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that there may be a role for stress management in early pregnancy. V.The present work aimed to discuss the enantiomeric occurrence of chiral pharmaceuticals including 5 parent compounds (PCs) metoprolol, propranolol, atenolol, venlafaxine and fluoxetine as well as 6 of their transformation products (TPs) in surface water in Beijing. Among which, 9 out of 11 were detected during the two sampling campaigns with N-O-Didesmethylvenlafaxine (NODDV) and α-hydroxymetoprolol confirmed in the catchment for the first time. Metoprolol acid (MTPA) was the most abundant up to 1508&nbsp;ng&nbsp;L-1, followed by metoprolol and O-desmethylvenlafaxine (ODV). Most compounds showed 100% detection frequency or nearly, while norfluoxetine (the main metabolite of fluoxetine) and 4-hydroxypropranololone (one TP of propranolol) were not detected. Metoprolol (MTP) and venlafaxine (VFX) did not vary significantly between two sampling periods with mean concentrations of 280.7 and 22.9&nbsp;ng&nbsp;L-1, respectively. Enantiomeric enrichment was observed for venlafaxine, metoprolol and NODDV, where R-venlafaxine was preferentially biotransformed than the S-form through O-desmethylation. [https://www.selleckchem.com/products/taurocholic-acid-sodium-salt-hydrate.html this website] Risk assessment indicated that fluoxetine and atenolol could pose harmful effects to aquatic organisms. This work provides enantiospecific profiles of pharmaceutically active compounds (PhACs), and extended the concept of applying the ratio of TPs vs. parent compound plus their enantiomeric traits for quantitative assessment of in situ biodegradation. Due to the considerable contribution by TPs (64% in present study) as well as the unexpected impacts from enantiomeric existence, the stereoselectivity of chiral pollutants during environmental process should be taken into account in future study. To the best of the authors' knowledge, it is the first comprehensive evaluation of chiral pharmaceuticals and transformation products at enantiomeric level in aquatic environment in China, which would facilitate better understanding of their environmental fate. Drug consumption rooms directly attempt to intervene in and govern the place and time of drug use. Whilst the risk-reducing potentials of these interventions have been thoroughly evaluated, the consumption room literature offers fewer insights into the embodied, affective and situated dynamics that underscore service delivery. In this paper, we take up the notion of atmosphere to explore these dynamics in greater depth. Drawing on 12 months of ethnographic research in a German drug consumption room, we describe the manner in which atmospheres came to pervade and condition service encounters. More than simply providing texture to activities within the consumption room, we show how atmospheres gave rise to a distinct range of bodily capacities and therapeutic effects. Critically, these atmospheric affordances exceeded the risk-reducing objectives of the consumption room to encompass an emergent capacity to find repose, enact respite and foster modes of sociality and care. Our analysis further highlights the contextual contingencies through which the atmospheres of the consumption room emerged, including the efforts of both staff and clients to cultivate and control particular atmospheric qualities. We conclude by considering how closer attention to the atmospheric and affective dimensions of service delivery may challenge how consumption room interventions are enacted, valued and researched. This is to gesture towards a novel, atmospheric mode of harm reduction that has effects by transforming embodied potentials for both staff and clients. Smoking prevalence in Canada has declined; yet, not among all segments of the population. Residents of high-deprivation neighbourhoods and young adults are over-represented among current smokers. There is a dearth of theoretically informed research focused on better understanding the connection between smoking, social inequalities, and place among young adults. To contribute to this understudied area, we undertook a qualitative study drawing upon the collective lifestyles framework. We conducted walking interviews (go-alongs) with 27 young adults (smokers and non-smokers) living in five diverse urban neighbourhoods in Montreal, Canada. We present the findings as neighbourhood portraits wherein participants' accounts revealed how local smoking practices shaped and were shaped by rules and regulations and the meaning and use of neighbourhood resources. In the discussion we reflect on the opportunities and constraints to smoking with a focus on young adults. We also consider the possible implications for socio-spatial inequalities in smoking and the relationship to tobacco control strategies. Milk has been envisaged as a major source of high-quality protein and bioavailable nutrients to humans. Its production is constraint by foot and mouth disease (FMD), a contagious viral disease of very high economic importance worldwide. This study was aimed at assessing the economic impact of FMD in pastoral dairy cattle herds in Nigeria and determines returns to investments in its control to better inform policy decisions. An interview questionnaire-based cross-sectional study was conducted in 660 nomadic and agro-pastoral dairy cattle herds in 2019. Economic impact analyses were conducted using the total economic cost and benefit-cost analysis models. Of the 660 pastoralists enrolled, 92.6% (n = 611) participated. Nomadic pastoralists constituted 50.7% (n = 310) of the respondents while 49.3% (n = 301) were agro-pastoralists. Most of the respondents (66.4%, n = 406) had no formal education. The value of visible losses to the herders was estimated at USD 15,591,694.30 and the cost of control by treatment of secondary infections was USD 463,673.70. The economic impact of FMD due to production losses and costs of treatment to pastoralists was estimated to be USD 16,055,368.00. Return on investment in FMD control was positive with a benefit-cost ratio of 33.6. The estimated total economic costs due to FMD have indicated that it is a disease of high economic importance to dairy production herds and must be controlled to assure food security, local incomes to herders, and protein requirement of human population, especially the children in FMD endemic countries.