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our observation was evidence-based tumor specimen was microbiologically analysed.<br /><br />Our observation indicate significant role of commensal anaerobic bacteria in clinical history of cancer patient, opportunistic type of infectious process as well as therapeuthic prospect proliferative potential and anaerobic glycolysis of commensal Veillonella reduce access of cancer cells to nutrition's. It shed light on crucial role of innate immune response, acute phase reaction and neutrophils in immunotherapy outcome. Contrary to previous studies with statistical coexistence of several bacteria and cancer our observation was evidence-based tumor specimen was microbiologically analysed.A complex cardiac surgery may be associated with a number of complications. The occurrence of toxic epidermal necrolysis (TEN) in the postoperative period in a patient who has already experienced other complications contributes to the worsening of his prognosis. Despite the regression of necrotic skin lesions TEN can lead to tragic complications.<br /><br /> A 48-year-old patient was admitted as scheduled to a cardiac surgery ward for a complex cardiac surgery. During the procedure, a mechanical aortic valve prosthesis, an ascending aorta prosthesis were implanted, and the left internal thoracic artery (LIMA) was grafted to the left anterior descending coronary artery (LAD). The intraoperative course was not complicated. In the postoperative period, some fluid was found in the left pleural cavity, which was decompressed. In the following days of the postoperative period an instability of the sternum and a serous-bloody discharge from the wound ocurred, these resulted in the reoperation and use of vacuum-assisted closure (VAC) therapy. Later, there were also haemorrhagic complications requiring surgical intervention and numerous transfusions of blood components. The patient was diagnosed with a very rare complication in the form of toxic epidermal necrolysis. Despite the therapy and regression of skin lesions an irreversible multi-organ failure developed in the patient which resulted in his death.<br /><br /> Toxic epidermal necrolysis turned out to be a complication significantly contributing to the patient's death.<br /><br />Toxic epidermal necrolysis turned out to be a complication significantly contributing to the patient's death.Vitamin B12 deficiency anaemia in adults is usually caused by Addison- Biermer's disease. The presence of antibodies against gastric parietal cells and intrinsic factor (IF) in blood is typical for the disease. The gastrointestinal malabsorption or a diet poor in vitamin B12 are rarer causes. The disease manifests in hematological, neurological, psychiatric disorders and trophic changes of the tongue and oral mucosa, which leads to weight loss.<br /><br /> The authors describe a case of a 70-year-old woman with severe vitamin B12 deficiency based on chronic inflammatory lesions of the gastric mucosa caused by Helicobacter pylori infection. The patient had haematological (pancytopenia), neurological (problems with memory, concentration, numbness of the limbs, gait instability) and gastrological disorders (loss of appetite, weight loss). The laboratory and imaging diagnostics were performed. The neoplasmatic background was abandoned and pure vitamin B12 deficiency was diagnosed. All symptoms resolved completely after the supplementation and eradication of Helicobacter pylori.<br /><br /> The article demonstrates the problem of many severe, non- specific complications of vitamin B12 deficiency which requires extensive diagnostics and treatment. The similarity of symptoms may suggest a malignant disease especially in elderly patients.<br /><br />The article demonstrates the problem of many severe, non- specific complications of vitamin B12 deficiency which requires extensive diagnostics and treatment. The similarity of symptoms may suggest a malignant disease especially in elderly patients.Primary cardiac tumors are extremely uncommon but metastases can result from direct invasion from the mediastinum, hematogenous spread or extension of the tumor into the vena cava and the right atrium.<br /><br /> A 37-year-old male with no previous history of chronic diseases was admitted to the hospital due to non-specific chest discomfort, non-productive cough and weakness lasting for several weeks. Physical examination was unremarkable except for tachycardia and bibasal rales. Chest radiogram revealed multiple pulmonary lesions suggesting metastases. A mass in the right adrenal gland was found on abdominal ultrasound and CT scan. In addition, a pathological lesion in the inferior vena cava extending to the right atrium was detected. Echocardiography revealed a pedunculated mass measuring 2.3x1.5 cm, located in the right atrium, which originated from the inferior vena cava. During the diastole, it prolapsed to the right ventricle but did not significantly affect blood flow through the tricuspid valve. Adrenal tumor bncer directly extending from the inferior vena cava to the right atrium.Cardiovascular (CV) disease continues to be the main cause of morbidity and mortality in worldwide. Hyperhomocysteinemia (HHCy) is a novel metabolic risk factor of vascular damage. In addition to that, there is evidence that HHCy management with folic acid and vitamin B supplements prevents atherosclerosis and its sequelae. Oxidative stress is one of the mechanisms behind the cardiotoxic effects of high homocysteine levels. On the one hand, HHCy facilitates endothelial dysfunction, probably as a result of impaired synthesis and/or inactivation of nitrogen (II) oxide (NO). On the other hand, oxidation of homocysteine is accompanied by formation of reactive oxygen species (ROS), which induce lipid peroxidation in cell membranes and in low density lipoproteins, mitochondrial membrane, secretion of cytochrome C and activation of caspase-3, culminating in apoptosis. [https://www.selleckchem.com/products/XAV-939.html XAV-939] Thyroid hormones are known to have a profound effect on CV functions. Hyperthyroidism causes heart rate, myocardial contractility and ejection fractiomitochondrial membrane, which results in initiation of apoptotic cell death. The deficiency of thyroid hormones enhances initiation of programmed cell death.The number of cancer patients is growing in all countries. Due to the malignant progression of cancer, inflammatory processes are observed, which are inextricably linked with the response of the immune system.<br /><br /> The aim of this research was to study the effectiveness of the cytostatic Vincristine on the background of sorption correction of disorders by the carbon sorbent AUT-M (activated carbon tissue material) in adenocarcinoma of the colon.<br /><br /> To simulate carcinogenesis, 1,2-dimethylhydrazine (DMH) was administered subcutaneously to 76 rats for 30 weeks at a dose of 7.2 mg / kg body weight. The evolution of adenocarcinoma of the colon in experimental animals was confirmed by histological examination. After simulation of colon cancer, the animals were intragastrically administered entorosorbent at a dose of 1 ml of suspension (corresponding to 0.2 g of net weight of the drug) per 100 g of body weight of the animal, during 21 days. After detoxification therapy, rats with simulated carcinogenesis were administer Simultaneous use of enterosorption and cytostatic therapy helped to restore the cytokine balance and indicators of the humoral part of immunological protection.<br /><br />Simultaneous use of enterosorption and cytostatic therapy helped to restore the cytokine balance and indicators of the humoral part of immunological protection.Androgenetic alopecia is the most common type of hair loss both in male as well as female patients. It is a type of non-cicatricial hair loss. Pathophysiology of the disease remains largely unknown. It is believed that the occurrence of FPHL (female pattern hair loss) is linked with cellular insensitivity to androgens. Human hair does not only represent beauty, health and youth, but it also has a significant impact on one's self-esteem. For many patients, hair loss is a stigmatizing experience, many of them complain about a lower quality of life, anxiety or even depression.<br /><br /> Aim of the study was to evaluate the levels of selected clinical parameters, including exposure to stress and disease progression based on the Ludwig scale, and of the applied therapies in a group of female patients with androgenetic alopecia.<br /><br /> A group of 106 patients with androgenetic alopecia was analyzed with respect to their age, duration of disease, disease progression based on the Ludwig scale, family history of AGA, exposure to stf them used dietary supplements or OTC topical agents.<br /><br /> High levels of stress exposure reported by patients most probably stemmed from the symptoms of the disease itself, as the study population was quite diverse in terms of their levels of professional activity and the type of profession performed.<br /><br />High levels of stress exposure reported by patients most probably stemmed from the symptoms of the disease itself, as the study population was quite diverse in terms of their levels of professional activity and the type of profession performed.Medical sponge is a tool that has absorbent and antiseptic properties, as well as stimulates tissue regeneration and is used in surgery, neurosurgery, dentistry, otolaryngology and gynecology to stop blood loss or to close wound surfaces (burns, trophic ulcers). To summarize the information of the professional literature on medical (hemostatic) sponges, their classification and applications, the areas of their use in medical practice and also modern excipients and active pharmaceutical ingredients that can be used in their technology.<br /><br /> The aim of the study was to summarize data on the characteristics, classification of medical sponges, auxiliary substances and active pharmaceutical ingredients used in the technology of these agents and medical use.<br /><br /> Methods of information retrieval, analysis of statistics and scientific literature on medical sponges and prospects of their use were applied in the study.<br /><br /> Despite the creation and research of a large number of medical sponges based on gelatin, chitosan, cellulose derivatives, collagen and other excipients, as well as the clinical demonstration of their efficacy and need for use, medical sponges are still need refinement and further study. Because of it, the search for the perfect foundation to create universal medical sponge is still ongoing.<br /><br /> Expanding the range of medical sponges and researching new excipients for their manufacture are a promising area of modern medicine and pharmacy.<br /><br />Expanding the range of medical sponges and researching new excipients for their manufacture are a promising area of modern medicine and pharmacy.Sagittal balance of operated cervical spine has a great influence on the intensity of pain syndrome, the overall quality of life, the speed and quality of consolidation, and the rate of progression of adjacent segment degeneration.<br /><br /> The aim of this study was to determine the correlation of the local segmental and the total sagittal alignment of cervical spine when performing anterior cervical corpectomy and fusion (ACCF) using different vertebral body replacement systems.<br /><br /> A retrospective analysis of late postoperative radiographs of 260 patients, who underwent ACCF due to subaxial traumatic injury of the cervical spine, was performed. Total cervical lordosis (TCL) and operated segment lordosis (OSL) were measured. Patients were divided into 2 groups depending on type of fusion system (first group mesh + ventral plate, second telescopic implant).<br /><br /> The average TCL value in patients of the first group was 14.52o (95% CI 11.75o; 17.29o), while in the second group it was 21.58o (95% CI 19.58o; 23.58o), with the range of values being significantly wider in the first group (- 3.