Zobrazení zdroje stránky Kjeldsenmorris9708

Aim To develop nomograms for predicting cancer-specific survival (CSS) and overall survival (OS) in patients with invasive extramammary Paget's disease (iEMPD). Patients &amp; methods Retrospective data of 1955 patients with iEMPD were collected from the Surveillance, Epidemiology, and End Results database. Nomograms for predicting CSS and OS were established using competing risk regression and Cox regression, respectively, and were internally validated. Results Five (age, surgery, tumor location, stage and concurrent malignancy) and eight (gender, age, race, marital status, surgery, tumor location, stage and lymph node metastasis) clinicopathological factors were utilized to construct nomograms for predicting CSS and OS, respectively. [https://www.selleckchem.com/products/ide397-gsk-4362676.html GSK-4362676 cost] The concordance indices of the nomograms for predicting CSS and OS were 0.78 and 0.73, respectively. The validation of the nomograms showed good calibration and discrimination. The decision curve analyses confirmed the clinical utility of these nomograms. Conclusion The nomograms can be a reliable tool for treatment design and prognostic evaluation of iEMPD.Background Platelets are important in the pathogenesis of myocardial infarction (MI). We hypothesize that patients with acquired thrombocytopenia such as idiopathic thrombocytopenic purpura (ITP) may have lower MI rate. Materials &amp; method The Nationwide Inpatient Sample was used for this study. We analyzed the correlation between ST-elevation MI (STEMI) and ITP utilizing ICD-9 codes. Results STEMI rate was lower in patients with ITP. We found that, in 2002, STEMI occurred in 0.64% of patients with ITP versus 0.89 (p less then 0.007) and for 2011 0.30 versus 0.48 (p less then 0.005). After adjusting for tobacco use, diabetes, hypertension, hyperlipidemia, gender and age, STEMI rate remained lower in ITP patients. Conclusion ITP appears to be associated with lower STEMI rate suggesting low platelet count may exert protective effect from STEMI.A facile photocatalyzed strategy for difunctionalization of styrenes in the presence of CS2 and amines providing β-keto dithiocarbamates has been developed. In the case of 4-nitrostyrene and 2-vinylpyridine, however, only 2-arylethylthiocarbamates are interestingly formed without the aid of photoredox catalysis/TBHP.The conjugated π-system in polyenes can be interrupted by electrocyclic ring-closure reactions. In this work, this 6π-electrocylization is shown by means of density functional calculations to be reversible by the application of an external mechanical pulling force at the terminal ends of the interrupted polyene chain. The test systems were constrained in a fused ring system, thus locking the orientation of three π-bonds and generally promoting 6π-electrocyclic ring-closure reactions. For several systems, the forward reaction is exergonic and the corresponding reaction barrier is comparable to those reported in the literature. The reverse reaction is triggered by an external pulling force of 2 nN (nano-Newton) or less and also becomes exergonic in all investigated polyenes under these force conditions. Moreover, it proceeds via a low reaction barrier when a pulling force of 2 nN is active, indicating that the mechanical force is an efficient stimulus for triggering ring-opening reactions. Analysis of the strain energy induced by this mechanical force confirms an optimal activation of the corresponding C-C σ-bond that breaks upon ring opening when the pulling positions are located on the polyene chain.The practical applications for the distinctive functions of metamagnetic Heusler alloys, such as magnetic shape memory effect, various caloric effects, etc., strongly depend on the phase transition temperatures. Here, flexible Heusler alloy Ni-Mn-Sn films have been deposited on mica substrates by pulsed laser deposition with a Ti buffer layer. Clear ferromagnetic (FM) transition followed by the martensitic transformation at around room temperature and exchange bias (EB) with a blocking temperature of 70 K are observed. Under the application of both tensile and compressive strains by bending the mica substrates, all the characteristic temperatures of Ni-Mn-Sn films, including the FM transition temperature, martensitic transformation temperature, and blocking temperature of EB, are significantly increased by about 10 K. Furthermore, EB field and coercivity are both strongly strengthened, which is mainly caused by the simultaneous enhancement of FM and anti-FM Mn-Mn coupling because of their shortened separations by strain and verified by the Monte Carlo simulation results. The strain controlling for structural and magnetic properties provides efficient manipulation for Heusler alloy-based magnetic devices.Colloidal crystals develop structural colors through wavelength-selective diffraction. Recently, a granular format of colloidal crystals has emerged as building blocks to construct macroscopic photonic surfaces or architectures with high reconfigurability through the secondary assembly. Here, we design elastic photonic microcapsules containing colloidal crystallites along the inner wall as a building block. Water-in-oil-in-water double-emulsion templates are microfluidically prepared to have an aqueous dispersion of polystyrene particles in the inner droplet and polydimethylsiloxane prepolymers in the shell. Colloidal particles are enriched in the presence of depletant and salt by osmotic compression, with the crystallization at the inner interface by depletion attraction. The number of nucleation sites depends on the rate of the enrichment, which enables control over the size and surface coverage of the crystallites with osmotic conditions. The enrichment is ceased by transferring the droplets into an isotonic solution, and the oil shell is cured to form an elastic membrane. As the elastic microcapsules have a large void in the core, they are deformable without structural damage in the crystallites. Therefore, the microcapsules can be closely packed to form macroscopic surfaces while achieving a high quality of structural colors with a collection of crystallites aligned along the flattened membrane.