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Our findings support the utility of control balance theory in explaining an act of submission (i.e., playing through pain and injury).<br /><br /> Like other combat sports, sambo has competition rules that divide athletes into categories based on gender, age and weight. Athletes in combat sports often resort to rapid weight loss (RWL) methods to be more competitive in lower weight categories and gain an advantage against lighter, smaller and weaker competitors. The aim of this study was to examine the methodology implemented by two different sambo age categories, junior and senior athletes, in order to attain RWL.<br /><br /> The sample consisted of 103 male sambo elite athletes (seniors/juniors age 28.5 ± 4.3/18.9 ± 0.8; height (m) 1.7 ± 0.1/1.8 ± 0.1; weight (kg) 76.3 ± 17.8/74.4 ± 16.3; BMI (kg/m<br /><br /> ) 25.0 ± 3.8/23.7 ± 3.9) who completed a survey on RWL.<br /><br /> Athletes reported losing a mean of 5 kg starting approximately 12 days before a competition. The most common methodology reported by senior and junior sambo athletes was gradually increasing dieting, followed by sauna and plastic suit training. Less common methods adopted were laxatives, diuretics, the use of diet pills and vomiting. There were significant group differences for sauna and diet pill ingestion. Coaches and parents are influential people in the lives of athletes concerning the weight loss strategy to be adopted.<br /><br /> This study's results unequivocally confirm the prevalent practice of RWL in both senior and junior sambo athletes. Although athletes prevalently chose "less harmful" methods, there is a need to inform parents and coaches of the risks and benefits of RWL.<br /><br />This study's results unequivocally confirm the prevalent practice of RWL in both senior and junior sambo athletes. Although athletes prevalently chose "less harmful" methods, there is a need to inform parents and coaches of the risks and benefits of RWL.Diosmin (DIO) is a naturally occurring flavonoid with multiple beneficial effects on human health. The presence of different hydroxyl groups in diosmin structure enables its electrochemical investigation and quantification. This work presents, for the first time, diosmin voltammetric behavior and quantification on the cost-effective, disposable pencil graphite electrode (PGE). Diosmin oxidation on PGE involves two irreversible steps, generating products with reversible redox behaviors. All electrode processes are pH-dependent and predominantly adsorption-controlled. Differential pulse (DPV) and adsorptive stripping differential pulse (AdSDPV) voltammetric methods have been optimized for diosmin quantification o an H-type PGE, in 0.100 mol/L H2SO4. The linear ranges and limits of detection were for DPV 1.00 × 10-6-1.00 × 10-5 mol/L and 2.76 × 10-7 mol/L DIO for DPV and 1.00 × 10-7-2.50 × 10-6 mol/L and 7.42 × 10-8 mol/L DIO for AdSDPV, respectively. The DPV method was successfully applied for diosmin quantification in dietary supplement tablets. The percentage recovery was 99.87 ± 4.88%.The objective of this study was to identify phenotypic characteristics predicting the outcome of euthanasia for dogs entering shelters compared to live release. [https://www.selleckchem.com/products/Fludarabine(Fludara).html check details] Individual dog records for 2017 were requested from shelters in five states (Mississippi, Pennsylvania, Michigan, Colorado, and Oklahoma) receiving municipal funding and using electronic records. Duplicate dogs were removed and records from 17 shelters were merged into a dataset of 25,047 unique dogs with variables of breed, gender, coat color, size, age, region, and time in shelter. Only data from dogs with the potential to be adopted (n = 19,514) were analyzed. From these data, a simple random sample of 6200 dogs was used for modelling. Variables describing coat length, estimated adult size, and skull type were imputed from the breed description. A Cox proportional hazard model with a random effect of shelter was developed for the outcome of euthanasia using manual forward variable selection and significance for variable retention at alpha = 0.05. A size by geographic region interaction was associated with the hazard of euthanasia (p = 0.0204). Additionally, age group and skull type were both associated with euthanasia compared to live release (p less then 0.0001). The results of this study indicate that phenotypic characteristics of dogs are predictive of their hazard for euthanasia in shelters.Brassinosteroids (BRs) play a critical role in plant responses to stress. However, the interplay of BRs and reactive oxygen species signaling in cold stress responses remains unclear. Here, we demonstrate that a partial loss of function in the BR biosynthesis gene DWARF resulted in lower whilst overexpression of DWARF led to increased levels of C-REPEAT BINDING FACTOR (CBF) transcripts. Exposure to cold stress increased BR synthesis and led to an accumulation of brassinazole-resistant 1 (BZR1), a central component of BR signaling. Mutation of BZR1 compromised the cold- and BR-dependent increases in CBFs and RESPIRATORY BURST OXIDASE HOMOLOG 1(RBOH1) transcripts, as well as preventing hydrogen peroxide (H2O2) accumulation in the apoplast. Cold- and BR-induced BZR1 bound to the promoters of CBF1, CBF3 and RBOH1 and promoted their expression. Significantly, suppression of RBOH1 expression compromised cold- and BR-induced accumulation of BZR1 and related increases in CBF transcripts. Moreover, RBOH1-dependent H2O2 production regulated BZR1 accumulation and the levels of CBF transcripts by influencing glutathione homeostasis. Taken together, these results demonstrate that crosstalk between BZR1 and reactive oxygen species mediates cold- and BR-activated CBF expression, leading to cold tolerance in tomato (Solanum lycopersicum).Gastrointestinal (GI) cancer is a major cause of morbidity and mortality worldwide [...].Chronic oxidative stress (OS) can be an important factor of acute myeloid leukemia (AML) progression; however, there are no data on the extent/consequence of OS after transfusion of packed red blood cells (pRBCs) and platelet concentrates (PCs), which are commonly used in the treatment of leukemia-associated anemia and thrombocytopenia. We aimed to investigate the effects of pRBC/PC transfusion on the OS markers, i.e., thiol and carbonyl (CO) groups, 3-nitrotyrosine (3-NT), thiobarbituric acid reactive substances (TBARS), advanced glycation end products (AGE), total antioxidant capacity (TAC), SOD, GST, and LDH, in the blood plasma of AML patients, before and 24 h post-transfusion. In this exploratory study, 52 patients were examined, of which 27 were transfused with pRBCs and 25 with PCs. Age-matched healthy subjects were also enrolled as controls. Our results showed the oxidation of thiols, increased 3-NT, AGE levels, and decreased TAC in AML groups versus controls. After pRBC transfusion, CO groups, AGE, and 3-NT significantly increased (by approximately 30, 23, and 35%; p less then 0.