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Abdominoplasty has been evolving since the 1960s with many technical innovations throughout the years. It has become one of the most frequent and common procedures done in aesthetic plastic surgery, with the ultimate goal of not only to remove the excess tissue in the abdominal area but also to achieve an aesthetic trunk silhouette.<br /><br /> The prime objective of this article was to describe our preferred approach for a full cosmetic abdominoplasty.<br /><br /> We summarized all the key technical aspects from our shared surgical approach for abdominoplasty. The article describes collective experiences from authors performing the surgery in South America, North America, and Asia.<br /><br /> The key technical aspects identified were conservative muscle plication, customized excess tissue resection, and ultrasound-assisted liposuction to improve definition in the abdominal lines and body curves, combined with lipofilling. The aesthetic results are presented.<br /><br /> Abdominoplasty should be customized to every patient's anatomy and desired cosmetic outcome, taking into consideration all the anatomical areas surrounding the abdominal wall.<br /><br />Abdominoplasty should be customized to every patient's anatomy and desired cosmetic outcome, taking into consideration all the anatomical areas surrounding the abdominal wall.Apelin is a new adipocytokine that acts as an endogenous hormone in various tissues through its receptor (APJ). This study aimed to investigate the effects of oral administration of L-carnitine (LC) on the expression of Apelin and APJ in adipose tissue of experimentally induced insulin-resistant and type 2 diabetic rats. In this experimental study, 60 male rats fed with high fat/high carbohydrate (HF/HC) diet. After 50 mg/kg intraperitoneally injection of streptozotocin (STZ) and confirmation of diabetes (FBS higher than 126 mg/dl), the animals were daily treated with 300 mg/kg LC for 28 days. At days 7, 14, and 28 of posttreatment, the expression of apelin and APJ in adipose tissue were determined using qPCR in diabetic, diabetic + LC treated, control, and control + LC treated groups. Apelin, insulin, TNF-α, and IL1-β were measured by the ELISA method. Results demonstrated that the rats fed with the HF/HC diet for 5 weeks were hyperinsulinemic and normoglycemic, while after STZ injection, they showed hyperinsulinemia and hyperglycemia with higher levels of HOMA-IR. Apelin serum level, APJ and apelin gene expression in adipose tissue increased significantly with the development of diabetes compared to the control group. Treatment with LC for 14 days caused a reduction in apelin and APJ expressions in adipose tissue of diabetic rats. TNF-α and IL1-β levels were reduced in diabetic rats 14 days after their treatment with LC. The study results show that L-carnitine could act as a new regulator in apelin gene expression in adipose tissue, improving the metabolic disorders in diabetic patients.<br /><br /> Inhaled drugs are the most commonly used class of medications for COPD subjects. No studies have been performed to assess the influence of smoking on lung deposition of aerosolized medication, especially for the exacerbated COPD subject. The present study aimed to assess the influence of smoking on the lung deposition of the aerosol delivered to exacerbated COPD subjects.<br /><br /> Twenty-four exacerbated COPD subjects using automatic continuous positive airway pressure (Auto-CPAP), 12 smokers (six females) and 12 non-smokers (six females) were recruited in the study. The subjects participated in the study received four salbutamol study doses; 1200µg (12 puffs 100µg/puff) of salbutamol emitted from pMDI canister connected to AeroChamber MV spacer; 1200µg of salbutamol emitted from pMDI canister connected to Combihaler spacer; 1mL of salbutamol respirable solution (5000µg/mL) nebulized by Aerogen Solo connected to its T-piece; and 1mL of salbutamol respirable solution nebulized by Aerogen Solo connected to Combihalen. Further studies are needed.<br /><br />The study demonstrated that smoking reduced the lung deposition of inhaled salbutamol delivered by nebulizer or pMDI. However, the smoking effect on cytochrome p450 was observed to increase systemic absorption of the ingested portion of the inhaled dose. The lower lung deposition and possible higher systemic absorption should be taken into consideration while prescribing inhaled medication to COPD smokers especially exacerbated patients that need ventilation. Further studies are needed.Significant research has been dedicated to counteracting age-related muscle loss, but underlying mechanisms have not been clearly established. Previous research examining differences in basal protein kinetics between young and older individuals has been limited by a lack of evaluation of protein breakdown and net balance. The aim of this study was to more comprehensively examine differences in basal protein kinetics between younger and older males and females. Basal whole-body protein kinetics and muscle fractional synthetic rate (FSR) from 91 younger (18-38 years; 52% female) and 66 older (51-81 years; 53% female) healthy adults were determined using stable isotope tracer techniques (L-[ring-2 H5 ]phenylalanine and L-[ring-2 H2 ]tyrosine). [https://www.selleckchem.com/products/ms-275.html find more] There were no group × sex interaction effects (p &gt; .05). Older individuals had greater whole-body protein synthesis (mean difference old-young (Δ) ± SE 28.54 ± 8.15 mg/kg LBM/hr; p = .001) and breakdown (Δ 15.44 ± 7.33 mg/kgLBM/hr; p = .038), but a less negative net balance (Mean ± SD Young -31.22 ± 7.42 mg/kg LBM/hr; Old -18.11 ± 21.60 mg/kg LBM/hr; p less then .001) compared to young individuals. Basal FSR was not significantly different between young and older (Δ 0.007 ± 0.003%/hr; p = .052). Across the age range, females had greater whole-body protein turnover (PSΔ 19.10 ± 7.00 mg/kgLBM/hr; PBΔ 19.22 ± 6.31 mg/kgLBM/hr; p less then .01) compared to males. Results demonstrate a difference in basal whole-body protein kinetics between young and older adults, with older adults having a higher protein turnover rate and a less negative net balance. Across the age range, females were also found to have a higher turnover rate compared to males. Differences may represent a shift in older physiology toward mechanisms that increase the efficiency of amino acid reutilization, especially in women.