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This paper describes two experiments conducted to investigate changes in the autonomic nervous system and axillary temperature caused by electric potential therapy. The former was investigated using a frequency analysis of successive heartbeats (RR intervals) and cortisol in saliva. The experimental results on the RR intervals suggest no significant change in the autonomic nervous system, but those on the saliva cortisol indicate a change in the system during the therapy. The axillary temperature showed a significant increase. The results on the autonomic nervous system seem inconsistent, and these results as well as future directions were discussed.Patients with deep brain stimulation (DBS) devices have limited access to magnetic resonance imaging (MRI) due to safety concerns associated with RF heating generated around the implant. The problem of predicting RF heating of conductive leads is complex with a large parameter space and several interplaying factors. Recently however, off-label use of MRI in patients with DBS devices has been reported based on limited safety assessments, raising the concern that potentially dangerous scenarios may have been overlooked. In this work, we present results of a systematic assessment of RF heating of a commercial DBS device during MRI at 1.5T and 3T, taking into account the effect of device configuration, imaging landmark, and patient's body composition. Ninety-six (96) RF heating measurements were performed using anthropomorphic phantoms implanted with a full DBS system. We evaluated eight clinically relevant device configurations, implanted in phantoms with different material compositions, and imaged at three different landmarks (head, shoulder, and lower chest) in 1.5 T and 3T scanners. We observed a substantial fluctuation in the RF heating depending on phantom's composition and device configuration. RF heating in the brain-mimicking gel varied from 0.1°C to 12°C during 1.5 T MRI and from less then 0.1°C to 4.5°C during 3T MRI. We also observed that certain device configurations consistently reduced RF heating across different phantom compositions, imaging landmarks, and MRI transmit frequencies.A miniaturized intracerebral potential recorder for long-term local field potential (LFP) of deep brain signals is proposed. LFP can be recorded by deep brain electrodes. The abnormal beta-band oscillation of LFP in subthalamic nucleus and internal globus pallidus in patients with Parkinson's disease (PD) are associated with the severity of the symptoms. The LFP signal from patients who have been implanted with deep brain electrode can be monitored by our system for at least 24 hours in real time. Graphical user interface has also been developed for use by medical personnel. Imitation experiments and in vivo experiments were performed to successfully verify that our system can measure LFP signals. With 24-hour intracerebral signals, researchers can analyze what is happened in the brain in daily life. In the future, more effective PD treatment can be developed, such as intelligent closed-loop deep brain stimulation.Long-term preclinical study available extracranial brain activator (ECBA) system, ECBAv2, is proposed for the non-anesthetic canine models. The titanium-packaged module shows enhanced durability, even after a year of implantation in the scalp. In addition, the wearable helmet type base station provides a stable experimental environment without anesthesia. In this work, HFS stimulation is induced to six canine models for 30 minutes every day over 4 weeks (10Hz, 40Hz and no stimulation for each pair of subjects). Pre- and post-HFS stimulation PET-CT image shows remarkable increases of glucose metabolism in the temporal and parietal lobes. Moreover, both the 40-Hz and 10-Hz groups shows noticeable increase and the former group has more increments than the latter. [https://www.selleckchem.com/products/h-151.html H-151 concentration] Our results establish that HFS stimulation definitely worked as facilitating brain activity which may affect memory and sensory skills, respectively.Cerebral palsy is a neurodevelopmental condition that affects 17 million individuals worldwide. Traditionally, methods of therapy are repetitive and monotonous, generating immense difficulty in maintaining patient motivation and engagement. This project's objective was to provide a novel method of therapeutic intervention that was co-designed by therapists and had the capacity to increase patient motivation and enjoyment. The system developed incorporated the use of muscle activations retrieved from a bespoke surface electromyography subsystem, to control custom computer games to increase therapy uptake. The safety and functionality of this device was verified through a series of trials performed on adults without any muscular impairments. Furthermore, a feasibility evaluation was conducted whereby the system was demonstrated to a group of healthcare professionals to gain their feedback. The trial results confirmed the safety and functionality of the system, with professional therapists confirming its clinical potential and its perceived benefits.Clinical assessment of Multiple Sclerosis relies heavily on the Expanded Disability Status Scale, a non-linear rating system based on physician assessment of disease progression and walking ability. This inherently makes this method both subjective and limited in repeatability. This study developed a technically derived outcome measure of posture to compare a cohort of Multiple Sclerosis and Control subjects during an Eyes-Open and Eyes-closed task. Analysing traditional sway parameters and a multiscale entropy derived complexity index of posturography showed a significant difference in medio-lateral sway between groups during the Eyes-Open condition. This technically derived outcome measure may be of clinical benefit in the longitudinal assessment of the functional impact of balance in MS cohorts and assist in the evaluation of pharmaceutical and rehabilitation interventions.We examined different methods of robotic proprioception assessment and provided comparison with the wrist position sense test gold standard assessment. The aim is to determine which of the assessments are the most reliable and would be acceptable for clinical evaluation. 31 children between six and sixteen participated in a pilot assessment trial and completed all four of the assessments. The assessments included the manual and robotic versions of the wrist position sense test, the joint position matching assessment and the psychometric threshold determination assessment. There was not a significant difference between the manual and robotic wrist position sense tests but there were significant differences with the other assessments. The study also examined the effect of age on the different assessments and found that three of the assessments, excluding the joint position matching assessment, can differentiate between children of different ages. This study concludes that the significant differences between the assessments indicates that proprioception in the wrist is complex and multifaceted.