rates. ROI for active and passive GCS is estimated with numerical modelling (two-dimensional) for all definitions of ROI at different suction pressures. An inverse correlation was observed between the values of various definitions of ROI at different gas generation rates. Justification for this behaviour is brought out by addressing the conceptual difference between these definitions. The number of wells along with their spacing was then calculated, and the efficiency of the design was assessed with three-dimensional modelling. Passive and active systems had average methane recovery rates of 84% and 88%, respectively, with an atmospheric methane flux ranging from 10-9 to 10-10 kg m-2 s-1. The high recovery rate and low methane flux indicate the effectiveness of the design. The values of the methane flow rate from the extraction well were validated with a theoretical method, suggesting the usability of the model for future investigations.Adolescents' intake of vegetables and fruits is generally low, and many demonstrate unhealthy eating behaviors. Food literacy may be key to improving adolescents' nutrition. However, the relationship between food literacy, fruit and vegetable intake, and other healthy eating behaviors remains unclear, as well as how these relationships may differ among boys and girls. This study assessed the relationship between food literacy (including food skills and cooking skills), vegetable and fruit consumption, and other eating behaviors of adolescents. This cross-sectional study included 1,054 students, including 467 boys and 570 girls from five francophone high schools in New Brunswick, Canada. Quantitative data on students' food and cooking skills, vegetable and fruit consumption, and other eating behaviors were collected with a self-reported questionnaire. Multilevel regressions were used to assess the relationship between food literacy, students' consumption of vegetables and fruits, and other eating behaviors. Better cooking skills were associated with healthier eating behaviors and greater vegetable and fruit consumption for boys and girls. Better food skills were also associated with healthier eating behaviors and greater vegetable and fruit consumption among both genders. These findings highlight the importance of improving food literacy among adolescents. Public health interventions should focus on increasing cooking and food skills to improve adolescents' nutrition.<br /><br /> Prior studies suggest steroid injections may affect infection rates following thumb carpometacarpal joint (CMCJ) arthroplasty. However, it is unclear whether injections prior to CMCJ arthroplasty affect functional outcomes, primarily Quick Disabilities of the Arm, Shoulder, and Hand (qDASH).<br /><br /> We retrospectively identified patients who underwent thumb CMCJ arthroplasty from 2015 to 2019. Patients who had qDASH scores reported preoperatively, and at 5 and 11 months postoperatively were included. Charts were reviewed for the presence or absence of prior corticosteroid injection to the CMCJ and complications. Delta qDASH was calculated by subtracting the patients' postoperative qDASH scores from the preoperative qDASH scores.<br /><br /> In all, 350 CMCJ arthroplasty patients were identified, 177 who had received at least 1 steroid injection and 173 who were steroid-naïve. No significant differences existed in delta qDASH scores postoperatively between the injection and naïve groups at 5 months (28.5 vs 28.6) or 11 months (31.2 vs 31.9). Whereas there were no significant differences in rates of major complications between the 2 groups, minor complications were higher in the injection group (16.4% vs 9.2%). Patients who received more than 3 injections did not have worse 5-month or 11-month delta qDASH scores or complication rates than those with fewer than 3.<br /><br /> Preoperative CMCJ steroid injection status does not affect major complication rates or functional outcomes following CMCJ arthroplasty. However, injections increase the rate of minor complications. The qDASH and complication rates following CMCJ arthroplasty are not affected by receiving greater than 3 injections preoperatively.<br /><br />Preoperative CMCJ steroid injection status does not affect major complication rates or functional outcomes following CMCJ arthroplasty. However, injections increase the rate of minor complications. The qDASH and complication rates following CMCJ arthroplasty are not affected by receiving greater than 3 injections preoperatively.