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Long right vertebral artery may appear in the surgical field of the thoracoscopic esophagectomy. Knowledge of such anatomical variation is important to prevent iatrogenic injury of the right vertebral artery and the right reccurent laryngeal nerve.<br /><br />Long right vertebral artery may appear in the surgical field of the thoracoscopic esophagectomy. Knowledge of such anatomical variation is important to prevent iatrogenic injury of the right vertebral artery and the right reccurent laryngeal nerve.<br /><br /> Fine needle aspiration (FNA) of the thyroid gland is an effective and safe method for evaluating thyroid nodules; catastrophic complications following FNA of thyroid are rare. Massive hematomas with active bleeding leading to airway compromise are extremely rare complications of FNA, with only a few reported cases in literature.<br /><br /> An 80year-old man presented to the emergency room with severe respiratory distress, four hours after undergoing thyroid FNA for the evaluation of a thyroid nodule. An axial neck computed tomography (CT) revealed a large hematoma in the retropharyngeal space that caused anterior deviation of the trachea, with extravasation of contrast media suggesting active bleeding within the hematoma. Right subclavian angiography identified active bleeding from the right inferior thyroid artery (ITA). Transcatheter arterial embolization (TAE) was successfully performed with n-Butyl cyanoacrylate (NBCA). Follow-up CT done three weeks after the procedure revealed a low-density lesion in the retropharyngeal space, indicating an old hematoma. The patient recovered well and was discharged 6weeks later.<br /><br /> Massive hemorrhage arising from the ITA is a rare but possible complication following FNA, which can potentially be fatal. Appropriate preventive measures should be taken while performing FNA, especially in patients on long-term anticoagulant drugs, and prompt intervention is mandatory for patients with acute hematoma after FNA.<br /><br />Massive hemorrhage arising from the ITA is a rare but possible complication following FNA, which can potentially be fatal. Appropriate preventive measures should be taken while performing FNA, especially in patients on long-term anticoagulant drugs, and prompt intervention is mandatory for patients with acute hematoma after FNA.<br /><br /> We aimed to formulate a novel predictive nomogram to discriminate liver fibrosis stage in patients with chronic liver disease.<br /><br /> Nomograms were established based on the results of multivariate analysis. The predictive accuracy of the nomograms was assessed by ROC analysis and calibration. Decision curve analysis (DCA) was used to determine the clinical benefit of the nomograms.<br /><br /> INR, platelets, and N-terminal propeptide type III collagen (PIIINP) were independent predictors for advanced liver fibrosis (≥ S3) and cirrhosis (S4) in patients with chronic liver disease in the training cohort. In the training set, the areas under the ROCs (AUROCs) of nomogram S3S4, APRI, FIB-4, and GPR for stage ≥ S3 were 0.83, 0.71, 0.68, and 0.74, respectively; the AUROCs of nomogram S4, APRI, FIB-4, and GPR for stage S4 were 0.88, 0.74, 0.78, and 0.79, respectively. The calibrations showed optimal agreement between the prediction by the established nomograms and actual observation. In the validation set, the AUROCs of nomogram S3S4, APRI, FIB-4, and GPR for stage ≥ S3 were 0.86, 0.79, 0.78, and 0.81, respectively; the AUROCs of nomogram S4, APRI, FIB-4, and GPR for stage S4 were 0.88, 0.77, 0.81, and 0.83, respectively. Furthermore, the decision curve analysis suggested that the nomograms represent better clinical benefits in both independent cohorts than APRI, FIB-4, and GPR.<br /><br /> The constructed nomograms could be a superior tool for discriminating advanced fibrosis and cirrhosis in chronic liver disease.<br /><br />The constructed nomograms could be a superior tool for discriminating advanced fibrosis and cirrhosis in chronic liver disease.<br /><br /> Pulmonary mucormycosis caused by Mucorales is a highly lethal invasive fungal infection usually found in immunocompromised patients. Isolated pulmonary mucormycosis in immunocompetent patients is very rare. Here, we present a case of a 32-year-old male who developed pulmonary mucormycosis without any known immunodeficiency.<br /><br /> The patient presented to our hospital because of cough and chest pain along with blood in the sputum. He was first treated for community-acquired pneumonia until bronchoalveolar lavage fluid culture confirmed the growth of Absidia. His symptoms were relieved with the use of amphotericin B, and he eventually recovered. We also provide a systematic review of relevant literature to summarize the characteristics of pulmonary mucormycosis in immunocompetent patients.<br /><br /> Pulmonary mucormycosis has variable clinical presentations and is difficult to identify. [https://www.selleckchem.com/products/terephthalic-acid.html Selleckchem Terephthalic] Due to its high fatality rate, clinicians should make judgements regarding suspected cases correctly and in a timely manner to avoid misdiagnosis and delayed treatment.<br /><br />Pulmonary mucormycosis has variable clinical presentations and is difficult to identify. Due to its high fatality rate, clinicians should make judgements regarding suspected cases correctly and in a timely manner to avoid misdiagnosis and delayed treatment.<br /><br /> Infliximab-induced seizures in patients with Crohn's disease are extremely rare and the mechanism of infliximab-induced seizures is unclear.<br /><br /> A 60-year-old woman with Crohn's disease experienced infliximab-induced seizures, diagnosed on normal magnetic resonance imaging of the brain. Moreover, the rechallenge with infliximab was positive.<br /><br /> Neurological assessment and tight clinical monitoring before and during therapy with infliximab should be performed in patients with pre-existing seizure disorders.<br /><br />Neurological assessment and tight clinical monitoring before and during therapy with infliximab should be performed in patients with pre-existing seizure disorders.<br /><br /> Senile osteoporosis with age-related bone loss is diagnosed depending on radiographic changes of bone and bone mineral density (BMD) measurement. However, radiographic alterations are usually signs of medium-late stage osteoporosis. Therefore, biomarkers have been proposed as indicators of bone loss. In the current study, Galectin-1 (Gal-1) showed age-related decline in mice serum. The role of Gal-1 in osteoporosis has not been investigated so far. Hence, the current study illustrated the relationship of serum Gal-1 level with bone loss.<br /><br /> We employed 6- and 18-month-old mice to establish an animal model of age-related trabecular bone loss, whose bone density and microstructure were investigated by micro-CT. ELISA was used to measure the levels of Gal-1 in serum. The correlation analysis was performed to illustrate the relationship between serum Gal-1 levels and trabecular bone loss. In addition, immunohistochemistry was used to investigate the abundance of Gal-1 in bone marrow of mice. ELISA and western blot were performed to measure the secretion ability and protein expression of Gal-1 in bone marrow stromal cells (BMSC), hematopoietic stem cells (HSC) and myeloid progenitor (MP) respectively.