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Moreover, the suturing applications in rat and minipig models are realized by employing the mechanically strong fibers. Therefore, this work opens a new direction for the production of biological fibers from natural sources. © 2020 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim.Erythrosine B sensitized TiO2 photocatalysis has been combined with Ru(II)-catalysis to accomplish an oxidative olefination/annulation of benzoic acids with activated olefins under mild conditions that tolerates useful functionalities, such as halides, free hydroxy, acetamido, etc. The morphology of the photocatalyst is unaffected during the reaction and it can be reused. Mechanistic studies favor the involvement of a photo-induced single electron transfer process. © 2020 Wiley-VCH Verlag GmbH &amp; Co. KGaA, Weinheim.The photoinitiated thiol-ene addition reaction is a highly stereo- and regioselective, and environmentally friendly reaction proceeding under mild conditions, hence it is ideally suited for the synthesis of carbohydrate mimetics. A comprehensive study on UV-light-induced reactions of 2,3-unsaturated O-, C-, S- and N-glycosides with various thiols was performed. The effect of experimental parameters and structural variations of the alkenes and thiols on the efficacy and regio- and stereoselectivity of the reactions was systematically studied and optimized. The type of anomeric heteroatom was found to profoundly affect the reactivity of 2,3-unsaturated sugars in the thiol-ene couplings. Hydrothiolation of 2,3-dideoxy O-glycosyl enosides efficiently produced the axially C2-S-substituted addition products with high to complete regioselectivity. Moderate efficacy and varying regio- and stereoselectivity were observed with 2,3-unsaturated N-glycosides and no addition occurred onto the endocyclic double bond of C-glycosides. Upon hydrothiolation of 2,3-unsaturated S-glycosides, the addition of thiyl radicals was followed by elimination of the thiyl aglycone resulting in 3-S-substituted glycals. ©2020 The Authors. Published by Wiley-VCH Verlag GmbH &amp; Co. KGaA.LSD1 is a lysine demethylase highly involved in initiation and development of cancer. To design highly effective covalent inhibitors, a strategy is to fill its large catalytic cleft by designing tranylcypromine (TCP) analogs decorated with long, hindered substituents. We prepared three series of TCP analogs, carrying aroyl- and arylacetylamino (1 a-h), Z-amino acylamino (2 a-o), or double-substituted benzamide (3 a-n) residues at the C4 or C3 position of the phenyl ring. Further fragments obtained by chemical manipulation applied on the TCP scaffold (compounds 4 a-i) were also prepared. When tested against LSD1, most of 1 and 3 exhibited IC50 values in the low nanomolar range, with 1 e and 3 a,d,f,g being also the most selective respect to monoamine oxidases. In MV4-11 AML and NB4 APL cells compounds 3 were the most potent, displaying up to sub-micromolar cell growth inhibition against both cell lines (3 a) or against NB4 cells (3 c). The most potent compounds in cellular assays were also able to induce the expression of LSD1 target genes, such as GFI-1b, ITGAM, and KCTD12, as functional read-out for LSD1 inhibition. Mouse and human intrinsic clearance data highlighted the high metabolic stability of compounds 3 a, 3 d and 3 g. Further studies will be performed on the new compounds 3 a and 3 c to assess their anticancer potential in different cancer contexts. © 2020 Wiley-VCH Verlag GmbH &amp; Co. KGaA, Weinheim.Elevated atmospheric CO2 (eCO2 ) generally increases carbon input in rice paddy soils and stimulates the growth of methane-producing microorganisms. Therefore, eCO2 is widely expected to increase methane (CH4 ) emissions from rice agriculture, a major source of anthropogenic CH4 . Agricultural practices strongly affect CH4 emissions from rice paddies as well, but whether these practices modulate effects of eCO2 is unclear. Here we show, by combining a series of experiments and meta-analyses, that whereas eCO2 strongly increased CH4 emissions from paddies without straw incorporation, it tended to reduce CH4 emissions from paddy soils with straw incorporation. Our experiments also identified the microbial processes underlying these results eCO2 increased methane-consuming microorganisms more strongly in soils with straw incorporation than in soils without straw, with the opposite pattern for methane-producing microorganisms. Accounting for the interaction between CO2 and straw management, we estimate that eCO2 increases global CH4 emissions from rice paddies by 3.7%, an order of magnitude lower than previous estimates. Our results suggest that the effect of eCO2 on CH4 emissions from rice paddies is smaller than previously thought and underline the need for judicious agricultural management to curb future CH4 emissions. © 2020 John Wiley &amp; Sons Ltd.This multicenter, randomized, double-blind, parallel-group phase III clinical trial aimed to investigate the efficacy and safety of a rosuvastatin&nbsp;+&nbsp;amlodipine combination compared with that of rosuvastatin or amlodipine monotherapy in hypertensive patients with dyslipidemia. A total of 106 patients of 15 institutions in Korea were randomly assigned to 1 of 3 treatment groups rosuvastatin 20&nbsp;mg&nbsp;+&nbsp;amlodipine 10&nbsp;mg, amlodipine 10&nbsp;mg, or rosuvastatin 20&nbsp;mg. After 8&nbsp;weeks of treatment, the mean&nbsp;±&nbsp;SD of change in mean sitting systolic blood pressure (msSBP) was -22.82&nbsp;±&nbsp;12.99&nbsp;mm Hg in the rosuvastatin&nbsp;+&nbsp;amlodipine group, the most decreased among the treatment groups. The percentage of patients whose msSBP decreased ≥20&nbsp;mm Hg or msDBP decreased ≥10&nbsp;mm Hg was also highest in this group (74.29%). The mean&nbsp;±&nbsp;SD percentage change in low-density lipoprotein cholesterol (LDL-C) level from baseline after 8&nbsp;weeks was -52.53%&nbsp;±&nbsp;11.21% in the rosuvastatin&nbsp;+&nbsp;amlodipine group, the most decreased among the treatment groups. More patients in the rosuvastatin&nbsp;+&nbsp;amlodipine group achieved their target LDL-C goal at 8&nbsp;weeks, compared with the other treatment groups (97.14%). No serious adverse events or adverse drug reactions were observed in all groups. In hypertensive patients with dyslipidemia, combination treatment with rosuvastatin 20&nbsp;mg&nbsp;+&nbsp;amlodipine 10&nbsp;mg effectively reduced blood pressure and LDL-C levels while maintaining safety. © 2020 Wiley Periodicals, Inc.In China, there are approximately 250 million adults who have hypertension with low rates of awareness, treatment and control. Changes in lifestyles at a population level have the potential to enhance or deteriorate the prevention and control of hypertension. We used data from a regional hypertension survey to examine the impact of 2/1&nbsp;mm&nbsp;Hg decreases or increases in population blood pressure on hypertension prevalence, and rates of unawareness of the hypertension diagnosis, treatment, and control. The primary analysis was based on the average blood pressure of respondents from three visits and a diagnostic threshold of 140/90&nbsp;mm&nbsp;Hg for hypertension. Secondary analyses examined average blood pressure from the first survey visit and also a diagnostic threshold of 130/80&nbsp;mm&nbsp;Hg for hypertension. The baseline hypertension prevalence was 33.4%, and rates of unawareness of the hypertension diagnosis, treatment, and control were 74.2%, 25.8%, and 9.7%, respectively. Decreases or increases in blood pressure by 10/5&nbsp;mm&nbsp;Hg resulted in changes in hypertension prevalence (22.1% vs 53.4%) and rates of unawareness of the diagnosis (60.9% vs 83.8%), treatment (39.1% vs 16.2%), and control (21.2% vs 3.6%), respectively. Similar trends were seen in the secondary analyses. Population changes in lifestyle could have a very large impact on the prevalence and control of hypertension in China. The results support implementation of programs to improve population lifestyles while implementing health services policies to enhance the clinical management of hypertension. © 2020 Wiley Periodicals, Inc.It is generally known that acute minor stroke and transient ischemic attack (TIA) seem to be benign. However, their occurrence in patients with steno-occlusive arterial disease may result in early neurological deterioration (END). We aimed to elucidate the effect of blood pressure variability (BPV) on the development of END. Consecutive acute minor stroke and TIA patients within 24&nbsp;hours of onset were prospectively recruited from the Affiliated Hospital of Yangzhou University between Aug 2015 and Feb 2019. END was defined as an NIHSS score increased ≥1 during the first 72&nbsp;hours compared with the initial NIHSS score. During this period, the mean, maximum (max), the difference between the maximum and minimum (max-min), the SD, and coefficient of variation of BP (BPCV ) were calculated. Of the 160 total patients enrolled in the study (mean age, 68.01&nbsp;±&nbsp;9.33&nbsp;years; 50.6% female), 52 (32.5%) patients occurred END during the first 72h after admission. To express the BPV as a categorical variable, we classified the subjects into one of four groups, representing four quartiles of BPV. In the multivariable analyses, the lowest quartiles were considered as reference groups. The results showed that patients who fell in the fourth quartile (SBPmax-min OR&nbsp;=&nbsp;3.289, 95% CI 1.147-9.430; SBPSD OR&nbsp;=&nbsp;3.313, 95% CI 1.041-10.547; SBPCV OR&nbsp;=&nbsp;3.425, 95% CI 1.164-10.077; DBPSD OR&nbsp;=&nbsp;3.124, 95% CI 1.065-9.158) had a significantly higher risk of END after adjusting the variables (age, female, diabetes mellitus, atrial fibrillation, and CRP with P values less then .1 in univariate analyses). Our study demonstrated that the acute in-hospital BPV was associated with the development of END in acute minor stroke and TIA with steno-occlusive arterial disease. © 2020 Wiley Periodicals, Inc.The renal resistive index has been demonstrated to predict the progression of renal disease and recurrence of major cardiac events in high-risk cardiovascular patients, in addition to other comorbidities. We aimed to assess the prognostic significance of the renal resistive index in type 2 diabetic patients for primary prevention. From 2008 to 2011, patients with type 2 diabetes underwent cardiovascular evaluation, including renal resistive index assessment by renal Doppler ultrasound. The incidence of all-cause death, cardiovascular events, dialysis requirement or a twofold increase in creatinine was recorded. Survival curves were estimated by the Kaplan-Meier method. Two hundred sixty-six patients were included; 50% of the patients were men, an HbA1C level of 8.1&nbsp;±&nbsp;1.7% (65&nbsp;±&nbsp;13.6&nbsp;mmol/mol) and a serum creatinine level of 8 [7-9] mg/L. The mean 24-hour systolic blood pressure, 24-hour diastolic blood pressure, and 24-hour pulse pressure were 133.4&nbsp;±&nbsp;16.7, 76.5&nbsp;±&nbsp;9.4, and 56.9&nbsp;±&nbsp;12.4&nbsp;mm&nbsp;Hg, respectively. The median renal resistive index was 0.7 [0.6-0.7] with a threshold of 0.7 predictive of monitored events. After adjustment of the 24-hour pulse pressure, age and 24-hour heart rate, a renal resistive index ≥0.70 remained associated with all-cause death (hazard ratio 3.23 (1.16-8.98); P&nbsp;=&nbsp;.025) and the composite endpoint of major clinical events (hazard ratio 2.37 (1.34-4.18); P&nbsp;=&nbsp;.003). An elevated renal resistive index with a threshold of 0.7 is an independent predictor of a first cardiovascular or renal event in type 2 diabetic patients. This simple index should be implemented in the multiparametric staging of diabetes. © 2020 Wiley Periodicals, Inc.