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A perspective of the potential issues of metal-free ODH catalytic systems in terms of their rational design and their synergy with reactor engineering was sketched.Chemical doping engineering is an effective strategy to modify the hole transport layer (HTL) and achieve high-efficiency perovskite solar cells (PSCs). In this work, we synthesize an infrequent trilacunary Keggin type polyoxometalate Na10[Zn2(H2O)6(WO2)2(BiW9O33)2] (BiW9-Zn) and apply it as an additive to enhance the hole mobility and electrical conductivity of Spiro-OMeTAD based HTLs. Thanks to the strong electron-accepting properties of polyoxometalate molecules, the as-synthesized BiW9-Zn can directly oxidize Spiro-OMeTAD under an inert atmosphere and avoid the tedious long-term oxidation process. Therefore, the power conversion efficiency (PCE) of optimal PSCs with BiW9-Zn doping is enhanced from 17.58% (without doping) to 19.56% with a significantly improved fill factor and open-circuit voltage. In addition, the assembly repeatability and long-term stability of PSCs are also improved. This work demonstrates the potential of using polyoxometalates (POMs) as low-cost, efficient and highly flexible chemical dopants for HTLs, and more importantly paves a new route to enhance the performance of PSCs.Emerging evidence shows that amino acids can modulate lipid metabolism. Aromatic amino acids (AAAs) serve as important precursors of several neurotransmitters and metabolic regulators that play a vital role in regulating nutrient metabolism. But whether AAAs have a lipid-lowering function remains unknown. Here mice were fed amino acid-defined diets containing AAAs at 1.82% and 3.64% for 3 weeks. We demonstrated that double AAA intake significantly decreased the serum and hepatic triglycerides and serum low-density lipoprotein cholesterol, but increased the high-density lipoprotein cholesterol as well as insulin tolerance. Combined metabolomic and transcriptomic analysis showed that the hepatic acidic pathway of bile acid synthesis was responsible for the improvement in lipid metabolism by AAA treatment. This study suggests that AAAs have the potential to ameliorate steatosis and provides a new alternative to improve lipid metabolism.Despite widespread development and use of ionic liquids (ILs) in both academic and industrial research, computational force fields (FFs) for most of those are not available for a precise description of inter-species interactions in aqueous environments. In the scope of this study, by means of molecular simulations, the osmotic coefficient of an aqueous solution of an IL is calculated and used as a basis to reparameterize popular IL-FFs existing in the literature. We first calculate the osmotic coefficients (at 298.15 K and 1 atm pressure) of aqueous solutions of 1-butyl-3-methylimidazolium chloride (BMIMCl), a generic IL, popularly used in biomass processing and the subsequent conversion to value-added intermediates. The performance of two popular atomic, nonpolarizable FFs developed for BMIMCl, one by Lopes, Pádua, and coworkers (FF-LP) and the other by Sambasivarao, Acevedo, and coworkers (FF-SA), when mixed with the SPC/E water model, is tested with respect to their ability to reproduce the experimental osexperimental solution properties, such as density, viscosity, association/dissociation, etc. We report that excessive dissociation of BMIMCl in water is responsible for the shortcomings observed in the original FFs and improved prediction of physicochemical properties could be achieved using the modified FFs.Here, we synthesized a valence tautomeric cobalt-dioxolene complex featuring a protected anchoring group. At room temperature, the complex reveals a nearly pure low-spin-Co(iii)-catecholate state in the solid state, but a nearly pure high-spin-Co(ii)-semiquinonate state in toluene solution. Thermal switchability of the complex in solution and in the solid state is investigated.At present, cancer is obviously a major threat to human health worldwide. Accurate diagnosis and treatment are in great demand and have become an effective method to alleviate the development of cancer and improve the survival rate of patients. A large number of theranostic probes that combine diagnosis and treatment methods have been developed as promising tools for tumor precision medicine. Among them, fluorescent theranostic probes have developed rapidly in the frontier research field of precision medicine with their real time, low toxicity, and high-resolution merit. [https://www.selleckchem.com/products/mira-1.html MIRA-1 concentration] Therefore, this review focuses on recent advances in the development of fluorescent theranostic probes, as well as their applications for cancer diagnosis and treatment. Initially, small-molecule fluorescent theranostic probes mainly including tumor microenvironment-responsive fluorescent prodrugs and phototherapeutic probes were introduced. Subsequently, nanocomposite probes are expounded based on four types of nano-fluorescent particles combining different therapies (chemotherapy, photothermal therapy, photodynamic therapy, gene therapy, etc.). Then, the capsule-type "all in one" probes, which occupy an important position in theranostic probes, are summarized according to the surface carrier type. This review aims to present a comprehensive guide for researchers in the field of tumor-related theranostic probe design and development.Mitochondrial dysfunction, oxidative stress and inflammation are crucial contributors to liver damage and nonalcoholic fatty liver disease (NAFLD) in adulthood in offspring affected by intrauterine growth retardation (IUGR). Resveratrol (RSV) has been reported to treat and/or prevent hepatic diseases under various pathological conditions. However, the therapeutic and/or preventive effects of RSV on hepatic abnormality in IUGR adults have not been investigated until now. The effects of IUGR and RSV on the hepatic metabolic status, mitochondrial function, redox homeostasis and inflammation in pigs in adulthood were investigated. A total of 36 pairs of IUGR and normal birth weight piglets were orally fed with 80 mg RSV per kg body weight per d or vehicle (0.5% carboxymethylcellulose) for 7-21 d after birth. And then the offspring were fed with a basal diet supplemented with 300 mg RSV per kg feed or a basal diet from weaning to slaughter at 150 d. The plasma and liver samples were collected for subsequent analysis.