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We review the improvement of acupuncture on hypertension and psychological stress induced cardiovascular reactivity. We think that acupuncture intervenes hypertension and psychological stress induced cardiovascular reactivity to prevent cardiovascular disease and cardiovascular death. We also summarize relation between acupuncture and central orexinergic system. We propose a hypothesis that acupuncture improve hypertension and psychological stress induced cardiovascular reactivity through regulating central orexinergic system. The knowledge is beneficial for the development of potential therapeutic targets and methods to prevent cardiovascular disease and cardiovascular death.TW-like infectious bronchitis virus (IBV) with high pathogenicity is becoming the predominant IBV type circulating in China. To develop vaccines against TW-like IBV strains and investigate the critical genes associated with their virulence, GD strain was attenuated by 140 serial passages in specific-pathogen-free embryonated eggs and the safety and efficacy of the attenuated GD strain (aGD) were examined. The genome sequences of GD and aGD were also compared and the effects of mutations in the S gene were observed. The results revealed that aGD strain showed no obvious pathogenicity with superior protective efficacy against TW-like and QX-like virulent IBV strains. The genomes of strains aGD and GD shared high similarity (99.87 %) and most of the mutations occurred in S gene. Recombinant IBV strain rGDaGD-S, in which the S gene was replaced with the corresponding regions from aGD, showed decreased pathogenicity compared with its parental strain. In conclusion, attenuated TW-like IBV strain aGD is a potential vaccine candidate and the S gene is responsible for its attenuation. Our research has laid the foundation for future exploration of the attenuating molecular mechanism of IBV.<br /><br /> Women with severe mental illnesses (SMI) may have elevated rates of hypertensive disorders in pregnancy (HDP) due to an accumulation of risk factors. This study aims to determine the prevalence rate of HPD within a population of women with SMI and to report on rates within different mental illness diagnoses and types of medication exposure.<br /><br /> A retrospective multicentre study of 521 pregnant women attending specialised antenatal clinics for the management of established SMI.<br /><br /> Measures included sociodemographic characteristics, pregnancy complications, mental health diagnosis and psychotropic medication use.<br /><br /> Overall, 14% of women in the study had HDP. Compared to women with non-affective psychotic and other non-psychotic disorders (10.3%), women with depression and anxiety disorders demonstrated an increased risk of having a diagnosis of HDP (18.8%; RR=1.82 [95% CI 1.01, 3.29], p=.048). Log-binomial regression demonstrated that both a BMI in the overweight and obese range (RR=3.37 [95% CI 1.04, 10.95], p=.044) and continuous SNRI treatment throughout pregnancy (RR=2.79 [95% CI; 1.33, 5.83], p=.006) were significant predictors of HDP, after adjusting for maternal age, gestational diabetes, and other mental health diagnoses.<br /><br /> Women with severe mental illnesses have elevated risk of developing HPD. Management remains complex and should address their comorbid risk profiles, and weigh up the risks and benefits of psychotropic medication use, given these results provide evidence of elevated rates of HDP associated with exposure to SNRI when taken throughout pregnancy.<br /><br />Women with severe mental illnesses have elevated risk of developing HPD. Management remains complex and should address their comorbid risk profiles, and weigh up the risks and benefits of psychotropic medication use, given these results provide evidence of elevated rates of HDP associated with exposure to SNRI when taken throughout pregnancy.<br /><br /> The main objective of this study is to identify the prevalence of hearing loss in school aged children of Nepal.<br /><br /> This cross-sectional study was carried out on school aged children attending the government run schools of Nepal. A total of 79,340 children from grades 1 through 10 were included in the study. After taking brief history about ear diseases and hearing loss, children were screened for ear diseases in their respective classroom by otoscope. Hearing evaluation was carried out by pure tone audiometer and hearing threshold was obtained at 0.5-4kHz. The results were then documented and analyzed.<br /><br /> The prevalence of hearing impairment in school aged children in Nepal is found to be 5.73% (4551 of 79,340). Conductive hearing loss was the most common type of hearing loss and was observed in 70.47% (n=3207) of the children.<br /><br /> This study shows that hearing loss is a common problem in children of Nepal. With the main cause of hearing loss due to preventable conditions such as chronic otitis media, it is bevent hearing loss.The use of biochar to stabilize soil contaminants is emerging as a technique for remediation of contaminated soils. In this study, an environmental assessment of systems where biochar produced from wood waste with energy recovery is used for remediation of soils contaminated with polycyclic aromatic hydrocarbons (PAH) and metal(loid)s was performed. Two soil remediation options with biochar (on- and off-site) are considered and compared to landfilling. The assessment combined material and energy flow analysis (MEFA), life cycle assessment (LCA), and substance flow analysis (SFA). The MEFA indicated that on-site remediation can save fuel and backfill material compared to off-site remediation and landfilling. However, the net energy production by pyrolysis of wood waste for biochar production is 38% lower than incineration. The LCA showed that both on-site and off-site remediation with biochar performed better than landfilling in 10 of the 12 environmental impact categories, with on-site remediation performing further.<br /><br /> This study assesses the clinical value of dual-energy computed tomography (DECT) in the early diagnosis of intracranial hemorrhage and evaluates the risk of hemorrhagic transformation in patients with acute ischemic stroke (AIS) after mechanical thrombectomy.<br /><br /> Patients with AIS who have undergone thrombectomy with Solitaire stent and DECT within one hour after surgery were prospectively enrolled. Linear mixed energy images, virtual non-contrast (VNC) image, and iodine overlay map (IOM) were obtained. Routine CT scan was performed 24 h postoperatively. The sensitivity, specificity, positive and negative predictive values, and accuracy of DECT in the early diagnosis of intracranial hemorrhage was evaluated. [https://www.selleckchem.com/products/BIBR1532.html BIBR 1532 order] The iodine concentration of intracranial lesions was measured by IOM with the follow-up results taken as reference. Receiver operating characteristic (ROC) analysis was performed to obtain the threshold of hemorrhagic transformation and increased bleeding.<br /><br /> Among the 44 patients enrolled in this study, 25 (56.