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Interestingly, decreasing NO2 concentration due to lockdown was associated with international travel controls but not with public transport closure. Increasing NO2 concentration was associated with the "business as usual" strategy as evident from North America and Europe during the early days of COVID-19 outbreak (late January to early February 2020), as well as in recent days (in late April) after many countries have started to resume economic activities. This study enriches our understanding of the heterogeneous patterns of global associations among the COVID-19 spreading, lockdown policies and their environmental impacts on NO2 dynamics.Microbes simultaneously drive multiple functions (multifunctionality) that support human well-being. However, the structure and function of microbial communities and their impact on soil multifunctionality following grassland afforestation remains unknown, thus hindering our ability to formulate conservation policies. We compared soil bacterial and fungal communities, soil abiotic properties, and soil nitrogen (N) function and multifunctionality in the afforested sites that were previously grassland, on a subtropical plateau in China. We also explored the degree to which the niche complementarity effect and the selection effect of microbes are linked to soil N function and multifunctionality. We found that afforestation of grassland significantly decreased pH, available N concentration and density, and soil multifunctionality. However, afforestation significantly increased C (carbon) limitation and shifted soil microbes from being limited by N to, instead, being co-limited by N and P (phosphorus). The signifibial taxonomic diversities by optimizing soil abiotic environments might improve soil multifunctionality.To date, numerous studies have focused on the toxicity of antimony (Sb) to soil-dwelling organisms at the individual level. However, little is known about Sb-caused molecular level toxicity. Here, an integrated transcriptomics and metabolomics approach was used to better reveal toxicity of Sb(V) to springtails Folsomia candida considering environmentally relevant speciation of Sb. No significant effects of Sb(V) on survival, reproduction and growth of springtails were observed using the ISO standard test. Transcriptomics analysis identified 1015 and 3367 differentially expressed genes (DEGs) after 2 and 7 d of exposure, indicating an increasing transcriptomal changes with time. Significantly enriched top GO (Gene Ontology) terms (chitin metabolic process, chitin binding and extracellular region) were shared between the two time exposure groups. However, no enriched KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway was shared, with fatty acid metabolism and apoptosis-fly being the most significant pathway, respectively. Metabolomics analysis identified 155 differential changed metabolites (DCMs) in springtails after 7 d of exposure. Antifolate resistance was the most significantly enriched pathway, in which dihydrofolic acid was up-regulated and three purine nucleotides (adenosine 5'-monophosphate, inosine 5'-monophosphate, guanosine 5'-monophosphate) were down-regulated. This indicated obvious repression of DNA replication, which was also observed by transcriptomics. Additionally, metabolites level related to chitin, oxidative stress, and protein metabolism significantly changed, and these metabolites could also support and confirm main transcriptomic results. Thus, the combination of multiomics facilitated better understanding of the molecular level of toxicity of Sb(V) in Collembola.<br /><br /> Accurate and timely forecasts of bacillary dysentery (BD) incidence can be used to inform public health decision-making and response preparedness. However, our ability to detect BD dynamics and outbreaks remains limited in China.<br /><br /> This study aims to explore the impacts of meteorological factors on BD transmission in four representative regions in China and to forecast weekly number of BD cases and outbreaks.<br /><br /> Weekly BD and meteorological data from 2014 to 2016 were collected for Beijing (Northern China), Shenyang (Northeast China), Chongqing (Southwest China) and Shenzhen (Southern China). A boosted regression tree (BRT) model was conducted to assess the impacts of meteorological factors on BD transmission. Then a real-time forecast and early warning model based on BRT was developed to track the dynamics of BD and detect the outbreaks. The forecasting methodology was compared with generalized additive model (GAM) and seasonal autoregressive integrated moving average model (SARIMA) that have been used to ming and outbreak alert of BD in China.<br /><br />Temperature plays the most important role in weather-attributable BD transmission. The BRT model achieved a better performance in comparison with GAM and SARIMA in most study cities, which could be used as a more accurate tool for forecasting and outbreak alert of BD in China.In the outbreak of infectious diseases such as COVID-19, social media channels are important tools for the public to obtain information and form their opinions on infection risk, which can affect their disease prevention behaviors and the consequent disease transmission processes. However, there has been a lack of theoretical investigation into how social media and human behaviors jointly affect the spread of infectious diseases. In this study, we develop an agent-based modeling framework that couples (1) a general opinion dynamics model that describes how individuals form their opinions on epidemic risk with various information sources, (2) a behavioral adoption model that simulates the adoption of disease prevention behaviors, and (3) an epidemiological SEIR model that simulates the spread of diseases in a host population. [https://www.selleckchem.com/products/GSK1904529A.html click here] Through simulating the spread of a coronavirus-like disease in a hypothetical residential area, the modeling results show that social media can make a community more sensitive to external drivers. Social media can increase the public's awareness of infection risk, which is beneficial for epidemic containment, when high-quality epidemic information exists at the early stage of pandemics. However, fabricated and fake news on social media, after a "latent period", can lead to a significant increase in infection rate. The modeling results provide scientific evidence for the intricate interplay between social media and human behaviors in epidemic dynamics and control, and highlight the importance of public education to promote behavioral changes and the need to correct misinformation and fake news on social media in a timely manner.