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The causes of medical personnel dissatisfaction with professional work are closely related to causes of under-exploitation of their professional and personal potential. The main factors diminishing satisfaction of medical personnel with professional labor are low wages at significant workload. The system of organizational measures to optimize application of existing manpower in medical organizations is proposed. The strategic reserve of increasing efficiency of medical organization functioning is realization of need of medical personnel in effective application and development of their professional and personal potential.The article considers problematic issues in hospital-replacing out-patient mental care management on the basis of the Psychiatric Hospital № 13 in 2015-2017. The analysis covered structure of mental patients, their age and social status. Also, patients under active dispensary monitoring and compulsory continuous out-patient treatment were analyzed. The new management component - «the out-patient psychiatric module» - is proposed to be introduced into the structure of mental dispensary.In modern conditions, the support of quality of medical care is one of key issues in health care management. Therefore, quality control issues are most important ones. The effective tool for monitoring quality of medical care is the medical care quality expertise. Hence, the legal regulation of this type of activity acquires special relevance. The article considers absence of uniform approaches to medical care quality expertise that does not allow to apply comparative analysis to processes of medical care support in medical organizations of various affiliations and to monitor both medical care quality and prevalence of medical errors to implement strategy of ensuring medical care quality. The identified legal aspects determine the need for further improvement of normative legal regulation of medical care quality expertise, specifying its role in the system of quality control and safety of medical care, unification of corresponding approaches, regardless of type of financing of medical care, departmental or territorial affiliation.The article presents results of measures of increasing research potential of participants of the scientific and educational medical cluster «North Caucasian». The measures include both organizational measures and measures of meaningful nature, i.e. union of scientific and pedagogical workers in scientific areas and their inclusion into activities of scientific schools. The steps are undertaken within the framework of scientific and educational cluster resulted in an increasing of scope of research work and incomes received from their commercialization. The integration of medical universities and medical institutes and departments of classical universities under the Ministry of Education and Science gives synergistic effect in development of innovative products.The ultrasound studies are highly informative diagnostic methods. The modern ultrasound devices can be applied as component of mobile telemedicine systems that can significantly increase availability of medical care. However, application of ultrasound scanners requires inclusion of ultrasound diagnostics specialist in the medical team that is not always nor possible or appropriate. [https://www.selleckchem.com/products/xst-14.html XST-14] In the modern regulatory legal base, transfer of certain functions of ultrasound diagnostics specialist to average medical staff is not provided. The article considers issue of genuine development and testing method of implementation of ultrasound examinations by paramedical personnel under remote control of physician. Two organizational models were tested within the framework of organizational experiment. In the first model, physician monitored progress of examination by telemedicine monitor and, if necessary, directed actions of medical nurse. In the second model, the nurse independently obtained images of patients' organs, and physician according received visual information formulated final conclusion. The organizational experiment included patients with pathology of abdominal cavity, retroperitoneal space and lower limb arteries. Results. On the basis on results of 156 examinations, time-consuming analysis was performed, and effectiveness of developed methods was evaluated. The proposals were proposed to include additions into professional standard of ultrasound diagnostics nurse and to substantiate the need of altering the training programs for paramedical personnel.The term "regulatory guillotine" means analysis of all existing normative legal acts in order to understand their compliance with modern requirements. If these regulations meet the requirements, then the rules remain; if not, they must either be canceled and new regulation to be elaborated or corresponding changes must be implemented to current regulation. To resolve this problem, the government of the Russian Federation decided to implement the "regulatory guillotine" procedure. The main task of this procedure is to completely replace the entire array of norms that establish mandatory requirements with new ones by January 1, 2021. This will reduce administrative burden on business and increase level of security for consumers of various services. The same work is applied to the standards regulating management of quality and safety of medical activities. The article analyzes normative legal acts that regulate quality and safety management of medical activities, as well as new normative legal acts that are already accepted but still are not entered into force.To ensure financial stability of state medical organization in actual conditions requires focused consideration of various aspects of implementation of paid medical services in national health care. The analysis of publications demonstrated that experience of variety of models for providing paid medical care in state medical organizations and new directions of improving efficiency, availability and quality of medical services are mainly considered. The specificity of medical activity is conditioned by consumer-oriented activities because of direct relationship to life and health of patients. The success of medical marketing depends on achievement of loyalty of consumers of medical services. It is particularly important to ensure compliance with principle of patient-oriented organization of paid medical services. The article considers practical implementation of patient-orientated principle in paid medical services in state medical organization. The article presents elaborated and implemented set of scientifically based measures for main directions of medical activity.