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A natural polysaccharide-based smart photo-actuator is fabricated via electrospinning of cellulose 4-phenyl azobenzoate (Azo-Cel) from its organic solution in a mixture of high-volatile acetone, a poor solvent of Azo-Cel, and low-volatile N,N-dimethylacetamide (DMAc), a good solvent of Azo-Cel. At an optimal polymer concentration (17 wt%) and solvent mixing ratio (acetone/DMAc = 3/2 (v/v)), stable electrified polymer jets are formed and continuous nanofibers and their nonwoven fabric can be drawn on a cylinder-shaped rotating drum electrode under a high electric field (25 kV). Scanning electron microscopic observation of the Azo-Cel fabric confirms that the fabric consists of uniaxially aligned nanofibers with a mean diameter of 207 nm. The water contact angle of the Azo-Cel fabric reversibly decreases and increases in response to alternate irradiation with UV and visible light to induce geometric deformation of the azobenzene moiety between the trans and cis isomers, which lead to lower and higher surface free energies, respectively. In addition, self-standing Azo-Cel fabric exhibits a UV-driven photo-mechanical asymmetric bending deformation toward the light source.<br /><br /> Hong Kong reduced beer and wine tax in 2007, eliminated taxes on beer and wine and strengthened drink-driving legislation in 2008, and increased police traffic enforcement after the 2014 social unrest. This study aimed to measure the effects of implementing road safety policies on road traffic harm in the context of deregulated alcohol control policy in Hong Kong.<br /><br /> Population-based interrupted time series analysis using seasonal autoregressive integrated moving average (sARIMA) models. Multiple sensitivity analyses were conducted.<br /><br /> Hong Kong, China and Singapore from January 2004 to December 2019.<br /><br /> A total of 313 728 road traffic injuries in Hong Kong and 163 773 road traffic injuries in Singapore as controls.<br /><br /> Monthly rates of road traffic injuries, non-fatal injuries and serious/fatal injuries from Hong Kong and Singapore Police Force.<br /><br /> The elimination of alcohol taxes and the enactment of road safety legislation in 2008 were associated with immediate reductions in total road traffic injuries of 6.71ous/fatal injuries.2D semiconductors are emerging as plausible candidates for next-generation "More-than-Moore" nanoelectronics to tackle the scaling challenge of transistors. Wafer-scale 2D semiconductors, such as MoS2 and WS2 , have been successfully synthesized recently; nevertheless, the absence of effective doping technology fundamentally results in energy barriers and high contact resistances at the metal-semiconductor interfaces, and thus restrict their practical applications. Herein, a controllable doping strategy in centimeter-sized monolayer MoS2 films is developed to address this critical issue and boost the device performance. The ultralow contact resistance and perfect Ohmic contact with metal electrodes are uncovered in monolayer Fe-doped MoS2 , which deliver excellent device performance featured with ultrahigh electron mobility and outstanding on/off current ratio. Impurity scattering is suppressed significantly thanks to the ultralow electron effective mass and appropriate doping site. Particularly, unidirectionally aligned monolayer Fe-doped MoS2 domains are prepared on 2 in. commercial c-plane sapphire, suggesting the feasibility of synthesizing wafer-scale 2D single-crystal semiconductors with outstanding device performance. This work presents the potential of high-performance monolayer transistors and enables further device downscaling and extension of Moore's law.ARID3A is upregulated in colorectal cancer and can promote the proliferation and metastasis of cancer cells. However, patients with higher level of ARID3A have a better prognosis. This study aimed to uncover the mechanism by which ARID3A benefits the prognosis of colon cancer. Our results indicated that ARID3A upregulation enhanced the chemosensitivity of colon cancer cells to 5-fluorouracil (5-FU), whereas ARID3A downregulation inhibited the chemosensitivity of colon cancer cells to 5-FU. Through database analysis, we found that AKR1C3, a drug resistance-related gene, was the target of ARID3A. Moreover, AKR1C3 was downregulated in colon cancer tissues compared to normal tissues. Next, we assessed the interaction between AKR1C3 and ARID3A, and found that ARID3A inhibited the transcription of AKR1C3, leading to the downregulation of AKR1C3 in colon cancer cells. We also verified that AKR1C3 inhibited the chemosensitivity of colon cancer cells to 5-FU. Moreover, patients with higher ratio of ARID3A to AKR1C3 had a better prognosis. This study suggested that ARID3A promoted chemosensitivity of colon cancer cells by inhibiting AKR1C3 in colon cancer. The ratio of ARID3A to AKR1C3 is a good marker to predict the prognosis of colon cancer patients.Metacomposites have attracted widespread attention due to their unique negative electromagnetic properties and stupendous applications. Although there are systems that realize metamaterial properties in low radio frequency bands, the research on the construction of polymer matrix metacomposites with negative performance in the pivotal GHz band is still undiscovered. Herein, carbon nanofiber/conductive polymer metacomposites with 3D overlapping network structures are innovatively constructed to achieve negative permittivity characteristics in the radarwave frequency range, and convenient methods for further adjusting the electromagnetic parameters is also proposed. The results show that the negative permittivity of CNFs/PANI metacomposites can be conveniently altered via adjusting PANI content. [https://www.selleckchem.com/products/shin1-rz-2994.html selleck chemical] Furthermore, electromagnetic shielding has also been fully discussed as one of the most valuable applications of the metacomposites. The SET of CNFs/PANI-70 has an average value of 70 dB at 4-18 GHz and can reach a maximum of 80 dB at 4 GHz, which far exceeds the current commercial electromagnetic shielding standards. This work greatly broadens the promising application of metacomposites for perfect electromagnetic shielding, novel capacitance, and frequency selective surfaces.The concept of the inflammatory pre-metastatic niche (PMN) provides a new and promising direction for the prevention and treatment of metastasis. The excessive activation of the GAS-STING signaling leads to augmented metastasis by promoting the formation of the inflammatory PMN. In this study, tumor-derived microparticles (MP) were used to establish the PMN model both in vitro and in vivo, and pro-inflammatory mediators were also employed to evaluate the effects of Icaritin (ICT). It was demonstrated that ICT could inhibit the pulmonary metastasis of B16BL6 melanoma cells in mice via interfering with PMN. The phosphorylation and dimerization of STING and its downstream signaling TBK1-IFNβ were proved to be diminished in the presence of ICT. Furthermore, we revealed that ICT suppressed the generation of pro-inflammatory PMN through conferring the inactivation of the STING signaling pathway. CETSA and DARTS assay also confirmed that STING tended to be a target for the action of ICT. Collectively, our findings highlight a new binding mechanism between STING and ICT for the inhibition of transduction of the STING signaling pathway, suggesting that pharmacological or therapeutic intervention of the STING-TBK1-IFNβ singling axis may serve as an effective strategy to prevent the progression of inflammatory PMN and lung metastasis.Two decades after the rapid expansion of photovoltaics, the number of solar panels reaching end-of-life is increasing. While precious metals such as silver and copper are usually recycled, silicon, which makes up the bulk of a solar cells, goes to landfills. This is due to the defect- and impurity-sensitive nature in most silicon-based technologies, rendering it uneconomical to purify waste silicon. Thermoelectrics represents a rare class of material in which defects and impurities can be engineered to enhance the performance. This is because of the majority-carrier nature, making it defect- and impurity-tolerant. Here, the upcycling of silicon from photovoltaic (PV) waste into thermoelectrics is enabled. This is done by doping 1% Ge and 4% P, which results in a figure of merit (zT) of 0.45 at 873 K, the highest among silicon-based thermoelectrics. The work represents an important piece of the puzzle in realizing a circular economy for photovoltaics and electronic waste.<br /><br /> Tobacco consumption and its associated adverse outcomes remain major public health issues, particularly in low- and middle-income countries. This systematic review aimed to identify and critically assess full economic evaluations for tobacco control interventions in low- and middle-income countries.<br /><br /> Electronic databases, including EMBASE, MEDLINE and PsycINFO and the grey literature, were searched using terms such as 'tobacco', 'economic evaluation' and 'smoking' from 1994 to 2020. Study quality was assessed using the Consensus Health Economic Criteria and the Philips checklist. Studies were included which were full economic evaluations of tobacco control interventions in low- and middle-income settings. Reviews, commentaries, conference proceedings and abstracts were excluded. Study selection and quality assessment were conducted by two reviewers independently. A narrative synthesis was conducted to synthesize the findings of the studies.<br /><br /> This review identified 20 studies for inclusion. The studies evans in low- and middle-income countries. The methodological limitations of the existing literatures could affect the generalizability of the findings.Invited for the cover of this issue are Yuichi Kitagawa, Yasuchika Hasegawa, and co-workers at Hokkaido University. The image depicts tribo-excited chemical reaction using trivalent lanthanide complexes with stacked anthracene ligands. Read the full text of the article at 10.1002/chem.202104401.<br /><br /> As targeted treatments for amyloid transthyretin cardiomyopathy (ATTR-CM) are becoming available, we aim to characterize the rates of ventricular arrhythmias (VAs), implantable cardioverter-defibrillator (ICD) utilization, and their impact on survival.<br /><br /> This is a retrospective cohort study of 130 patients with ATTR-CM diagnosed at Emory University's Cardiac Amyloidosis Center between April 2012 and September 2020. VAs were defined as nonsustained or sustained ventricular tachycardia and ventricular fibrillation.<br /><br /> Of 130 patients, 42 had wild-type disease (wtATTR) and 88 had hereditary variants (hATTR), most commonly Val122Ile (89%). At ATTR-CM diagnosis, 80 (62%) patients had EF ≤ 40% consistent with systolic heart failure. Of the 69 (53%) patients with documented VAs significantly higher rates occurred among those with EF ≤ 40% compared with EF&gt;40% (67%vs. 28%, p=.001). Thirty-two patients (25 hATTR, 7 wtATTR) had primary prevention ICDs implanted. Eight (25%) of these patients received appropriate ICD therapy while two (6%) experienced inappropriate therapy. Comparing patients with EF ≤ 35% with and without ICDs did not reveal any survival difference (3.3 ± 0.5vs. 2.8 ± 0.4 years, p=.699).<br /><br /> High rates of VAs and appropriate ICD therapy were found among a unique cohort of largely hereditary ATTR-CM patients with a high rate of systolic heart failure.<br /><br />High rates of VAs and appropriate ICD therapy were found among a unique cohort of largely hereditary ATTR-CM patients with a high rate of systolic heart failure.