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8&nbsp;mg&nbsp;L-1) and moderate effects (LD50 of 99.8&nbsp;μg adult-1) against M. domestica. Those from P. arabica and S. satureioides, containing epi-α-cadinol (23.9%), δ-cadinene (21.1%), α-cadinol (19.8%) and germacrene D-4-ol (8.4%), and thymol (25.6%), α-terpineol (24.6%), borneol (17.4%) and p-cymene (11.4%), respectively, were more active on S. littoralis showing LD50 values of 68.9 and 61.2&nbsp;μg larva-1, respectively. Based on our results, the essential oil from A. campestris may be further&nbsp;considered a candidate ingredient for developing botanical larvicides.The rapid pace of economic growth and urbanization in China affects both large and small cities of the country, causing an increase of pollutant concentrations in the air. The South Gobi is one of the main deserts and semidesert regions of the country; therefore, the study of air pollution near the potential source of natural aerosols is of great importance. Data obtained in the period from 1 January 2016 to 31 December 2019 was used to analyze spatial-temporal characteristics of atmospheric pollutants (PM2.5, PM10, SO2, NO2, and CO) in eight cities. Total mean concentrations of PM2.5 and PM10 were 36.1 ± 21.1&nbsp;μg/m3 and 98.6 ± 108.7&nbsp;μg/m3. The occurrence rates of concentrations exceeding the Chinese National Ambient Air Quality Standard (CNAAQS) grade 1 and grade 2 were 40.1% and 5.4% for PM2.5 and 82.9% and 11.64% for PM10 in the region. Total concentrations of SO2, NO2, and CO did not exceed the CNAAQS standard and were 20.8 ± 23.6&nbsp;μg/m3, 22.6 ± 11.9&nbsp;μg/m3, and 0.72 ± 0.39&nbsp;mg/m3, respectively. The PM2.5 to PM10 ratio increased from 0.35 in spring to 0.46 in winter suggesting the predominance of coarse aerosol fractions in the atmosphere. Based on data on aerosol optical depth (AOD) and Ångström exponent (AE) ratio obtained from Moderate Resolution Imaging Spectroradiometer (MODIS), the predominant aerosol types in the region are Clean Сontinental and Mixed. Maximum concentrations of pollutants and the highest AOD values in the region air are observed in spring and winter. Results set forth in this article will be an important basis for further regional studies on air quality and distribution of sources.Articaine (ATC) is one of the most widely used local anesthetics in dentistry. Despite its safety, local toxicity has been reported. This study aimed to develop an ATC-2- hydroxypropyl-β-cyclodextrin inclusion complex (ATC HPβCD) and to assess its toxicity in vitro. The inclusion complex was performed by solubilization, followed by a fluorimetric and job plot assay to determine the complex stoichiometry. Scanning electron microscopy, DOSY- 1 H-NMR, differential scanning calorimetry (DSC), and sustained release kinetics were used to confirm the inclusion complex formation. In vitro cytotoxicity was analyzed by MTT assay and immunofluorescence in HGF cells. Fluorimetric and job plot assay determined the inclusion complex stoichiometry (ATCHPβCD = 11) and complex formation time (400&nbsp;min), as indicated by a strong host/guest interaction (Ka&nbsp;= 117.8&nbsp;M - 1), complexed fraction (f&nbsp;= 41.4%), and different ATC and ATC HPβCD melting points (172&nbsp;°C e 235&nbsp;°C, respectively). The mean of cell viability was 31.87% and 63.17% for 20-mM ATC and 20-mM ATC HPβCD, respectively. Moreover, remarkable cell toxicity was observed with free ATC by immunofluorescence. These results indicate the ATC HPβCD complex could be used to improve the safety of ATC. Further research are needed to establish the anesthetic safety and effectiveness in vivo .Stachydrine is a natural product with multiple protective biological activities, including those involved in preventing cancer, ischemia, and cardiovascular disease. However, its use has been limited by low bioavailability and unsatisfactory efficacy. To address this problem, a series of stachydrine derivatives (A1/A2/A3/A4/B1/B2/B3/B4) were designed and synthesized, and biological studies were carried out in vitro and in vivo. When compared with stachydrine, Compound B1 exhibited better neuroprotective effects in vitro, and significantly reduced infarction size in the model of the middle cerebral artery occlusion rat model. Therefore, Compound B1 was selected for further research on ischemic stroke. Graphical abstract.BACKGROUND Treatment for malignant embryonal brain tumors in young children usually employs cycles of standardly dosed cisplatinum followed by high-dose carboplatinum-containing conditioning with single or tandem autologous stem cell rescue (HDC-ASCR). High-dose carboplatin is potentially nephrotoxic, and additive platinum exposure may acutely impact renal function. Aiming to determine if decrease in renal function during conditioning assessed prior to each carboplatin dose was associated with acute increases in creatinine, requirement for dialysis or transplant-related mortality (TRM). This was a retrospective study of consecutive patients with medulloblastoma (n = 15) / atypical teratoid/rhabdoid tumor (AT/RT, n = 5) receiving HDC-ASCR. Fifteen patients underwent 1 HDC-ASCR (carboplatin × 3 doses/ etoposide/ thiotepa) and 5 patients underwent at least 1 of 3 planned tandem HDC-ASCR (carboplatin × 2 doses/ thiotepa). Renal function was assessed by daily creatinine and nuclear medicine glomerular filtration rate (GFR)/ creatinine clearance before each carboplatin dose. RESULTS In this cohort of 20 patients, 3 had doses of carboplatin omitted due to decreases in GFR 1 did not develop nephrotoxicity, 1 experienced nephrotoxicity without need for dialysis, and 1 required dialysis temporarily but recovered renal function. Two patients did not have GFR changes but developed post-ASCR renal failure requiring dialysis and TRM. CONCLUSION Daily assessment of renal function by GFR, prior each dose of carboplatin during HDC-ASCR, will help in protecting the kidney in heavily treated population of oncology/HSCT patients. Although the study had a small number of patients which is a major limitation of the study, but it points to a serious transplant-related morbidity and mortality. [https://www.selleckchem.com/products/SGI-1776.html Selleckchem SGI-1776] So, larger scale studies are needed to clarify the best approach to carboplatin dosing to insure the optimal balance between efficacy and toxicity.