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In this work, we employ the extension of Mawhin's coincidence degree by Ge and Ren to investigate the solvability of the p-Laplacian higher-order boundary value problems of the form ( w ( t ) ϕ p ( x ( n - 1 ) ( t ) ) ) ' = h ( t , x ( t ) , ⋯ , x ( n - 1 ) ( t ) ) , 0 0 for all t ≥ 0 , ϕ p s = | s | p - 2 s .<br /><br /> Genistein is an isoflavone compound that has been proven to have anticancer activity and is capable of binding to estrogen β receptors with Selective Estrogen Receptor Modulators (SERMs) properties, and has a strong affinity to inhibit the development of cancer cells. This study is to determine the optimum conditions of the reaction in the synthesis process of compounds labeled <br /><br /> I-genestein which can be potential for application of breast cancer diagnosis.<br /><br /> Synthesis of <br /><br /> I-Genistein compound labeling using the Chloramine-T iodination method. This method uses several parameter optimizations, including pH conditions, the amount of chloramine-T oxidizer and sodium metabisulfite reducing agent. The radiochemical purity of the <br /><br /> I-Genistein compound was determined using thin layer chromatography TLC-SG F<br /><br /> , and measured by SCA (Single Channel Analyzer). The radiochemical purity of labeled compounds must fulfill the requirements of the United States of Pharmacopeia.<br /><br /> Optimization of the synthesis conditions of the <br /><br /> I-Genistein compound was obtained at pH 8, the amount of chloramine-T 0.225 mg, and the amount of Na-Metabisulfite 0.342 mg, with 30 min reaction time. [https://www.selleckchem.com/products/sy-5609.html SY-5609 inhibitor] This optimum condition produces radiochemical purity of 95.02 ± 0.76%.<br /><br /> Products labeled <br /><br /> I-Genistein meet radiochemical purity requirements according to USP requirements. The labeled compound is expected to be able to be used to detect breast cancer through a binding mechanism with estrogen receptors β.<br /><br />Products labeled 131I-Genistein meet radiochemical purity requirements according to USP requirements. The labeled compound is expected to be able to be used to detect breast cancer through a binding mechanism with estrogen receptors β.<br /><br /> Malaria in pregnancy is a major public health problem in Nigeria. Long-Lasting Insecticidal Nets (LLINs) have been advocated as an effective tool against malaria transmission. However, success of this intervention largely depends on the knowledge and practices regarding malaria and its prevention. Unfortunately, few studies have been done on effect of malaria preventive education on use of LLIN in pregnancy.<br /><br /> To assess the knowledge of malaria and determine the effect of malaria preventive education on the use of LLINs among pregnant females in a Teaching Hospital in Osun state.<br /><br /> It was a one group pre-test post-test quasi - experimental hospital based study involving pregnant females attending Ante-Natal Clinic (ANC) of the Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC). A total of 200 respondents were recruited for this study by 2-stage sampling technique. Data was collected using a pretested questionnaire to elicit information on socio-demographic characteristics, use of LLIN in pregnanedictors of LLINs use. Biserial correlation showed a statistically positive relationship between knowledge of malaria preventive education and use of LLINs after intervention (<br /><br /> =0.036, <br /><br /> &lt;0.01).<br /><br /> The use of malaria preventive education was found to be effective in increasing the use of LLIN in this study. These findings highlight a need for educational intervention in implementation of LLINs. There is therefore a need to strengthen the policy of malaria prevention education as an integral component with distribution of free LLIN in health care setting to enhance its utilization.<br /><br />The use of malaria preventive education was found to be effective in increasing the use of LLIN in this study. These findings highlight a need for educational intervention in implementation of LLINs. There is therefore a need to strengthen the policy of malaria prevention education as an integral component with distribution of free LLIN in health care setting to enhance its utilization.In the Trans-Pecos region of Texas, reports of domestic triatomine bites were common (67%), with 36% of residentially collected triatomines positive for Trypanosoma cruzi. Despite the transmission potential, no human infections were detected. Collected Triatoma rubida species were themselves frequently parasitized with mites.This study was conducted to evaluate the alleviation of Bacillus subtilis ANSB01G culture as zearalenone (ZEA) biodegradation agent on oxidative stress, cell apoptosis and fecal ZEA residue in the first parity gestation sows during the gestation. A total of 80 first-parity gilts (Yorkshire × Landrace) were randomly allocated to 4 dietary treatments with 20 replications per treatment and one gilt per replicate. The dietary treatments were as follows CO (positive control); MO (negative control, ZEA level at 246 μg/kg diet); COA (CO + B. subtilis ANSB01G culture with 2 × 109 CFU/kg diet); MOA (MO + ZEA level at 260 μg/kg diet + B. subtilis ANSB01G culture with 2 × 109 CFU/kg diet). The experiment lasted for the whole gestation period of sows. Results showed that feeding the diet naturally contaminated with low-dose ZEA caused an increase of cell apoptosis in organ and the residual ZEA in feces as well as a decrease of antioxidant function in serum. The addition of B. subtilis ANSB01G culture in the diets can effectively alleviate the status of oxidative stress and cell apoptosis induced by ZEA in diets of gestation sows, as well as decrease the content of residual ZEA in feces.Diarrhea is considered to be associated with microbial dysbiosis caused by infection of pathogens but poorly understood. We herein characterized the colonic microbiota of diarrheal early-weaning piglets infected with porcine circovirus type 2 (PCV2) and Campylobacter. Campylobacter infection significantly decreased species richness and Shannon diversity index of colonic microbiota together with a significant increase in the proportion of Campylobacter and Enterobacteriaceae, whereas no significant difference on the above indexes was observed in piglets infected with PCV2 compared with healthy piglets. PCV2 and Campylobacter infection could disturb the homeostasis of colonic microbiota through deterioration of ecological network within microbial community, and specially Campylobacter performed as a module hub in ecological networks. The microbial dysbiosis caused metabolic dysfunction and led to a remarkable reduction in production of short chain fatty acids, following by a higher pH level in colon cavity. Campylobacter infection disturbed the function of colonic tract barrier observed in terms of significant lower relative expression of claudin-1, occluding, and zonula occludens protein-1 genes, and PCV2 infection induced intestinal inflammation together with a higher permeability of colon.