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f the genetic variance of the trait. These results are very encouraging for efforts towards implementation of a breeding strategy aimed at improving resistance to paratuberculosis in Holstein cows.BACKGROUND In conjunction with an automated external defibrillator (AED) placement program at various locations within a public university in Malaysia, a series of structured training programs were conducted. The objectives of this study is to (1) evaluate the effectiveness of a structured training program in improving the perception of the importance of AED and cardiopulmonary resuscitation (CPR), (2) evaluate the confidence of the employees in using an AED and performing bystander CPR, (3) identify the fears and concerns of these employees in using AED and performing CPR, and (4) determine the perception of these employees towards the strategy of the AEDs placed at various locations within the university. METHODS In this single-center observational study, a validated questionnaire aimed to assess the university employees' attitude and confidence in handling AED and performing CPR before (pre-test) and immediately after (post-test) the training program was conducted. RESULTS A total of 184 participants partion of positive attitude, positive societal expectation, and a positive sense of empowerment. But whether this positive effect will translate into actual CPR performance and AED application in a real cardiac arrest is yet to be seen.BACKGROUND Migraine carries a high global burden, disproportionately affects women, and has been implicated as a risk factor for cardiovascular disease. Migraine with aura has been consistently associated with increased risk of cardiovascular mortality. However, published evidence on relationships between migraine or non-migraine headache and all-cause mortality is inconclusive. Therefore, we aimed to estimate the effect of non-migraine headache and migraine as well as migraine subtypes on all-cause and cause-specific mortality in women. [https://www.selleckchem.com/products/sr18662.html SR18662 ic50] METHODS In total,&nbsp;27,844 Women's Health Study&nbsp;participants, aged 45 years or older at baseline, were followed up for a median of 22.7 years. We included participants who provided information on migraine (past history, migraine without aura, or migraine with aura) or headache status and a blood sample at study start. An endpoints committee of physicians evaluated reports of incident deaths and used medical records to confirm deaths due to cardiovascular, cancer, or female-specad an increased risk of cardiovascular death. Future studies should investigate the reasons for the increased risk of cardiovascular mortality and evaluate whether changes in migraine patterns across the life course have differential effects on mortality.OBJECTIVE Aim of this paper was to evaluate advantages of RG technique on PET/CT performance in lung lesions. The impact of 4D-PET/CT for diagnosis (metabolic characterization), staging and re-staging lung cancer were also assessed, including its application for radiotherapy planning. Finally, new technologies for respiratory motion management were also discussed Methods A comprehensive electronic search of the literature was performed by using Medline database (PubMed) searching "PET/CT" and "gated" and "lung". Original articles, review articles, and editorials published in the last 10 years were selected, included and critically reviewed in order to select relevant articles. RESULTS Many papers compared Standardized Uptake Value (SUV) in gated and ungated PET studies showing an increase in SUV of gated images, particularly for the small lesions located in medium and lower lung. In addition, other features as Metabolic Tumor Volume (MTV), Total Lesion Glycolysis (TLG) and textural-features presented differences when obtained from gated and ungated PET acquisitions. Beside the increase in quantification, gating techniques can determine an increase in the diagnostic accuracy of PET/CT. Gated PET/CT was evaluated for lung cancer staging, therapy response assessment and for radiation therapy planning. CONCLUSION New technologies able to track motion of organs lesion directly from raw PET data, can reduce or definitively solve problems (i.e. extended acquisition time, radiation exposure) currently limiting the use of gated PET/CT in clinical routine. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND Chemotherapy of tumors remains one of the most important methods for the treatment of cancer. More recently in this context, some products derived from natural products have raised scientific interest. These includes especially many terpenes. Thereby, diterpenoids represent a special class, and within this class of important secondary natural products especially compounds derived from dehydroabietylamine (DA) are of particular interest. RESULTS This review gives a summary of the most important findings on the cytotoxic behavior of DA-derived compounds but also shows some drawbacks of these, such low bioavailability and/or poor solubility of several derivatives of DA. It focusses on the chemical aspects and summarizes the DA related biological effects without deep discussion of underlying biochemical pathways. CONCLUSION Dehydroabietylamine-derived cytotoxic compounds hold a high potential to be developed into efficient antitumor active drugs. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Lymphoma refers to a specialized category of blood cancers which is characterized by lymph node enlargement, reduced body weight, prolonged tiredness and fever associated with sweats. Traditional treatment strategies involve chemotherapy, radiation therapy, targeted therapy, and surgery. Copanlisib has emerged as a very potent drug which acts through inhibiting PI3K enzyme. FDA has approved it for specific treatment of follicular Lymphoma in September 2017. Copanlisib induces tumor cell death along with prevention of proliferation of dominant malignant β-cells. Copanlisib has a large volume of distribution i.e. 871L (%CV 47.4), plasma protein binding upto 15.8%, plasma half-life(t1/2) of 39.1h and mean systemic plasma clearance 18.9 L/h (%CV 51.2). In the present review various aspects related to Copanlisib have been summarized which include pathophysiology, synthetic strategy, pharmacokinetics, pharmacodynamics and clinical studies. A special emphasis is given on various reported adverse effect and in silico/ in vivo studies conducted on Copanlisib.