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There is a debate about the relative contributions of top-down and bottom-up attention to the threat-related attentional bias. In this study we investigated the attentional bias in individuals with social anxiety under conditions of no, low and high visual working memory (WM) load. Event-related potential (ERP) and response time (RT) data were recorded while participants performed the dot-probe task and a concurrent change-detection task. The ERP results revealed that the maximum N2pc effect emerged in no visual WM load condition in individuals with social anxiety. The difference of N2pc effect between high socially anxious (HSA) and low socially anxious (LSA) groups was observed in no visual WM load condition, whereas this difference was eliminated under low and high load conditions. [https://www.selleckchem.com/products/Cediranib.html AZD2171 in vitro] However, no significant main effects or interactions were observed in the behavioral index (reflected by Trial Level-Bias Score variability). Overall, the findings indicate the critical role of top-down attention on social anxiety-related attentional bias, which have important implication for attentional bias modification.The processing of semantically complex speech is a demanding task which can be facilitated by speech-associated arm and hand gestures. However, the role of age concerning the perception of semantic complexity and the influence of gestures in this context remains unclear. The goal of this study was to investigate if age-related differences are already present in early adulthood during the processing of semantic complexity and gestures. To this end, we analyzed fMRI images of a sample of 38 young and middle-aged participants (age-range 19-55). They had the task to listen and to watch a narrative. The narrative contained segments varying in the degree of semantic complexity, and they were spontaneously accompanied by gestures. The semantic complexity of the story was measured by the idea density. Consistent with previous findings in young adults, we observed increased activation for passages with lower compared to higher complexity in bilateral temporal areas and the precuneus. BOLD signal in the left frontal and left parietal regions correlated during the perception of complex passages with increasing age. This correlation was reduced for passages presented with gestures. Median-split based post-hoc comparisons confirmed that group differences between younger (19-23 years) and older adults within the early adult lifespan (24-55 years) were significantly reduced in passages with gestures. Our results suggest that older adults within early adulthood adapt to the requirements of highly complex passages activating additional regions when no gesture information is available. Gestures might play a facilitative role with increasing age, especially when speech is complex.In two ERP experiments, we investigated whether readers prioritize animacy over real-world event-knowledge during sentence comprehension. We used the paradigm of Paczynski and Kuperberg (2012), who argued that animacy is prioritized based on the observations that the 'related anomaly effect' (reduced N400s for context-related anomalous words compared to unrelated words) does not occur for animacy violations, and that animacy violations but not relatedness violations elicit P600 effects. Participants read passive sentences with plausible agents (e.g., The prescription for the mental disorder was written by the psychiatrist) or implausible agents that varied in animacy and semantic relatedness (schizophrenic/guard/pill/fence). In Experiment 1 (with a plausibility judgment task), plausible sentences elicited smaller N400s relative to all types of implausible sentences. Crucially, animate words elicited smaller N400s than inanimate words, and related words elicited smaller N400s than unrelated words, but Bayesian analysis revealed substantial evidence against an interaction between animacy and relatedness. Moreover, at the P600 time-window, we observed more positive ERPs for animate than inanimate words and for related than unrelated words at anterior regions. In Experiment 2 (without judgment task), we observed an N400 effect with animacy violations, but no other effects. Taken together, the results of our experiments fail to support a prioritized role of animacy information over real-world event-knowledge, but they support an interactive, constraint-based view on incremental semantic processing.Social interactions enhance human memories, but little is known about how the neural mechanisms underlying episodic memories are modulated by rewarding outcomes in social interactions. To investigate this, fMRI data were recorded while healthy young adults encoded unfamiliar faces in either a competition or a control task. In the competition task, participants encoded opponents' faces in the rock-paper-scissors game, where trial-by-trial outcomes of Win, Draw, and Lose for participants were shown by facial expressions of opponents (Angry, Neutral, and Happy). In the control task, participants encoded faces by assessing facial expressions. After encoding, participants recognized faces previously learned. Behavioral data showed that emotional valence for opponents' Angry faces as the Win outcome was rated positively in the competition task, whereas the rating for Angry faces was rated negatively in the control task, and that Angry faces were remembered more accurately than Neutral or Happy faces in both tasks. fMRI data showed that activation in the medial orbitofrontal cortex (mOFC) paralleled the pattern of valence ratings, with greater activation for the Win than Draw or Lose conditions of the competition task, and the Angry condition of the control task. Moreover, functional connectivity between the mOFC and hippocampus was increased in Win compared to Angry, and the mOFC-hippocampus functional connectivity predicted individual differences in subsequent memory performance only in Win of the competition task, but not in any other conditions of the two tasks. These results demonstrate that the memory enhancement by context-dependent social rewards involves interactions between reward- and memory-related regions.