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The 24–48 h KIM-1 levels of the cases with exitus were higher (P = 0.007). The 24–48 h cystatin C and preoperative NGAL levels were higher in patients with postoperative AKI (P = 0.02).<br /><br /> In newborns with CCHD, high KIM-1 levels may predict mortality, whereas high cystatin C and preoperative NGAL levels may be indicative of AKI. These biomarkers deserve further investigation in larger study populations.<br /><br />In newborns with CCHD, high KIM-1 levels may predict mortality, whereas high cystatin C and preoperative NGAL levels may be indicative of AKI. These biomarkers deserve further investigation in larger study populations.<br /><br /> Drug provocation test (DPT) is the gold standard method that is performed at the end of a stepwise approach in drug allergy work up. DPT is administered with a single drug on a test day. Testing more than one drug in a day would be a feasible option, time and manpower saving and safe procedure in well selected patients. Aim of the present study was to investigate efficacy and safety of performing DPT with two or three alternative drugs in one test day (Hacettepe Method).<br /><br /> Between August 2010 and December 2016, adult patients who have been admitted with drug hypersensitivity, and DPTs have been performed with the described method were included. The method was based on performing DPT with two or three different, alternative drugs on the same test day. Data was obtained from standard drug provocation test forms, and from patients? files.<br /><br /> A total of 1448 DPTs have been performed by Hacettepe Method to 1131 patients. Reaction rate was 5.45% (n= 79), none of them being severe. Hacettepe method saved 19.95 DPTs a month which was a considerable amount of time.<br /><br /> In case of proven drug hypersensitivity reaction, performing a drug provocation test with a combination of two or three different alternative drugs instead of one saved time, manpower, and was a safe procedure. We recommend the method to be implemented in drug allergy work up.<br /><br />In case of proven drug hypersensitivity reaction, performing a drug provocation test with a combination of two or three different alternative drugs instead of one saved time, manpower, and was a safe procedure. We recommend the method to be implemented in drug allergy work up.<br /><br /> Coronavirus 2019 disease (Covid-19) was first seen in December 2019 and afterwards it became a pandemic. Several systemic involvements have been reported in Covid-19 patients. In this study, it was aimed to investigate the cerebrovascular hemodynamics in patients with Covid-19.<br /><br /> The sample of this study was conducted on 20 patients hospitalized in our clinic diagnosed with Covid-19 via PCR modality and 20 healthy volunteers of similar age and sex. Bilateral middle cerebral arteries were investigated with Transcranial Doppler Ultrasonography. [https://www.selleckchem.com/pharmacological_epigenetics.html Epigenetic inhibitor] Basal serebral blood flow velocities and vasomotor reactivity rates were determined and compared as statistically.<br /><br /> When patient and control groups were compared, the mean blood flow velocity was found to be higher in Covid-19 patients than the healthy volunteers and it was statistically significant (p = 0.00). The mean vasomotor reactivity rates values were found to be lower in Covid-19 group than the healthy group and also it was statistically significant (p = 0.00).<br /><br /> An increase in cerebral basal blood velocity and a decrease in vasomotor reactivity rates in patients with Covid-19 can be considered as an indicator of dysfunction of cerebral hemodynamics in central nervous system and this can be evaluated as a result of endothelial dysfunction.<br /><br />An increase in cerebral basal blood velocity and a decrease in vasomotor reactivity rates in patients with Covid-19 can be considered as an indicator of dysfunction of cerebral hemodynamics in central nervous system and this can be evaluated as a result of endothelial dysfunction.<br /><br /> The study aimed to investigate the effect of training on hearing aid users to benefit from induction loop systems.<br /><br /> A five-question scale was developed to evaluate whether individuals using hearing aids could use the induction loop system effectively. In the first step, validity-reliability studies were performed with 264 individuals using hearing aids. In the second step, 30 individuals using hearing aids were given verbal and hands-on training on the induction loop system. Before and after training with hearing aids (noiseless, noise, noise + induction system active) in three different environments, questions on the scale were asked twice in total from the beginning to the end of the study.<br /><br /> The significance of the differences between the values obtained as a result of the application of word lists in three different test settings was examined by repeating the measurements variance analysis. As a result of the post hoc analysis, P = 0.002 between test 3 (10.7, 1.53) and test 1 (11.7, 0.7) was calculated. There appears to be a statistically significant difference with the present situation (P &lt; 0.01). The average scores of the scale between pre and posttraining applications as a preliminary and final test were analysed with a t-test. The final test average was statistically significantly greater than the preliminary test (P &lt; 0.01).<br /><br /> This study shows how important it is for hearing aid users to be informed and to receive the necessary training in order to gain the expected benefit from induction loop systems developed to improve speech intelligibility in noisy environments.<br /><br />This study shows how important it is for hearing aid users to be informed and to receive the necessary training in order to gain the expected benefit from induction loop systems developed to improve speech intelligibility in noisy environments.<br /><br /> The evolving understanding of essential tremors (ET) has led to a new definition of neurodegenerative disease, pointing to diffuse brain network involvement with a wide spectrum of associated motor and nonmotor symptoms. Considering the fact that white matter should also be affected by the nature of the disease, our study aimed to evaluate the integrity of white matter and its clinical correlations in ET patients.<br /><br /> Approximately 40 patients diagnosed with ET and 40 age-and sex-matched control subjects (ranging between 18–80 years old) were included in the study. The sociodemographic characteristics and clinical features of the patients were recorded. Tremors were assessed using the Fahn-Tolosa-Marin Tremor Rating Scale (FTM-TRS). Diffusion Tensor Imaging (DTI) was performed to evaluate the integrity of white matter. The selected white matter regions used for DTI assessment were the corpus callosum (CC) (i.e., the largest commissural tract in the human brain), the superior longitudinal fasciculus (SLF), and the inferior longitudinal fasciculus (ILF) (i.