Zobrazení zdroje stránky Demirguzman2922

Paeonia delavayi (Paeoniaceae), an endemic plant mainly distributed in southwest China, is always used as the substitute of P. suffruticosa due to their morphological and pharmacological similarity. In the previous study, P. suffruticosa was revealed with antidiabetic potency, whereas the chemical difference and antidiabetic property between different parts of P. delavayi has not yet been studied. This paper was designed to clarify the chemical constituents and antidiabetic potency of P. delavayi by LCMS analysis and enzyme inhibition on α-glucosidase, PTP1B, TCPTP, and DPP4. By interpretation of their UV absorptions and MS fragmentations, and/or comparison with reference samples, 57 constituents comprising 15 flavonoids, 10 monoterpene glycosides, eight triterpenoids, seven galloyl glucoses, six N-containing compounds, five gallic acids, two acetophenones, and four other types of compounds were identified from the different parts of P. delavayi. Moreover, two new monoterpene aglycones (42 and 47) and one newase, but anticompetitive and mix-type inhibitors of PTP1B, respectively. [https://www.selleckchem.com/products/cilofexor-gs-9674.html GS-9674 clinical trial] Docking study demonstrated akebonic acid as PTP1B (over TCPTP) selective inhibitor by bonding to the catalytic sites (B/C) of PTP1B. This LCMS combined with enzymatic comparison opens new sights for recognizing the chemical profiles and antidiabetic potency of P. delavayi.Three maytansinoids with strong cytotoxicities, dehydrotrewiasine, maytanbutine, and trewiasine, were isolated and identified from Trewia nudiflora, and maytanbutine was obtained from this plant for the first time. A quick, easy, cheap, effective, rugged, and safe (QuEChERS) extraction combined with high-performance liquid chromatography (HPLC) was established to determine the three maytansinoids in T. nudiflora. The effects of major factors on the extraction efficiency of the QuEChERS method were evaluated and the optimal conditions using acetonitrile-ethyl acetate (11, v/v) as the extraction solvent and PestiCarb as the clean-up sorbents were established. Compared with Soxhlet extraction (SE) and ultrasonic-assisted extraction (UAE), the QuEChERS method was easy-to-operate and afforded a cleaner extract. A phenomenex HyperClone BDS C18 column was used for HPLC analysis. Methanol-acetonitrile-water was chosen as mobile phase for gradient elution. Method validation showed that all analytes showed good linearity (r &gt; 0.999) over the investigated ranges and satisfactory recoveries ranging from 95.0% to 105.0%. The developed QuEChERS-HPLC method was simple, efficient, and applicable to the determination of maytansinoids in T. nudiflora.An innovative way to treat municipal wastewater and produce energy at the same time is anaerobic treatment. Anaerobic processes are traditionally used for high-strength wastewater or municipal sludge treatment and only recently have been applied for the treatment of low strength municipal wastewater To investigate the performance of anaerobic wastewater treatment through the incorporation of membrane technology, a 40 L laboratory scale Anaerobic Membrane Bioreactor (AnMBR) with a flat sheet submerged membrane along with a 40 L reservoir for trapping and measuring the biogas produced have been installed and set in operation. The scope of this study is to examine, through long term bench scale experiments, the impact that different temperatures and also different operating conditions have on the efficiency of AnMBR in order to identify the possibility of integrating this technology into Wastewater Treatment Plants (WWTPs). This paper evaluates the efficiency of AnMBR in the temperature range 14-26 °C, operating at three different hydraulic retention times (HRTs). The three different HRTs examined were 2 d, 1 d and 12 h. Each HRT is divided into two different temperature ranges. As the HRT decreased the effluent quality decreased and the membrane fouled more rapidly. AnMBR was able to produce permeate water with an average COD of 51 ± 8 mg L-1 at an HRT of 2 d during the summer period with an average temperature of 24 °C. The effluent COD increased to 67 ± 10 mg L-1 and reached 91 ± 5 mg L-1 for HRT 1 d and 12 h respectively for the same temperature range.Manganese oxides (MnO2) are widely applied in heavy metal ions removal due to their low-cost, environmental-friendly and biocompatibility. However, the adsorption capacity of MnO2 need to be further improved to satisfy the demand of practical application. Herein, a highly dispersed single layer NaxKyMnO2 nanosheet was synthesized by a facile wet-chemical method with sodium dodecyl sulfonate as surfactant. The high surface specific area, excellent dispersibility and abundant oxygen vacancies endowed NaxKyMnO2 nanosheets with potential in heavy metal ions adsorption. The adsorption experiments results showed that NaxKyMnO2 nanosheets possessed high efficiency and selectivity towards lead ion (Pb2+) with a high adsorption capacity of 2091.8 μmol g-1. The NaxKyMnO2 also showed an excellent reusability with the removal rate of 95.4% for Pb2+ even after five cycles. Moreover, both the theoretical calculation and experimental data illustrated that the single layer NaxKyMnO2 nanosheets possess high selectivity to Pb2+ adsorption.Designing a cost-effective, high potential and recyclable catalyst remains a challenge. In the present work, a monolithic PAM-GO-Ag hydrogel is prepared by a facile, eco-friendly method using gamma-ray irradiation. The formation of GO-Ag composite by gamma radiation is also investigated and it is authenticated by XRD, FTIR, Raman, XPS and TEM analysis. The PAM-GO-Ag hydrogel exhibits excellent catalytic activity to different catalysant like methylene blue, Rhodamine-B, and pharmaceutical compound ciprofloxacin. The high catalyst carrying capacity and rapid electron shuttling ability of GO plays a significant role in the high performance of PAM-GO-Ag hydrogel. The PAM-GO-Ag hydrogel also exhibits excellent antibacterial activity. The damaged cell membrane, protein leakage, and increased ROS level contribute to the antibacterial activity of PAM-GO-Ag. The monolithic structure of PAM-GO-Ag hydrogel makes it easy to handle, recover, and reuse for several runs without significant loss of catalytic and antibacterial activity.