Zobrazení zdroje stránky Martinussenlundsgaard5407

This study aimed to develop a digitised Mandarin Nonsense Word Speech Perception Test for use in Malaysia, a multilingual country in Southeast Asia.<br /><br /> In Phase I, 400 vowel-consonant-vowel (VCV) nonsense word samples containing 20 Mandarin consonants in /a/, /i/, or /u/ contexts were recorded from two speakers of different genders. Acoustic analyses, sound quality ratings, and item validations were used to guide selection of items to form two gender-specific test lists. In Phase II, performance-intensity functions and test-retest reliability for the lists were established.<br /><br /> Native Mandarin-speaking adults with normal hearing participated in Phase I (n = 10) and Phase II (n = 69).<br /><br /> Eighty-four of the 400 VCV words were selected to form two gender-specific test lists. A two-way repeated measure ANOVA revealed a significant interaction effect between speaker-gender and presentation level [F (4.88, 283.20) = 22.79, p &lt; 0.001, η<br /><br /> <br /><br /> = 0.28]. Intraclass correlation scores of 0.75 and 0.87 were obtained for the female-speaker and male-speaker lists respectively.<br /><br /> The preliminary normative data of the Mandarin nonsense word test have been developed. It is recommended to use separate gender-specific norms when conducting the test. The test has good validity and reliability for testing Mandarin-speaking adults in Malaysia.<br /><br />The preliminary normative data of the Mandarin nonsense word test have been developed. It is recommended to use separate gender-specific norms when conducting the test. The test has good validity and reliability for testing Mandarin-speaking adults in Malaysia.Background Repetitive transcranial magnetic stimulation (rTMS) shows potential therapeutic effects for individuals with addiction, but few studies have examined individuals with opioid use disorder (OUD).Objectives We conducted an add-on double-blinded, sham-controlled rTMS feasibility pilot trial to examine OUD participants undergoing methadone maintenance therapy (MMT). The current report focused on the effects of rTMS on (1) craving and heroin use behavior and (2) depression, impulsivity, and attention.Methods Active or sham rTMS treatment was applied to the left dorsolateral prefrontal cortex (DLPFC) over a total of 11 sessions in 4 weeks (15-Hz frequency, 4 seconds per train, intertrain interval of 26 seconds, 40 trains per session) in OUD participants (ClinicalTrials.gov registration number NCT03229642). Craving, heroin use severity, urine morphine tests, the Hamilton Depression Rating Scale (HDRS), the Barratt Impulsiveness Scale-11 (BIS-11), and the Continuous Performance Tests (CPTs) were measured.Results Twenty-two OUD participants were enrolled, of which eleven (8 males) were undergoing active rTMS and nine (8 males) were in the sham rTMS group. After 12 weeks of follow-up, the active rTMS group did not show significantly greater improvements than the sham group with respect to craving, heroin use, or urine morphine test results. However, HDRS scores, BIS-11 attentional subscales, and CPTs commission T-scores (C-TS) were significantly lower in the active rTMS group (P = .003, 0.04, and 0.02, respectively) than in the sham group.Conclusion Add-on rTMS did not appear to improve heroin use behavior but may have benefitted depressive symptoms, impulse control and attention in OUD participants undergoing MMT.Health research has begun to pay increasing attention to inactivity in its broadest sense as lack of meaningful activity and boredom. Few studies however have taken a critical look at this phenomenon. We explore (in)activity drawing on ethnographic data from observations in an acute stroke unit and post-discharge interviews with stroke survivors and their families. Four themes emerged that explain patients' (in)activity (i) planned activities; (ii) 'doing nothing', (iii) the material environment of the unit; (iv) interactions with staff. [https://www.selleckchem.com/products/plx5622.html learn more] Considering these themes, we seek to problematise received conceptual and methodological approaches to understanding (in)activity. We argue that (in)activity is best conceived not as lack of action or meaning, but as a situated practice encompassing both bodily and mental activities that reflect and reproduce the way in which life is collectively organised within a specific healthcare setting.Background Brain structural findings in chronic methamphetamine users have been inconsistent. Identifying contributing influences (e.g., sex, abstinence duration) can help clarify the clinical course of recovery.Objectives We studied the effects of long-term methamphetamine abstinence on gray-matter volume. Our hypothesis was that smaller volume early in abstinence would precede long-term recovery.Methods Individuals who used methamphetamine (≥100 g lifetime use, mandated to residential treatment for methamphetamine-positive urine; 40 men, 21 women), undergoing supervised abstinence (men 12-400 days; women 130-594 days), were compared to healthy controls (49 men, 36 women) using T1-weighted MRI. Volumes of orbitofrontal, anterior cingulate and parietal cortex, hippocampus, and striatum were measured using Freesurfer software. Associations of volumes with abstinence duration were tested in males and females separately because their abstinence times differed (121.5 ± 124.5 vs. 348.0 ± 128.6 days, p less then 0.001); only males were studied in early abstinence. The General Linear Model was used to test effects of abstinence duration and group (methamphetamine users vs. controls).Results In males, duration of abstinence was multivariate significant for gray-matter volumes (p = 0.017). Abstinence duration was associated with increases in volumes of the orbitofrontal and parietal cortices (ps = 0.031, 0.016) and hippocampi (ps = 0.044). Irrespective of abstinence, male methamphetamine users had smaller hippocampi than male controls (p = 0.008). Females showed no significant effects of group or abstinence.Conclusions In males, abstinence from methamphetamine appears to result in volumetric increases in regions important for cognitive function, which may affect recovery during the course of treatment. Data from the period of early abstinence are required to evaluate volumetric changes in females.