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Monotherapy results mimicked clinical trial outcomes. Upon chronic exposure to HCQ and AZM polytherapy, we observed an increase in QT interval on days 4-8. Interestingly, a decrease in arrhythmias and instabilities was observed in polytherapy relative to monotherapy, in concordance with published clinical trials. Biomarkers, most of them measurable in patients' serum, were identified for negative effects of monotherapy or polytherapy on tissue contractile function, morphology, and antioxidant protection. The cardiac MPS correctly predicted clinical arrhythmias associated with QT prolongation and rhythm instabilities. This high content system can help clinicians design their trials, rapidly project cardiac outcomes, and define new monitoring biomarkers to accelerate access of patients to safe coronavirus disease 2019 (COVID-19) therapeutics.The aim of this study was to investigate the therapeutic effects of vacuum sealing drainage (VSD) on wound repair time and inflammation-related indicators in patients with soft-tissue wounds in comparison with traditional treatment. From January 2018 to January 2020, 130 enrolled patients with soft-tissue wounds were randomly divided into two groups VSD group (65 cases) and routine dressing change (RDC) group (65 cases). The inflammation-related indicators including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), white blood cell (WBC), and procalcitonin (PCT) of preoperative stage and postoperative day 3 (POD 3) and POD 7 were recorded. Wound healing was observed 3 and 7 days after treatment, and the clinical efficacy, changes in the wound (coverage rate and thickness of granulation tissue and bacterial clearance rate), wound-cleaning time, wound-healing time, and hospital stay time were recorded after treatment as well. No significant difference was observed in terms of the baseline between the two groups. On POD 3 and POD 7, CRP, WBC, and PCT levels in the VSD group were lower than those in the RDC group, while ESR levels were higher, with significant differences (P  less then  .05). After treatment, the wound-cleaning time, wound-healing time, and hospital length of stay of the VSD group were all lower than those of the RDC group, with significant differences (P  less then  .05). VSD has a significant effect on the treatment of patients with soft-tissue wounds, which can effectively shorten the time of wound healing and reduce inflammation-related indicators. Compared with traditional RDC, VSD is more worthy of clinical application.<br /><br /> Minéral 89 (M89), comprised of 89% Vichy mineralizing water and hyaluronic acid, has been formulated to help strengthen and restore skin barrier.<br /><br /> Assess tolerance and efficacy of M89 in post-esthetic procedures and dry skin-related facial dermatoses.<br /><br /> Adults post-esthetic procedure or presenting with inflammatory dermatoses (47 subjects; mean age 40.9±13.2years; any Fitzpatrick or skin phototype), applied M89 for 4weeks, once or twice daily, as an adjuvant treatment. Information on clinical signs and subject-reported symptoms, skin characteristics, tolerance, and subject and investigator satisfaction were collected.<br /><br /> Following 4weeks of M89 use, significant decreases with complete resolution of erythema (27.6%), desquamation (29.8%), irritation (32%), and skin dehydration (35.8%), as compared to baseline signs and symptoms, were observed. Overall grading improvements for erythema (84.8%; p&lt;0.001), desquamation (91.7%; %; p&lt;0.003), irritation (91.7%; %; p&lt;0.015), and skin hydration (46.2%; p&lt;0.015) were noted. There was no significant improvement in papules and pustules. Evaluation of subjective signs demonstrated significant decreases in skin sensations such as burning (-73%; p&lt;0.0001), itching (-71%; p&lt;0.0001), stinging-tingling (-66.7%; p&lt;0.0001), as well as in skin dryness (-60%; p&lt;0.0001). [https://www.selleckchem.com/ selleck chemicals] M89 texture was rated very pleasant by 90% of patients. Investigators assessed M89 tolerance to be either good or very good (93%), and satisfactory or highly satisfactory impact on patient's skin (91.5%).<br /><br /> M89 is a highly tolerable adjuvant treatment that significantly improved clinical signs and symptoms related to a compromised skin barrier in various facial dermatoses and post-aesthetic procedures.<br /><br />M89 is a highly tolerable adjuvant treatment that significantly improved clinical signs and symptoms related to a compromised skin barrier in various facial dermatoses and post-aesthetic procedures.<br /><br /> Occurrence of multiple biotic stresses on crop plants result in drastic yield losses which may have severe impact on the food security. It is a challenge to design strategies for simultaneous management of these multiple stresses. Hence, establishment of innovative approaches that aid in their management is critical. Here, we have introgressed a micro RNA-induced gene silencing (MIGS) based combinatorial gene construct containing seven target gene sequences of cotton leaf curl disease (CLCuD), cotton leaf hopper (Amrasca biguttula biguttula), cotton whitefly (Bemisia tabaci) and root-knot nematode (Meloidogyne incognita).<br /><br /> Stable transgenic lines of Nicotiana benthamiana were generated with the T-DNA harboring Arabidopsis miR173 target site fused to fragments of Sec23 and ecdysone receptor (EcR) genes of cotton leaf hopper and cotton whitefly. It also contained C2/replication associated protein (C2/Rep) and C4 (movement protein) along with βC1 gene of betasatellite to target CLCuD, and two FMRFamide-like pccessful validation of the MIGS approach in the model plant, N. benthamiana for efficacy against M. incognita, as a prelude to translation to cotton. © 2021 Society of Chemical Industry.<br /><br /> Corn intercropped with ruzigrass is common in Brazil, and it can improve the physicochemical features of soils, increase water retention, and suppress the emergence of resistant weeds and soil nematodes. As both corn and ruzigrass are hosts to Spodoptera frugiperda (the main corn pest in South America), the cultivation of both these plants in the same place at one time motivates investigation into the pest population dynamics. We hypothesize that the intercropping system influences S. frugiperda pressure and leaf injury in corn. Considering that if corn hybrids with high dose toxin expression are used, ruzigrass may be a potential host to susceptible S. frugiperda larvae, consequently an alternative refuge and be included as a tool for the resistant management of Bt corn. To test these hypotheses about the use of ruzigrass as an alternative host of S. frugiperda in an intercropping system with corn, we conducted field trials in three seasons to verify S. frugiperda population dynamics and leaf injury to crop systems.