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PURPOSE The aim of the study was to describe young adult use and perceptions of different brands of pod-based electronic cigarettes (e-cigarettes) and compare with earlier types of non-pod-based e-cigarettes (e.g., mods and tanks). METHODS Data were collected from January to March 2019 and derive from the final wave of a cohort study recruited in 2013-2014 using a convenience sample from 10 large California high schools with racially/ethnically and socioeconomically diverse populations. A total of 445 participants completed an online survey (mean age&nbsp;= 20.1 years [SD&nbsp;= 1.66], 64.8% female [n&nbsp;= 278], 38.8% white [n&nbsp;= 161], 23.9% each for Asian and "more than one race" [n&nbsp;= 99], 13.5% other [n&nbsp;=&nbsp;56], and 36.9% Hispanic [n&nbsp;= 160]). The main outcomes were description of and reasons to use pods, perceived nicotine content, and use patterns. RESULTS Although 50% of JUUL ever users did. The most agreed upon reason (58%) for using pods was because they are "easy to hide." About half of pod users "do not know" if they mix brands of e-juice and pods, the nicotine concentration in their e-juice cartridges, nor time to finish a cartridge. Of the 50% of participants who shared their pod, 23 (15%) did "sometimes," 20 (13%) "always," and 16 (11% each) "about half the time" or "often." There was no consensus about how to refer to different brands of pods. CONCLUSIONS Our findings indicate young adults harbor confusion about pod-based e-cigarettes, including nicotine content, usage patterns, and labeling, and that pod use is largely because of the ease with which they can "stealth" vape. The findings suggest needed regulation and education about these products. Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are potentially life-threatening, immune-mediated adverse reactions characterized by widespread erythema, epidermal necrosis, and detachment of skin and mucosa. Efforts to grow and develop functional international collaborations and a multidisciplinary interactive network focusing on SJS/TEN as an uncommon but high burden disease will be necessary to improve efforts in prevention, early diagnosis and improved acute and long-term management. SJS/TEN 2019 From Science to Translation was a 1.5-day scientific program held April 26-27, 2019, in Vancouver, Canada. The meeting successfully engaged clinicians, researchers, and patients and conducted many productive discussions on research and patient care needs. Crown V. All rights reserved.BACKGROUND Poor self-care in patients with hypertension is associated with worse patient outcomes. The Self-Care of Hypertension Inventory (SC-HI) measures self-care in patients with hypertension and includes three scales self-care maintenance, which measures adherence to prescribed treatments and behaviors; self-care management, which evaluates the responses to signs and symptoms of high blood pressure; and self-care confidence, which measures self-efficacy in dealing with the entire process. OBJECTIVE To test the psychometric characteristics of the Brazilian version of the SC-HI. METHODS We enrolled a sample of 360 patients with hypertension and performed confirmatory factor analysis (CFA) and exploratory factor analysis (EFA) to test the factorial structure of the SC-HI and computed the factor score determinacy coefficient to evaluate the SC-HI internal consistency reliability. RESULTS The sample was predominantly female (65%), mean age of 65 years (SD&nbsp;=&nbsp;10), white (70%). The self-care maintenance scale resulted in a unidimensional scale, with supportive fit indices (CFI&nbsp;=&nbsp;0.901, RMSEA&nbsp;=&nbsp;0.048); the self-care management did not reflect the original factorial structure and had unsupportive fit indices. EFA showed a different factorial solution in reference to the original study. Finally, the self-care confidence scale resulted in a unidimensional scale with supportive fit indices (CFI&nbsp;=&nbsp;0.940, RMSEA&nbsp;=&nbsp;0.093). [https://www.selleckchem.com/products/sorafenib.html Sorafenib clinical trial] The reliability of the self-care maintenance, management, and confidence scales resulted in factor score determinacy coefficients of 0.83, 0.78, and 0.97 respectively. CONCLUSION This study shows that the SC-HI is a valid and reliable tool to measure self-care in patients with hypertension among the Brazilian population. BACKGROUND Guillain-Barré syndrome is the most common cause of acute flaccid paresis in childhood. Few validated large-scale population-based data are available concerning pediatric Guillain-Barré syndrome, including incidence, risk factors, and initial clinical characteristics. METHODS In the Danish National Patient Registry, we identified all children aged below 16 years (N = 212) diagnosed with Guillain-Barré syndrome and admitted to any Danish department of pediatrics between 1987 and 2016. A total of 145 (68%) medical files could be retrieved and reviewed, enabling classification of patients with true Guillain-Barré syndrome. The nationwide Guillain-Barré syndrome incidence rate was calculated and stratified by age, gender, time periods, and season. Risk factors and initial Guillain-Barré syndrome characteristics were assessed by medical record review. RESULTS The positive predictive value of Guillain-Barré syndrome diagnosis codes was 86%. The crude Guillain-Barré syndrome incidence rate was 0.69 per 100,000 person years and peaked at two years of age. The incidence rate was higher among men (0.80) than women (0.58) and was relatively stable over the 30-year period. No seasonal difference of the incidence rate was found. Of the 125 Guillain-Barré syndrome cases, 63% were preceded by infection, whereas none were preceded by surgery or malignant disease. Medically treated pain was documented in 70%, mainly confined to the lower extremities. CONCLUSIONS Pediatric Guillain-Barré syndrome diagnoses in the Danish National Patient Registry have high validity, the incidence peaks at the age of two years, and is preceded by infection in two-thirds of children. Lower extremity pain is a common clinical presentation in the acute setting. BACKGROUND Acute flaccid myelitis is characterized by acute-onset flaccid limb weakness with predominantly gray matter lesions in the spinal cord spanning one or more segments. Rates of full recovery are poor, and there is no standard treatment or definitive cause. METHODS This is a retrospective review of children diagnosed with acute flaccid myelitis in Texas during 2016. Patients were identified through a Texas collaborative of six hospitals in four major metropolitan areas. Data abstraction included health history, illness presentation, medical treatments, laboratory studies, imaging data, recovery, and ability to perform activities of daily living up to approximately two&nbsp;years from illness onset. RESULTS Among all sites, 21 patients met inclusion criteria. Treatments varied with the most common being intravenous immunoglobulin, high-dose methylprednisolone, and plasmapheresis. No differences were seen in response to medical treatments. A potential etiology was found in 12 (57%) cases, including four with enterovirus D68. Five cases recovered fully. Of the 16 patients without full recovery, abilities ranged from (1) able to perform all activities of daily living for age independently (n&nbsp;=&nbsp;5), (2) mild deficits (n&nbsp;=&nbsp;5), and (3) substantial reliance on caregivers for activities of daily living (n&nbsp;=&nbsp;6). CONCLUSION Many reports describe symptoms and outcomes of acute flaccid myelitis, but limited data are available on long-term functional outcomes. We were unable to make a strong case for any single cause or treatment modality. Fortunately, the majority of patients (15, 71%) were able to perform activities of daily living with complete independence or only mild deficits. Migraine is the leading cause of years lost due to disability in individuals aged 15 to 49&nbsp;years. Much has changed over the last three decades about our understanding of this complex neurological disorder. Various phases of migraine have been characterized and are the focus of this review. The premonitory phase involves bothersome symptoms experienced hours to days before migraine pain. Behavioral changes and functional neuroimaging studies point toward hypothalamic involvement during the premonitory and other migraine phases. Migraine aura is a disruptive, reversible neurological phenomenon that affects up to one-third of all migraineurs, and can overlap with the headache phase. The mechanism responsible for this phase is thought to be cortical spreading depolarization through the cortex. This process leads to temporary disruptions in ion homeostasis and the ensuing neuronal dysfunction. The headache phase involves activation of the trigeminocervical complex. Neuropeptides are implicated in trigeminal activation, and calcitonin gene-related peptide in particular has become a promising target of therapeutic intervention for migraine. The final phase of migraine is the postdrome, the period of time from the resolution of headache symptoms until return to baseline following a migraine. People often report neuropsychiatric, sensory, gastrointestinal, and general symptoms during this time, which can limit activity. Elucidating the neuroanatomical, chemical, and neuroimaging correlates of these migraine phases allows for an improved comprehension of the underlying changes associated with migraine symptomatology and can assist with evaluation of arising therapeutics for migraine management. BACKGROUND In patellofemoral replacement (PFR) coronal alignment is mostly influenced by local condylar anatomy. However, there is still a lack of consensus regarding references to follow intraoperatively for the optimal positioning of the trochlear component. The aim of this study was to assess whether aiming for the anatomical femoral axis on the coronal plane leads to improved clinical outcomes and whether coronal alignment correlates with clinical outcomes. METHODS Forty-two patients who underwent PFR were retrospectively evaluated at a minimum one-year follow-up using Kujala and Knee Society Score (KSS). Moreover, patients underwent an anteroposterior hip-to-knee X-ray to evaluate the coronal alignment of the trochlear component with respect to the femoral anatomic and mechanical axis. Prosthesis coronal alignment, Kujala, and KSS were assessed for possible correlation. RESULTS Mean follow-up time 29.1&nbsp;months. Mean KSS for pain 90 (±8.9), for function 93.7 (±15.9); mean Kujala 89.2 (±13.6). Mean prosthesis coronal alignment was 3.3&nbsp;±&nbsp;2.3° in valgus with respect to the femoral anatomic axis and 7.4&nbsp;±&nbsp;2.6° in valgus with respect to the femoral mechanical axis. No correlations were found between coronal alignment and KSS or Kujala scores. CONCLUSIONS Results from the current study showed that PF replacement with a third-generation implant led to good-to-excellent outcomes. In addition, the surgical technique used for aligning femoral component in this study resulted in reduced coronal alignment variability and achieved good short-term clinical outcomes. V.Transurethral resection of bladder tumour is the initial, most critical step in the management of bladder cancer; as such, this is a call to arms for the urological community to it the due diligence it deserves regarding technology and training.