Zobrazení zdroje stránky Kirkebyallred2202

Lipomas are benign soft tissue neoplasms of mature adipose tissue commonly occurring in the trunk or extremities. But, intraoral lipomas are rare entities which may be only noticed during routine dental examinations. Especially intramuscular lipomas on the tongue have been reported very rarely. In this study, we report a case of intramuscular lipoma on tongue, with a review of the literature from 1978 to 2019, providing data on age, gender, location, presenting symptoms, size, surgical methods, and recurrence.<br /><br /> A case of intramuscular lipoma occurring in tongue region in a 65-year-old male is reported. Surgical excision is the mainstay of treatment for the lesion. In order to decrease the deformity and discomfort after the excision, we tried to modify surgical technique using enveloped mucosal flap. This technique provided more comfortable healing procedure on the operative site without recurrence.<br /><br /> This is a rare case of large intramuscular lipoma on tongue. Surgical excision with enveloped mucosal flap design was performed to diminish postoperative raw surface and discomfort and a 24-month follow-up showed excellent healing without any recurrence. A case of intramuscular lipoma on tongue and relevant literature reviews are presented in this study.<br /><br />This is a rare case of large intramuscular lipoma on tongue. Surgical excision with enveloped mucosal flap design was performed to diminish postoperative raw surface and discomfort and a 24-month follow-up showed excellent healing without any recurrence. A case of intramuscular lipoma on tongue and relevant literature reviews are presented in this study.<br /><br /> Trialing novel cancer therapies in the clinic would benefit from imaging agents that can detect early evidence of treatment response. The timing, extent and distribution of cell death in tumors following treatment can give an indication of outcome. We describe here an <br /><br /> F-labeled derivative of a phosphatidylserine-binding protein, the C2A domain of Synaptotagmin-I (C2Am), for imaging tumor cell death in vivo using PET.<br /><br /> A one-pot, two-step automated synthesis of N-(5-[<br /><br /> F]fluoropentyl)maleimide (60min synthesis time, &gt; 98% radiochemical purity) has been developed, which was used to label the single cysteine residue in C2Am within 30min at room temperature. Binding of <br /><br /> F-C2Am to apoptotic and necrotic tumor cells was assessed in vitro, and also in vivo, by dynamic PET and biodistribution measurements in mice bearing human tumor xenografts treated with a TRAILR2 agonist or with conventional chemotherapy. C2Am detection of tumor cell death was validated by correlation of probe binding with histological maw kidney retention allowed the spatial distribution of cell death in a tumor to be imaged during the course of therapy, providing a rapid assessment of tumor treatment response. <br /><br /> F-C2Am has the potential to be used in the clinic to assess early treatment response in tumors.<br /><br />The rapid clearance of 18F-C2Am from the blood pool and low kidney retention allowed the spatial distribution of cell death in a tumor to be imaged during the course of therapy, providing a rapid assessment of tumor treatment response. [https://www.selleckchem.com/products/ipa-3.html IPA-3] 18F-C2Am has the potential to be used in the clinic to assess early treatment response in tumors.<br /><br /> Availability of the α<br /><br /> -adrenoceptor (α<br /><br /> -AR) positron emission tomography (PET) tracer, [<br /><br /> C]ORM-13070, and the α<br /><br /> -AR antagonist ORM-12741 allows probing of the roles of this G-protein coupled receptor subtype in brain function, both in healthy humans and in patients with various brain disorders. This translational study employed [<br /><br /> C]ORM-13070 autoradiography and PET to determine α<br /><br /> -AR occupancy by ORM-12741 in rat and human brain, respectively.<br /><br /> ORM-12741 has high affinity (K<br /><br /> 0.08nM) and potent antagonist activity (K<br /><br /> 0.04nM) as well as selectivity (K<br /><br /> estimates for the human α<br /><br /> -AR and α<br /><br /> -AR were 8.3nM and 0.8nM, respectively) for the human α<br /><br /> -AR subtype. [<br /><br /> C]ORM-13070 had highest uptake in the basal ganglia of rat and human brain. Pretreatment with ORM-12741 inhibited [<br /><br /> C]ORM-13070 binding in rat striatum in a time- and dose-dependent manner at 10 and 50µg/kg (s.c.) with an EC<br /><br /> estimate of 1.42ng/mL in rat plasma, corresponding to protein-free drug concentration of 0.23nM. In the living human brain, time- and dose-related α<br /><br /> -AR occupancy was detected with EC<br /><br /> estimates of 24ng/mL and 31ng/mL for the caudate nucleus and putamen, respectively, corresponding to protein-free concentrations in plasma of 0.07nM and 0.1nM. Modelling-based maximum α<br /><br /> -AR occupancy estimates were 63% and 52% in the caudate nucleus and the putamen, respectively.<br /><br /> ORM-12741 is a selective α<br /><br /> -AR antagonist which penetrates the rat and human brain to occupy α<br /><br /> -ARs in a manner consistent with its receptor pharmacology. Trial registration number and date of registration ClinicalTrial.cov NCT00829907. Registered 11 December 2008. https//clinicaltrials.gov/ .<br /><br />ORM-12741 is a selective α2C-AR antagonist which penetrates the rat and human brain to occupy α2C-ARs in a manner consistent with its receptor pharmacology. Trial registration number and date of registration ClinicalTrial.cov NCT00829907. Registered 11 December 2008. https//clinicaltrials.gov/ .Recent evidence suggests that the processing of observed actions may reflect an action prediction error, with more pronounced mediofrontal negative event-related potentials (ERPs) for unexpected actions. This evidence comes from an application of a false-belief task, where unexpected correct responses elicited high ERP amplitudes. An alternative interpretation is that the ERP component reflects vicarious error processing, as objectively correct responses were errors from the observed person's perspective. In this study, we aimed to disentangle the two possibilities by adding the factor task difficulty, which varied expectations without affecting the definition of (vicarious) errors, and to explore the role of empathy in action observation. We found that the relationship between empathy and event-related potentials (ERPs) mirrored the relationship between empathy and behavioral expectancy measures. Only in the easy task condition did higher empathy lead to stronger expectancy of correct responses in the true-belief and of errors in the false-belief condition.