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Electronic medical record (EMR)-based suicide risk prediction methods typically rely on analysis of structured variables such as demographics, visit history, and prescription data. Leveraging unstructured EMR notes may improve predictive accuracy by allowing access to nuanced clinical information. We utilized natural language processing (NLP) to analyze a large EMR note corpus to develop a data-driven suicide risk prediction model. We developed a matched case-control sample of U.S. Department of Veterans Affairs (VA) patients in 2015 and 2016. We randomly matched each case (all patients that died by suicide in that interval, n = 5029) with five controls (patients that remained alive). We processed note corpus using NLP methods and applied machine-learning classification algorithms to output. We calculated area under the curve (AUC) and risk tiers to determine predictive accuracy. NLP-derived models demonstrated strong predictive accuracy. Patients that scored within top 10% of risk model accounted for up to 29% of suicide decedents. NLP-derived model compares positively to other leading prediction methods. Our approach is highly implementable, only requiring access to text data and open-source software. Additional studies should evaluate ensemble models incorporating NLP-derived information alongside more typical structured variables.Today, many women are driven to subscribe to a more athletically oriented appearance ideal hallmarked by muscle tone (referred to as athletic- or fit-looking). However, the constellation of unhealthy eating and exercise behaviors that may accompany the pursuit of toned muscularity among women is not yet well characterized. To address this knowledge gap, our study evaluated the associations among the female drive for toned muscularity and both thinness-oriented disordered eating behaviors (e.g., dietary restriction) and muscularity-oriented disordered eating behaviors (e.g., excessive scrutiny of macro-nutrient values of food), as well as dimensions of compulsive exercise. Participants were 388 Australian undergraduate women who completed an online questionnaire including self-report measures of said constructs. Hierarchical regression models were used to determine whether the drive for toned muscularity accounted for unique variance in eating and exercise behaviors after adjusting for theoretically relevant covariates. Results indicated independent relationships between the drive for toned muscularity and several facets of thinness- and muscularity-oriented disordered eating, as well as compulsive exercise (e.g., exercise rigidity). Our findings further contribute to an emerging literature illustrating that women driven to attain a toned appearance may be vulnerable to engaging in a wide range of maladaptive eating and exercise practices.Beauty content on social media has grown exponentially, however research has yet to investigate its association with appearance concerns. This study drew on components of the tripartite influence model to test the associations between young women's engagement with beauty content on social media and cosmetic surgery consideration. A sample of 399 undergraduate women aged 17-25years (Mage = 19.36) completed measures of beauty social media engagement, upward appearance comparison, general attractiveness internalization, dysmorphic appearance concerns, and consideration of cosmetic surgery. Path analysis was used to test direct and indirect associations. In line with the tripartite influence model, results supported a serial mediation model that comprised significant paths from beauty social media engagement through in turn, upward appearance comparison, general attractiveness internalization, and dysmorphic appearance concerns, to cosmetic surgery consideration. However, neither general attractiveness internalization nor dysmorphic appearance concerns mediated the link between beauty social media engagement and consideration of cosmetic surgery. Findings provide new insights into the links between engagement with the growing beauty social media trend and cosmetic surgery consideration.Positive body image may be particularly relevant to assess for Brazilian gay and bisexual men, given the extent of sexual minority stressors (e.g., harassment, discrimination) in Brazilian culture, which can impair one's self-perception and concept. Thus, the purpose of the present study was to assess the psychometric properties of the Body Appreciation Scale-2 (BAS-2) among Brazilian cisgender gay and bisexual adult men, aged 18-50 years. We evaluated the factor structure using a two-step, split-sample exploratory (EFA; n = 682) and confirmatory factor analytic approach (CFA; n = 727), which supported the one-factor structure of the measure. Additionally, convergent validity, internal consistency, and 2-week test-retest reliability were assessed. [https://www.selleckchem.com/products/AZD5438.html AZD5438] The BAS-2 scores showed small to large negative correlations with self-objectification beliefs and behaviors, drive for muscularity and appearance-ideal internalization measures. We also found good internal consistency and test-retest reliability of the measure. Taken together, these results support the use of the BAS-2 in Brazilian cisgender gay and bisexual men and provide an initial understanding of body appreciation and other related constructs among this population.Despite frequently co-occurring, the temporal relationship between depression and eating disorder symptoms remains poorly understood. This exploratory study sought to investigate the reciprocal relationship between depressive symptoms and (1) shape and weight dissatisfaction, (2) shape and weight overvaluation, (3) preoccupation with shape or weight, (4) preoccupation with food, (5) dietary restraint and (6) binge eating in early adolescence. Adolescents (N = 1393) aged between 11.4 and 13.9 years (M = 12.50, SD = 0.38) completed the Centre for Epidemiological Depression Scale-Revised and Eating Disorder Examination Questionnaire-Adolescent version at the beginning of secondary school (T1) and 12-months later (T2). Cross-lagged models were created to assess the reciprocal relationship between depressive symptoms and ED symptoms. Depressive symptoms at T1 predicted shape and weight dissatisfaction, shape and weight overvaluation, preoccupation with shape or weight, preoccupation with food, dietary restraint and binge eating at T2. Shape and weight dissatisfaction and binge eating were the only ED symptoms at T1 to predict depressive symptoms at T2. Findings suggest young adolescents who experience depressive symptoms in their first year of secondary school are at-risk of developing ED symptoms over the subsequent 12-month period.Pseudorabies virus (PRV) is a swine herpesvirus with a broad host range that causes significant economic losses worldwide. The Wnt/β-catenin signaling pathway is reportedly involved in multiple viruses' proliferation. In this study, we demonstrated that PRV infection significantly activated the Wnt/β-catenin signaling and promoted the nuclear translocation of β-catenin. Applying specific chemical inhibitors (FH535 and iCRT14) caused a remarkable decrease in PRV titers in various cell lines. Knockdown of β-catenin by siRNA also reduced the proliferation of PRV. On the contrary, treatment with lithium chloride (LiCl), an inhibitor of GSK3β, stimulated the Wnt/β-catenin signaling pathway and enhanced the PRV proliferation. Similarly, overexpression of β-catenin promoted PRV proliferation and reversed the antiviral effect of FH535. Moreover, LiCl promoted PRV-induced autophagy, whereas FH535 and iCRT14 showed converse effects. These findings suggest that PRV infection stimulates the canonical Wnt/β-catenin signaling pathway, facilitating PRV proliferation and regulating virus-induced autophagy. These data also provide potential targets for developing antiviral agents against PRV.Existing pharmacological treatments for psychiatric disorders have demonstrated limited efficacy, delayed onset of action, and significant burden of side effects. Recent findings from human studies with psychedelics have shown promise, demonstrating rapid and sustained clinical benefits of these compounds for a variety of psychiatric disorders. Classical psychedelics have a rich history and some of these compounds have been used in shamanic and spiritual ceremonies for millennia. The psychoactive effects of these drugs, particularly on human consciousness, have generated great scientific curiosity, and early research on psychedelics suggested their clinical benefits for psychiatric conditions, including alcohol use disorders and anxiety and depressive symptoms in terminal illness and life-threatening conditions. Since the 1990s, after a period of dormancy that followed the criminalization of psychedelic drugs since the Controlled Substance Act of 1970, the continued interest in their unique psychoactive effects along with the pursuit for novel and more effective treatments in psychiatry have led to a renewed interest in research on these compounds. While preliminary findings on psychedelics are encouraging, current evidence is still insufficient to support extensive use of these drugs routinely. Long-term safety and efficacy of these compounds remain unclear, and several clinical trials are underway and may add clarity to these questions. Therefore, this article intends to provide an overview of the evidence to date on psychedelic drugs - particularly psilocybin, MDMA, and LSD - for the treatment of psychiatric disorders.<br /><br /> This research aims to investigate the utility of the Near Infra-Red (NIR) photographic technique in visualizing forensic evidence in a post-mortem examination.<br /><br /> A total of twenty-six deceased (male n=15; female n=11) were brought to the Mortuary of King George's Medical University, Chowk, Lucknow, Uttar Pradesh, India (226003), and were used to investigate the applicability of the human visible spectrum (HVS) &amp; near-infrared photography. In the investigation, a modified Nikon D5300 crop-framed digital single-lens reflex camera was used for NIR Photography in combination with a Micro-Nikkor 105mm, f/2.8, (Nikon Inc., Melville, NY, USA), Hoya R72 (760nm-860nm) infrared filter and a Nikon D5600 crop-framed digital single-lens reflex camera in combination with Nikkor 50mm lens for Human Visible Spectrum (HVS) Photography.<br /><br /> The finding of the study reported that the application of the NIR photography would be the best of the investigative techniques for visualization and photo-documentation of forensically the NIR Photography in combination with indirect sunlight &amp; room light as an infrared light source. (At a wavelength of 760nm-860nm).Biobanking plays a critical role in diagnostics, biomarker research and development of novel treatment approaches for various diseases. In urgent need of understanding, preventing and treating coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the importance of biobanking including data sharing and management further increased. To provide high quality tissue biomaterials and data for research and public health, the COVID-19 Autopsy and Biosample Registry was established in the state of Baden-Wuerttemberg (BW) in Germany, combining expertise and technologies of the Institutes of Pathology of the five university hospitals in BW (Heidelberg, Tübingen, Ulm, Freiburg, Mannheim). The COVID-19 Autopsy and Biosample Registry BW comprises tissue samples from autopsies and associated data of deceased patients in the context of SARS-CoV-2 infection and/or vaccination against SARS-CoV-2. The aim is to collect autopsy biospecimens, associated clinical and diagnostic data in a timely manner, register them, make them accessible for research projects and thus to support especially tissue-related research addressing COVID-19.