Zobrazení zdroje stránky Mckennabarnes6198

Intradialytic calcium influx was determined by dialysate calcium concentration and predialysis serum calcium levels, whereas intradialytic phosphate elimination was determined by predialysis serum phosphate levels.<br /><br /> Small sample size and no control groups treated with 2.5- and 3.0-mEq/L dialysate calcium concentrations during the 24 weeks of the observation period.<br /><br /> Conversion of dialysate calcium concentration from either 3.0 or 2.5 to 2.75 mEq/L results in expected changes in calcium loading based on predialysis calcium concentration. The dialysate calcium concentration should be personalized based on clinical factors.<br /><br /> None.<br /><br /> University Hospital Medical Information Network, www.umin.ac.jp/english/, R000040105, UMIN000035184.<br /><br />University Hospital Medical Information Network, www.umin.ac.jp/english/, R000040105, UMIN000035184.<br /><br /> Timely recognition of functional decline in older adults receiving dialysis will allow clinicians to pursue interventions to prevent further disability and/or lead patient-centered goals of care discussions. Annual change in the 12-Item Short Form Health Survey (SF-12) physical component score (PCS) could identify patients with functional decline. Our objectives were to assess SF-12 PCS change over a year, risk factors associated with SF-12 PCS change, and the association of SF-12 PCS change with mortality in a survivor cohort of older adults receiving dialysis.<br /><br /> Retrospective study.<br /><br /> 1,371 adults 65 years or older receiving hemodialysis for 6 or more months who completed SF-12 PCSs 300 or more days apart from 2012 to2013.<br /><br /> Serum albumin level; hemodialysis access type; SF-12 PCS change (for mortality analyses).<br /><br /> SF-12 PCS change and mortality.<br /><br /> Multivariable-adjusted linear regression model; Cox proportional hazards model.<br /><br /> We excluded 24% (n= 801) of our cohort for death before the second SF-12 PCS.ivors, it was more common for SF-12 PCS to decline than improve in a year. Annual SF-12 PCS change was not associated with traditional risk factors for functional impairment or mortality risk. Additional research is needed to identify appropriate measures and frequency of assessment for functional decline.<br /><br /> The accuracy of glycated hemoglobin (HbA<br /><br /> ) level for assessment of glycemic control in patients with chronic kidney disease (CKD) is uncertain. This study assessed the accuracy of HbA<br /><br /> level using continuous glucose monitoring.<br /><br /> Diagnostic test study of HbA<br /><br /> and serum fructosamine. The continuous glucose monitor was worn for 14 days. Glucose was measured every 15 minutes (up to 1,344 measurements). Average glucose concentration was calculated for each patient from the patient's continuous glucose monitor measurements. Linear regression was applied to estimate the relationship between average glucose concentration and HbA<br /><br /> and serum fructosamine levels. The influence of patient characteristics on the relationship between HbA<br /><br /> and average glucose concentrations was examined in a multivariate regression model.<br /><br /> Patients with type 2 diabetes and CKD (estimated glomerular filtration rate, 7-45mL/min, not receiving dialysis) seen in an academic nephrology clinic.<br /><br /> The accuracy of HbA<br /><br /> level for assessmen of glycemic status among patients with CKD and type 2 diabetes. This relationship appears to hold true among patients with more severe CKD.<br /><br />HbA1c is an accurate measure of glycemic status among patients with CKD and type 2 diabetes. This relationship appears to hold true among patients with more severe CKD.<br /><br /> Epoetin alfa-epbx is a biosimilar to the reference product, epoetin alfa. We compare the safety of epoetin alfa-epbx versus epoetin alfa based on a pooled analysis of findings from 2 randomized, double-blind, comparative clinical studies, and report new data for the long-term safety of epoetin alfa-epbx.<br /><br /> Pooled analyses of previously conducted studies.<br /><br /> Hemodialysis patients with anemia.<br /><br /> Data from patients who received 1 or more subcutaneous or intravenous doses of study drug were integrated across route of administration in combined randomized groups (epoetin alfa-epbx, n= 423; epoetin alfa, n= 426). Data from patients who received 1 or more doses of epoetin alfa-epbx in either open-label extension trial were integrated across route of administration in a combined long-term safety studies group (n= 576).<br /><br /> Adverse events (AEs), immunogenicity, and other outcomes were assessed.<br /><br /> Incidences of treatment-emergent AEs, serious AEs, and discontinuation of study drug treatment because of treatment-emergenthe open-label long-term safety studies.<br /><br /> This analysis reinforces previous conclusions of similar safety profiles between epoetin alfa-epbx and epoetin alfa. [https://www.selleckchem.com/products/sodium-bicarbonate.html Sodium Bicarbonate] Furthermore, epoetin alfa-epbx had no unexpected safety signals during long-term treatment.<br /><br /> This study was funded by Hospira Inc, which was acquired by Pfizer Inc in September2015.<br /><br /> ClinicalTrials.gov EPOE-10-13 (NCT01473420); EPOE-10-01 (NCT01473407); EPOE-11-04 (NCT01628120); EPOE-11-03 (NCT01628107).<br /><br />ClinicalTrials.gov EPOE-10-13 (NCT01473420); EPOE-10-01 (NCT01473407); EPOE-11-04 (NCT01628120); EPOE-11-03 (NCT01628107).<br /><br /> Arteriovenous fistulas are the preferred access type for hemodialysis. The buttonhole needling technique has become an alternative to stepladder or area puncture. However, an increased risk for infection has been described. The present study examined the risk for infectious complications with different needling techniques.<br /><br /> Prospective multicenter observational cohort study with 5 years of follow-up.<br /><br /> In-center hemodialysis patients from 5 hemodialysis units in Denmark, dialyzed on a native arteriovenous fistula. 286 patients were included; 144 cannulated with the buttonhole technique.<br /><br /> The buttonhole cannulation technique was compared to the stepladder or area puncture technique.<br /><br /> Primary end points event rates of access-related <br /><br /> bacteremia and the HR for first access-related <br /><br /> bacteremia. Secondary end points local infections and access-related <br /><br /> bacteremia-related metastatic infections and mortality.<br /><br /> Time-to-event analysis using Cox proportional hazards regression to estimate the HR of access-rice. A restrictive approach to buttonhole use is recommended, with buttonhole cannulation only being used as a second alternative to area technique when stepladder cannulation is not feasible.<br /><br />Access-related S aureus bacteremia rates were very high for buttonhole cannulation compared to stepladder/area needling, questioning the use of buttonhole cannulation in routine clinical practice. A restrictive approach to buttonhole use is recommended, with buttonhole cannulation only being used as a second alternative to area technique when stepladder cannulation is not feasible.