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Among girls, dose-response positive association was found between duration of mobile devices usage and total difficulty score (P for trend &lt;0.001).<br /><br /> Among children aged 9-10 years old, mobile devices usage time of less than 1 h was a protective factor for behavior problems in boys, while usage time of 1-h or more was a risk factor in girls. Further longitudinal study is warranted to confirm the findings.<br /><br />Among children aged 9-10 years old, mobile devices usage time of less than 1 h was a protective factor for behavior problems in boys, while usage time of 1-h or more was a risk factor in girls. Further longitudinal study is warranted to confirm the findings.<br /><br /> To improve pediatric airway management outside of the operating room, a Hospital-wide Emergency Airway Response Team (HEART) program composed of anesthesiology, otorhinolaryngology, and respiratory therapy clinicians was developed.<br /><br /> To report processes and outcomes of HEART activations in a quaternary academic children's hospital.<br /><br /> A retrospective observational cohort study between January 2017 and December 2019. Local airway emergency database was reviewed for HEART activations. Additional safety data was obtained from patients' electronic health records.<br /><br /> Adverse airway outcomes, either adverse tracheal intubation-associated events or oxygen desaturation (SpO<br /><br /> &lt;80%). We compared airway management by primary teams before HEART arrival and by HEART after arrival.<br /><br /> Of 96 HEART activations, 36 were from neonatal intensive care unit, 35 from pediatric and cardiac intensive care units, 14 from emergency department, and 11 from inpatient wards. 56 (62%) children had airway anomalies and 41/96 (43%) were operating room. Adverse airway outcomes were more frequent before compared to after HEART arrival.<br /><br />A multidisciplinary emergency airway response team plays an important role in pediatric airway management outside of the operating room. Adverse airway outcomes were more frequent before compared to after HEART arrival.<br /><br /> Kinetic estimated Glomerular Filtration Rate (KeGFR) approximates GFR under non-steady-state conditions. We investigated whether the ratio of KeGFR difference to baseline eGFR could predict acute kidney injury (AKI) earlier than a creatinine-based algorithm that triggered an AKI electronic Alert (eAlert).<br /><br /> This retrospective, single-centre, proof-of-concept cohort study assessed all patients diagnosed with AKI by an automated serum creatinine-based eAlert. The kinetic eGFR, the kinetic eGFR difference from baseline and the ratio of difference to baseline was calculated in subjects with at least two serum creatinine (sCr) measurements within 72 h of AKI.<br /><br /> Patients in the AKI cohort (n=140) had a significant decline in KeGFR ratio (AKI 17% IQR 7% to 29%, Non-AKI 0 IQR -12% to 9%; P-value &lt;.0001). A decrease of the ratio greater than 10% predicted AKI with a sensitivity of 66%, a specificity of 77%, a positive predictive value of 63%, and negative predictive value of 80%. The median lead time between KeGFR ratio decrease and AKI was 24 h (IQR 19-27 h).<br /><br /> KeGFR ratio is a cheap, simple method that predicted AKI 24 h before laboratory detection. KeGFR may facilitate triaging patients to increased monitoring or intervention.<br /><br />KeGFR ratio is a cheap, simple method that predicted AKI 24 h before laboratory detection. KeGFR may facilitate triaging patients to increased monitoring or intervention.<br /><br /> We aimed to determine the effects of conscious and deep sedation on vagal response (VR) characteristics during ganglionated plexus (GP) ablation.<br /><br /> Forty consecutive patients undergoing GP ablation for vasovagal syncope were divided to receive conscious sedation with midazolam (Group 1, n = 29) or deep sedation with the midazolam-propofol combination (Group 2, n = 11). VR was defined on three levels. R-R interval increase of &gt;50% (Level 1); R-R interval increase of 20%-50% (Level 2); and R-R interval increase of &lt;20% (Level 3).<br /><br /> The ratio of Level 1 VR during ablation on left superior and inferior GPs was significantly lower in Group 2 (p &lt; .0001 and p = .034, respectively). Once the cut-off for VR was decreased to Level 2, the ratio of (+) VR was similar between groups during ablation of left-sided GPs. Positive VR in any level was lower than 20% during ablation of right-sided GPs.<br /><br /> The autonomic tone might be affected in different ways by the level or type of intravenous sedation. Awareness of anesthesia-related differences may be important if GP ablation will be performed by using VR characteristics during ablation.<br /><br />The autonomic tone might be affected in different ways by the level or type of intravenous sedation. Awareness of anesthesia-related differences may be important if GP ablation will be performed by using VR characteristics during ablation.Large vertebrates are extremely sensitive to anthropogenic pressure, and their populations are declining fast. The white rhinoceros (Ceratotherium simum) is a paradigmatic case this African megaherbivore has suffered a remarkable decline in the last 150 years due to human activities. [https://www.selleckchem.com/products/wnt-agonist-1.html Wnt agonist 1] Its subspecies, the northern (NWR) and the southern white rhinoceros (SWR), however, underwent opposite fates the NWR vanished quickly, while the SWR recovered after the severe decline. Such demographic events are predicted to have an erosive effect at the genomic level, linked to the extirpation of diversity, and increased genetic drift and inbreeding. However, there is little empirical data available to directly reconstruct the subtleties of such processes in light of distinct demographic histories. Therefore, we generated a whole-genome, temporal data set consisting of 52 resequenced white rhinoceros genomes, representing both subspecies at two time windows before and during/after the bottleneck. Our data reveal previously unknown population structure within both subspecies, as well as quantifiable genomic erosion. Genome-wide heterozygosity decreased significantly by 10% in the NWR and 36% in the SWR, and inbreeding coefficients rose significantly by 11% and 39%, respectively. Despite the remarkable loss of genomic diversity and recent inbreeding it suffered, the only surviving subspecies, the SWR, does not show a significant accumulation of genetic load compared to its historical counterpart. Our data provide empirical support for predictions about the genomic consequences of shrinking populations, and our findings have the potential to inform the conservation efforts of the remaining white rhinoceroses.