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To correlate uterine artery Doppler findings with maternal and neonatal outcomes in early- and late-onset preeclampsia with severe features.<br /><br /> Doppler scan was done in both uterine arteries. Maternal and neonatal outcomes in women with abnormal and normal Doppler results were compared.<br /><br /> Abnormal Doppler results were present in 45 women (75%). Thirty-four (56.7%) women had abnormal RI, 19 (31.6%) had abnormal PI, and 36 (60%) had diastolic notch. Of the women who participated in the study, 21.6% developed maternal complications, and the majority belonged to the early-onset severe preeclampsia group. Diastolic notch was twofold more frequent in the early group. RI was abnormal in 63% of the early-onset and 50% of the late-onset group.<br /><br /> Pregnancies with early-onset preeclampsia who had abnormal uterine artery Doppler findings were at high risk for both maternal and neonatal complications, whereas those who had late-onset preeclampsia with abnormal Doppler findings only had an increased risk of perinatal complications.<br /><br />Pregnancies with early-onset preeclampsia who had abnormal uterine artery Doppler findings were at high risk for both maternal and neonatal complications, whereas those who had late-onset preeclampsia with abnormal Doppler findings only had an increased risk of perinatal complications.<br /><br /> The PrismRA<br /><br /> test identifies rheumatoid arthritis (RA) patients who are unlikely to respond to anti-tumor necrosis factor (anti-TNF) therapies. This study evaluated the clinical and financial outcomes of incorporating PrismRA into routine clinical care of RA patients.<br /><br /> A decision-analytic model was created to evaluate clinical and economic outcomes in the 12-month period following first biologic treatment. Two treatment strategies were compared (1) observed clinical decision-making based on a 175-patient cohort receiving an anti-TNF therapy as their first biologic after failure of conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and (2) modeled clinical decision-making of the same population using PrismRA results to inform first-line biologic treatment choice. Modeled costs include biologic drug pharmacy, non-biologic pharmacy, and total medical costs. The odds of inadequate response to anti-TNF therapies and various components of patient care were calculated based on PrismRA resultve an inadequate response to anti-TNF therapies could save &gt; $7 million in overall ineffective healthcare costs per 1000 patients tested and increase targeted DMARD response rates in RA.<br /><br /> $7 million in overall ineffective healthcare costs per 1000 patients tested and increase targeted DMARD response rates in RA.In recent years the involvement of technology in psychiatric treatment and its usefulness is increasing. The main advantages of its use lie in the possibility of collecting passively data with greater temporal granularity from each patient individually, since these devices are in direct contact almost every minute of the day with them. The variety of data collected by the all the smartphone sensors allows for a better understanding of the patient behavior through what is called the digital phenotype. So the use of a continuous monitoring system for patients at risk of suicide becomes a very useful tool for improving the quality of life of patients and for the early detection of suicide attempts.Until now, rare earth elements (REEs) recycled from the green phosphor of waste fluorescent lamps (FLs), essentially terbium, remain a major challenge. The sulfuric acid effect on leaching efficiency of REEs from phosphor powder (PP) is investigated in this paper. According to a composite central design, experimental leaching study is performed under various parameters (acid concentration, leaching temperature, and time as well as liquid-to-solid ratio (L/S)). A statistical model of experiments and an analysis of variance are studied in order to predict leaching process. The results showed that by decreasing concentration and L/S ratio while increasing leaching time at optimal temperature value permits profitable terbium extraction. Afterwards, the developed statistical model is explored for an optimized response surface methodology. The obtained results were tested experimentally and showed best terbium extraction with 75%. Moreover, 0.01% for the major contaminant, that is calcium, is reached. This low calcium yield may have a further advantage during REE recovery in the downstream. Therefore, resulting solution under optimal conditions is treated with oxalic acid followed by a calcination of the solid precipitate. Finally, 43.57% and 49.38% are produced for terbium and yttrium oxides, respectively.Dissolved organic matter (DOM) controls the fate of a variety of nutrients and trace metals in river estuary systems. The aim of our study is to explore the sources, structure characteristics of sediment DOM, and potential ecological release risk (heavy metal, N and P) under the environmental conditions of Dagu River estuary. The relative contribution of DOM source was calculated by carbon stable isotope (combining δ13CDOM and C/N ratios). The structural characteristics of sediment DOM in Dagu River estuary were determined by ultraviolet-visible spectroscopy (UV-vis) absorbance and fluorescence spectroscopy. The potential ecological risks of heavy metals and N and P release were also assessed. Results show that the relative contributions of rural area and aquaculture are high in Dagu River estuary. The humification degree of DOM in downstream river is higher than that in the estuary, and the sediment DOM in Dagu River estuary is influenced by both terrestrial input and biological metabolism. The potential risk of eutrophication in the estuary is high. Moreover, under the effect of aquaculture and rural area, there is higher potential ecological release risk of heavy metal in the estuary. And samples in the middle transect have the highest potential ecological risks of heavy metal. [https://www.selleckchem.com/products/pexidartinib-plx3397.html PLX3397 cell line] Therefore, a framework has been proposed to predict the ecological status of the estuary by analyzing the sources, content, and structural characteristics of sediment DOM. These results provide a new insight on ecological indication of DOM in Dagu River estuary.