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The purpose of the study is to determine the degree of decrease in the intellectual level of people under the age of 45 who have suffered from schizophrenia in childhood and adolescence in comparison with healthy individuals of the same age. 700 patients under the age of 45 years who had schizophrenia from 9 to 18 years old and underwent treatment at the Center for Mental Health and Prevention of Addiction (Tbilisi, Georgia) and 479 healthy people of the same age range were examined. In this work, the IQ intelligence coefficient was selected as the measured variable, which was determined both in the patient group and in the control group according to the Wechsler Abbreviated Scale of Intelligence method and its part concerning non-verbal intelligence was used. During statistical processing of control group data for comparison with a group of patients, the data of unrealistically low values and extremely high IQ values were withdrawn from consideration. For patients, a violation of the law of the normal distribution of the IQ coefficient was obtained. The degrading effect of schizophrenia in childhood and adolescence on IQ is very "significant" and is an explanation for the patients' IQ deviation fact from the normal distribution. The median IQ of the control group of healthy people is slightly more than 117, which can be explained by the influence of personal and contextual (modern social environment) factors.Rosacea is a chronic, recurrent skin disease. It may be aggravated by various factors. An increased&nbsp;incidence&nbsp;of rosacea has been reported in those who carry the stomach&nbsp;bacterium Helicobacter pylori. The purpose of this study was determination of the relationship of this infection with rosacea and to investigate effectiveness of eradication therapy of H. pylori. As our results showed, 80.9% of study patients were infected with H. pillory. There was correlation between infection rates and rosacea severity. In most cases the positive test results for H. Pylori was found in patients with moderate to severe form of disease. The results of the treatment of different forms of rosacea confirmed the effectiveness of the eradication therapy of H. Pylori, regarding as one of the pathogenic cause of rosacea and the way in the choice of treatment. More wide studies of pathophysiological aspects of causes of rosacea will be promising and help in treating rosacea. These data indicate the important role of H.Pylori in the development of rosacea and recommend taking into account in the therapy of this dermatosis.The long-term androgen deficiency (AD) in men with hypothyroidism is an important problem due to the fact that it leads to concomitant cardiac pathology, which remains the leading cause of mortality in the world. The presence of different points of view on the problem of AD and its effect on the risk factors for cardiovascular disease in patients with hypothyroidismattracts attention. The aim of the study is to assess the clinical signs of age-related androgen deficiency and their association with cardiovascular risk factors in men with hypothyroidism. 84 patients were examined, 38 of them - with hypothyroidism and age-related androgen deficiency, 46 patients with hypothyroidism and normal testosterone levels. The control group was formed of 20 men without hypothyroidism. The lipid and carbohydrate metabolism status, the presence and type of obesity, the level of depression, daily blood pressure monitoring were determined. AD was verified by decrease the total testosterone concentration in serum ( less then 12 nmol/L). The level of total testosterone and sex hormone binding globulin in serum were determined by radioimmunoassay analysis. The decrease of testosterone level in men with hypothyroidism is accompanied by an increase in the frequency of abdominal obesity, triglycerides and glucoseescape, and is associated with subclinical depression. In men with hypothyroidism and AD, the average blood pressure in the daytime significantly exceeds the similar rates in patients with hypothyroidism and normal levels of testosterone. The presence of androgen deficiency negatively affects the risk factors of cardiovascular disease in men with hypothyroidism.Growing evidence supports the existence of immune-surveillance mechanisms in ovarian tumour patients, including autoantibodies to tumour associated and tumour specific antigens, tumour growth factors. Glycoprotein hormone human chorionic gonadotropin (hCG) and its hormone-specific hCGβ subunit have been associated with epithelial tumours such as bladder, lung, oral/facial, breast, cervical, ovarian, vaginal, prostate, renal and pancreatic carcinomas. It is believed that hCG plays a role of an autocrine growth factor for tumor cells. Here we have demonstrated that sera of patients with ovarian cyst contain naturally-occurring autoantibodies, predominantly of IgG2 isotype, that bind to hCG and its subunits with high affinity. Titration of blood sera from 36 female patients, aged 22-61 after ethical permission and informed consent, diagnosed with ovarian cyst and healthy age-matched controls (n=12) was performed using a classical enzyme-linked immunosorbent assay (ELISA). Binding of the sera to the following anth bind to hCG and/or its subunits. The overwhelming majority of these autoantibodies belong to the IgG2 isotype thus indicating that they might be directed against carbohydrate antigens within highly glycosylated hCG.Aim - to investigate the effect of oxidative stress on the autonomic nervous system state in patients with liver cirrhosis. In a randomized way with the preliminary startification by the presence of LC 81 patients - 55 (67.9%) males, 26 (32.1%) females, aged 46.9±10.8 years were included to the study after the signing the informed cosent. All the patients underwent the comprehensive clinical laboratory and instrumental examination of all organs and systems in accordance with the requirements of the modern medicine.Among the indicators of redox homeostasis the content of malondialdehyde (MDA) and of catalase (CAT) were determined. [https://www.selleckchem.com/products/kpt-8602.html KPT-8602 inhibitor] The study of autonomic nervous system (ANS) status was carried out using the registration of heart rate variability (HRV) before and after the physical activity. The results were processed on a personal computer in Statistica 6.0, RStudio v. 1.1.442 and R Commander v.2.4-4 using descriptive statistics. The difference was considered statistically significant if p less then 0.05. The results of HRV time parameters analysis before the physical activity revealed that MDA content negatively correlated with mean duration of NN (RR) intervals (RRNN), standard deviation of NN intervals (SDNN), the square root of the mean squared differences of successive NN interval (RMSSD), percent of consecutive NN intervals with difference more then 50 mc between (pNN 50%), percent of variation coefficient (CV%) and positively - with heart rate.