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ormed using easily obtained clinical and ECG features. This cost-effective strategy may be a valuable first clinical step for assessing the presence of LV dysfunction and may potentially aid in the early diagnosis and management of heart failure patients.<br /><br /> Pulmonary artery denervation (PADN) procedure has not been applied to patients with residual chronic thromboembolic pulmonary hypertension (CTEPH) after pulmonary endarterectomy (PEA).<br /><br /> This study sought to assess the safety and efficacy of PADN using remote magnetic navigation in patients with residual CTEPH after PEA.<br /><br /> Fifty patients with residual CTEPH despite medical therapy at least 6months after PEA, who had mean pulmonary artery pressure≥25mmHg or pulmonary vascular resistance (PVR) &gt; 400 dyn‧s‧cm<br /><br /> based on right heart catheterization were randomized to treatment with PADN (PADN group; n=25) using remote magnetic navigation for ablation or medical therapy with riociguat (MED group; n=25). In the MED group, a sham procedure with mapping but no ablation was performed. The primary endpoint was PVR at 12months after randomization. Key secondary endpoint included 6-min walk test.<br /><br /> After PADN procedure, 2 patients (1 in each group) developed groin hematoma that resolved without anyconsequences. At 12months, mean PVR reduction was 258 ± 135 dyn‧s‧cm<br /><br /> in the PADN group versus 149±73dyn‧s‧cm<br /><br /> in the MED group, mean between-group difference was 109 dyn‧s‧cm<br /><br /> (95% confidence interval 45 to 171; p=0.001). The 6-min walk test distance was significantly increased in the PADN group as compared to distance in the MED group (470 ± 84m vs. [https://www.selleckchem.com/products/ck-666.html click here] 399 ± 116 m, respectively; p=0.03).<br /><br /> PADN in patients with residual CTEPH resulted in substantial reduction of PVR at 12months of follow-up, accompanied by improved 6-min walk test.<br /><br />PADN in patients with residual CTEPH resulted in substantial reduction of PVR at 12 months of follow-up, accompanied by improved 6-min walk test.<br /><br /> Acute pulmonary embolism (PE) is associated with high morbidity and mortality because of right ventricular (RV) failure. There is evidence suggesting surgical therapy (surgical embolectomy or venoarterial extracorporeal membrane oxygenation [ECMO]) is safe and effective.<br /><br /> The aim of this study was to assess the safety and efficacy of surgical management of acute PE.<br /><br /> Surgical embolectomy and/or venoarterial ECMO were compared, between 2005 and 2019, for massive PE (MPE) versus high-risk submassive PE (SMPE). RV recovery was defined as improvements in central venous pressure, pulmonary artery systolic pressure, RV/left ventricular ratio, and RV fractional area change.<br /><br /> One hundred thirty-six patients with PE (92 with SMPE and 44 with MPE) were identified. Patients with MPE more often presented with syncope (59.1% [26 of 44] vs. 25.0% [23 of 92]; p=0.0003), Glasgow Coma Scale score≤4 (22.7% [10 of 44] vs. 0% [0 of 92]), and failed thrombolysis (18.2% [8 of 44] vs. 4.3% [3 of 92]; p=0.008). Pre-operative cardiopulmonary resuscitation occurred in 43.2% of patients with MPE (19 of 44). Most patients with SMPE were treated with embolectomy (98.9% [91 of 92]), while ECMO was used more in those with MPE (ECMO in 40.9% [18of 44], embolectomy in 59.1% [26 of 44]). RV function improved as measured by central venous pressure (from 23.4 ± 4.9 to 10.5 ± 3.1mmHg), pulmonary artery systolic pressure (from 60.6 ± 14.2 to 33.8 ± 10.7mmHg), RV/left ventricular ratio (from 1.19 ± 0.33 to 0.87 ± 0.23; p&lt;0.005), and fractional area change (from 26.8 to 41.0; p&lt;0.005). Mortality was 4.4% (6 of 136; SMPE, 1.1% [1 of 92]; MPE, 11.6% [5 of 44]). Subgroup analysis showed morbidity and mortality were highly associated with pre-operative cardiopulmonary resuscitation.<br /><br /> Surgical management of patients with MPE and high-risk SMPE is safe and highly effective at achieving RV recovery.<br /><br />Surgical management of patients with MPE and high-risk SMPE is safe and highly effective at achieving RV recovery.<br /><br /> The poorer prognosis of coronary artery disease in females compared with males is related mainly to differences in baseline characteristics. In the SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) trial, the effect of treatment with percutaneous coronary intervention (PCI) versus coronary artery bypass grafting surgery (CABG) on mortality at 5 years differed significantly between females and males; however, the optimal revascularization beyond 5 years according to sex has not been evaluated.<br /><br /> The aim of this study was to investigate the impact of sex on mortality and sex-treatment interaction at 10 years.<br /><br /> The SYNTAXES (SYNTAX Extended Survival) study evaluated vital status up to 10 years in 1,800 patients with de novo 3-vessel and/or left main coronary artery disease randomized to treatment with PCI or CABG in the SYNTAX trial. All-cause death at 10 years was separately evaluated in female and male patients with complex coronary artery disease.<br /><br /> Of 1,800 patient theTreatment of Narrowed Arteries [SYNTAX], NCT00114972).<br /><br />Female sex was not an independent predictor of mortality at 10 years in patients with complex coronary artery disease. The interaction between sex and treatment with PCI or CABG that was observed at 5 years was no longer present at 10 years. (Synergy Between PCI With TAXUS and Cardiac Surgery SYNTAX Extended Survival [SYNTAXES], NCT03417050; SYNTAX Study TAXUS Drug-Eluting Stent Versus Coronary Artery Bypass Surgery for the Treatment of Narrowed Arteries [SYNTAX], NCT00114972).<br /><br /> During the recent decade, many outbreaks of infectious diseases have been reported at increasing scales and frequency. The novel COVID-19 is the most recent lethal virus and has been declared to be a pandemic disease on March 11th, 2020. It has spread from China to most of the countries around the world causing a great burden on individuals and communities. The socioeconomic and professional profiles have been affected seriously by this pandemic. The aim of this study was to assess the short-term effects of COVID-19 on the socioeconomic profile of spinal surgeons in Egypt.<br /><br /> We conducted a cross-sectional online survey study to address the effect of COVID-19 global pandemic on spine surgeons in Egypt, discussing the short-term socioeconomic effect of COVID-19 global pandemic on the professional and social profiles of the Egyptian spine surgeons. A SurveyMonkey<br /><br /> questionnaire was sent to 190 spine surgeons registered in the Egyptian spine association database.<br /><br /> Ninety male surgeons responded to our four-day survey.