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The present study demonstrated the ability of a novel platform, self-propelling MAS particles, to trigger hemostasis by puncturing RBCs. To the best of our knowledge, this is the first trial in which the release of endogenous procoagulants is promoted without the addition of exogenous procoagulants for severe hemorrhage control.Due to their specific spinel structure, ternary oxides with multi-catalytic sites on a highly active exposed surface are recommended as alternative bio-catalysts. Spinel zinc vanadate with two-dimensional nanosheets (Zn3V3O8 NSs) was synthesised using a one-step hydrothermal route with CTAB and glycine as a bi-surfactant, where each NS has a thin thickness (25 nm) and wide cross section (2 μm). [https://www.selleckchem.com/products/AZD1480.html AZD1480 supplier] As a key parameter for peroxidase-like activity, the Michaelis-Menten constant (Km) for Zn3V3O8 NSs was calculated to be 0.271 mM with TMB and 1.317 mM with H2O2 at optimum conditions, indicating a higher affinity for the exposed (011) facet towards horseradish peroxidases. This affinity is related to the geometric matching between V4+ active sites and the terminal amino groups of TMB. The V4+ ions on the (011) facet act as dangling bonds and readily react with H2O2 in a Fenton-like reaction. The peroxidase-like activity for Zn3V3O8 NSs is verified by the formation of [V(IV)-OO˙] by the ˙O2- and V5+ near V4+ sites, but oxidase activity for Zn3V3O8 NSs. Based on the peroxidase-like activity, Zn3V3O8 NSs were used as a colorimetric glucose sensor with a wide linear range from 0.01 to 0.5 mM and a detection limit (LOD = 3σ/S) of 2.81 × 10-7 M. The colorimetric sensor also exhibited high accuracy and selectivity in synthetic perspiration samples.Titanium dioxide is a food additive that has raised some concerns for humans due to the presence of nanoparticles. We were interested in knowing the fate of TiO2 particles in the gastro-intestinal tract and their potential effect on digestive enzymes. For this purpose, we analysed the behaviour of two different food grade TiO2 samples (E171) and one nano-sized TiO2 sample (P25) through a standardized static in vitro digestion protocol simulating the oral, gastric and intestinal phases with appropriate juices including enzymes. Both E171 and P25 TiO2 particles remained intact in the digestive fluids but formed large agglomerates, and especially in the intestinal fluid where up to 500 μm sized particles have been identified. The formation of these agglomerates is mediated by the adsorption of mainly α-amylase and divalent cations. Pepsin was also identified to adsorb onto TiO2 particles but only in the case of silica-covered E171. In the salivary conditions, TiO2 exerted an inhibitory action on the enzymatic activity of α-amylase. The activity was reduced by a factor dependent on enzyme concentrations (up to 34% at 1 mg mL-1) but this inhibitory effect was reduced to hardly 10% in the intestinal fluid. In the gastric phase, pepsin was not affected by any form of TiO2. Our results hint that food grade TiO2 has a limited impact on the global digestion of carbohydrates and proteins. However, the reduced activity specifically observed in the oral phase deserves deeper investigation to prevent any adverse health effects related to the slowdown of carbohydrate metabolism.A series of half-sandwich polypyridyl complexes was synthesized and compared focusing on structural, cytotoxic and aqueous solution behaviour. The formula of the synthesized complexes is [M(arene)(N,N)Cl]Cl, where M Ru or Rh, arene p-cymene, toluene or C5Me5-, (N,N) 2,2'-bipyridine (bpy), 4,4'-dimethyl-2,2'-bipyridine (dmb), 1,10-phenanthroline (phen) or 2,9-dimethyl-1,10-phenanthroline (neo). The structures of five half-sandwich complexes were determined by X-ray crystallography. It was found that introducing methyl groups next to the coordinating nitrogen atoms of the bidentate ligand causes steric congestion around the metal centre which changes the angle between ligand planes. The ligands and the Rh complexes showed significant cytotoxicity in A2780 and MES-SA cancer cell lines (IC50 = 0.1-56 μM) and in the cisplatin-resistant A2780cis cells. Paradoxically, phen and dmb as well as their half-sandwich Rh complexes showed increased toxicity against multidrug resistant MES-SA/Dx5 cells. In contrast, coordinalinear regression procedure.This frontiers article highlights recent developments of the use of N-heterocyclic silylenes (NHSis), the higher homologues of the Arduengo-carbenes, as ambiphilic activators and ligands in organometallic chemistry and provides a comparison of five-membered ring NHSi ligands with ubiquitous N-heterocyclic carbene (NHC) and phosphine ligands. The frontier orbital region of NHSis differs considerably from that of NHCs which results in different ligation properties. The donor properties of NHSis are closer to those of phosphines than to those of NHCs. NHSis reveal a much stronger tendency to act as bridging ligands between two metal centres than NHCs or phosphines and NHSi insertion reactions into metal-ligand bonds are more facile to achieve compared to similar insertion reactions of NHCs. These interesting properties clearly distinguish NHSi ligands from their NHC or phosphine counterparts and should provide novel reactivities in basic organometallic chemistry and catalysis.The reactivity of a paramagnetic T-shaped cobalt(i) complex, [(iPrboxmi)Co], stabilised by a monoanionic bis(oxazolinylmethylidene)-isoindolate (boxmi) NNN pincer ligand is described. The exposure to carbon monoxide as an additional neutral ligand resulted in the square-planar species [(iPrboxmi)Co(CO)], accompanied by a change in the electronic spin state from S = 1 to S = 0. In contrast, upon treatment with trimethylphosphine the formation of the distorted tetrahedral complex [(iPrboxmi)Co(PMe3)] was observed (S = 1). Reacting [(iPrboxmi)Co] with iodine (I2), organic peroxides (tBu2O2, (SiMe3)2O2) and diphenyldisulphide (Ph2S2) yielded the tetracoordinated complexes [(iPrboxmi)CoI], [(iPrboxmi)Co(OtBu)], [(iPrboxmi)Co(OSiMe3)] and [(iPrboxmi)Co(SPh)], respectively, demonstrating the capability of the boxmi-supported cobalt(i) complex to homolytically cleave bonds and thus its distinct one-electron reactivity. Furthermore, a square-planar cobalt(ii) alkynyl complex [(iPrboxmi)Co(CCArF)] was identified as the main product in the reaction between [(iPrboxmi)Co] and a terminal alkyne, 4-fluoro-1-ethynylbenzene.