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PRR1-10.2196/25746.<br /><br />PRR1-10.2196/25746.<br /><br /> Clinical terms mentioned in clinical text are often not in their standardized forms as listed in clinical terminologies because of linguistic and stylistic variations. However, many automated downstream applications require clinical terms mapped to their corresponding concepts in clinical terminologies, thus necessitating the task of clinical term normalization.<br /><br /> In this paper, a system for clinical term normalization is presented that utilizes edit patterns to convert clinical terms into their normalized forms.<br /><br /> The edit patterns are automatically learned from the Unified Medical Language System (UMLS) Metathesaurus as well as from the given training data. The edit patterns are generalized sequences of edits that are derived from edit distance computations. The edit patterns are both character based as well as word based and are learned separately for different semantic types. In addition to these edit patterns, the system also normalizes clinical terms through the subconcepts mentioned within them.<br /><br /> The system was evaluated as part of the 2019 n2c2 Track 3 shared task of clinical term normalization. It obtained 80.79% accuracy on the standard test data. This paper includes ablation studies to evaluate the contributions of different components of the system. A challenging part of the task was disambiguation when a clinical term could be normalized to multiple concepts.<br /><br /> The learned edit patterns led the system to perform well on the normalization task. Given that the system is based on patterns, it is human interpretable and is also capable of giving insights about common variations of clinical terms mentioned in clinical text that are different from their standardized forms.<br /><br />The learned edit patterns led the system to perform well on the normalization task. Given that the system is based on patterns, it is human interpretable and is also capable of giving insights about common variations of clinical terms mentioned in clinical text that are different from their standardized forms.<br /><br /> The successful recruitment and retention of health professionals to rural and remote areas of Australia is a health policy priority. Nursing or allied health professional students' learning placements in the Northern Territory (NT) of Australia, most of which is considered remote, may influence rural or remote work location decisions.<br /><br /> The aim of this study is to determine where allied health professionals and nurses who have had a student placement in the NT of Australia end up practicing.<br /><br /> This research is an observational cohort study, with data collection occurring at baseline and then repeated annually over 10 years (ie, 2017-2018 to 2029). The baseline data collection includes a demographic profile of allied health and nursing students and their evaluations of their NT placements using a nationally consistent questionnaire (ie, the Student Satisfaction Survey). The Work Location Survey, which will be administered annually, will track work location and the influences on work location decisions.<br /><br /> This study will generate unique data on the remote and rural work locations of nursing and allied health professional students who had a placement in the NT of Australia. It will be able to determine what are the most important characteristics of those who take up remote and rural employment, even if outside of the NT, and to identify barriers to remote employment.<br /><br /> This study will add knowledge to the literature regarding rates of allied health and nursing professionals working in remote or rural settings following remote or rural learning placements. The results will be of interest to government and remote health workforce planners.<br /><br /> Australian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12620000797976; https//www.anzctr.org.au/ACTRN12620000797976.aspx.<br /><br /> PRR1-10.2196/21832.<br /><br />PRR1-10.2196/21832.<br /><br /> Approximately 50% of patients with non-metastatic prostate cancer are treated with radical prostatectomy (RP). While some men will be cured with surgery alone, a substantial proportion will experience cancer recurrence. Androgen-directed therapy (ADT) is an effective adjuvant therapy for patients treated with prostate radiation. Comparatively, the efficacy of ADT in surgical patients has not been well-studied.<br /><br /> A systematic search of MEDLINE, Embase, and the Cochrane Library from inception to July 2020 was performed. Randomized trials comparing ADT with RP vs. prostatectomy alone in patients with clinically localized prostate cancer were included. Neoadjuvant ADT and adjuvant ADT interventions were assessed separately. The primary outcomes were cancer recurrence-free survival (RFS) and overall survival (OS). Pathological outcomes following neoadjuvant ADT were also evaluated.<br /><br /> Fifteen randomized trials met eligibility criteria; 11 evaluated neoadjuvant ADT (n=2322) and four evaluated adjuvant ADT (n=5205)vant ADT for RP patients.The addition of a fourth year to the hospital pharmacy residency program has allowed trainees to rotate through various inpatient clinical units where they can, under the supervision of a specialist pharmacist, work shoulder to shoulder with other healthcare providers to ensure that patients receive the care they need. [https://www.selleckchem.com/products/oligomycin-a.html Oligomycin A datasheet] In addition to sharing their pharmacotherapeutic and pharmacokinetic knowledge (among others) with their colleagues, hospital pharmacists can and should contribute with their expertise in the areas of drug evaluation, selection and positioning. As no other healthcare professional masters like a pharmacist the intricacies of treatment efficacy or effectiveness, or of therapeutic safety, conveying this knowledge is yet another of the many clinical activities a hospital pharmacist must perform as a member of a multidisciplinary team, while assisting fellow-team members in deciding what medications are best suited to each patient. Both the public authorities and the pharmaceutical profession as a whole should make sure the pharmacist's role is rightfully valued and given the recognition it deserves.<br /><br /> To present a new dexamethasone mouthwash formulationand analyze its effectiveness and safety among patients receiving stomatitis-producing antineoplastic agents.<br /><br /> Prospective observational study conducted in a university hospitalbetween March 2017 and November 2019. Consecutive patientsstarting everolimus were enrolled. Patients were instructed to rinse dexamethasonemouthwash formulation twice daily until discontinuation ofeverolimus. A second cohort of patients with existing stomatitis inducedby high probability of producing stomatitis chemotherapy therapies wasalso recruited to assess treatment effectiveness. Effectiveness and safety ofdexamethasone mouthwash formulation was assessed.<br /><br /> Dexamethasone mouthwash formulation was prescribed in ninepatients as prophylaxis. Six patients were diagnosed with breast cancer,two with neuroendocrine tumor and one with renal cell carcinoma. Fourpatients developed mild stomatitis (grade 1-2) and three patients discontinuedeverolimus due to other treatment-related adverse events.