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Evaluation results illustrate the ability of the framework to localize biological threats and detect infected areas. Moreover, the results show the effectiveness of the reorganization mechanisms in adjusting the environment structure to cope with the highly dynamic environment.Accurate segmentation of lungs in pathological thoracic computed tomography (CT) scans plays an important role in pulmonary disease diagnosis. However, it is still a challenging task due to the variability of pathological lung appearances and shapes. In this paper, we proposed a novel segmentation algorithm based on random forest (RF), deep convolutional network, and multi-scale superpixels for segmenting pathological lungs from thoracic CT images accurately. A pathological thoracic CT image is first segmented based on multi-scale superpixels, and deep features, texture, and intensity features extracted from superpixels are taken as inputs of a group of RF classifiers. With the fusion of classification results of RFs by a fractional-order gray correlation approach, we capture an initial segmentation of pathological lungs. We finally utilize a divide-and-conquer strategy to deal with segmentation refinement combining contour correction of left lungs and region repairing of right lungs. Our algorithm is tested on a group of thoracic CT images affected with interstitial lung diseases. Experiments show that our algorithm can achieve a high segmentation accuracy with an average DSC of 96.45% and PPV of 95.07%. Compared with several existing lung segmentation methods, our algorithm exhibits a robust performance on pathological lung segmentation. Our algorithm can be employed reliably for lung field segmentation of pathologic thoracic CT images with a high accuracy, which is helpful to assist radiologists to detect the presence of pulmonary diseases and quantify its shape and size in regular clinical practices.Rapid increases in data volume and variety pose a challenge to safe drug prescription for health professionals like doctors and dentists. This is addressed by our study, which presents innovative approaches in mining data from drug corpus and extracting feature vectors to combine this knowledge with individual patient medical profiles. Within our three-tiered framework-the prediction layer, the knowledge layer and the presentation layer-we describe multiple approaches in computing similarity ratios from the feature vectors, illustrated with an example of applying the framework in a typical medical clinic. Experimental evaluation shows that the word embedding model performs better than the adverse network model, with a F score of 0.75. [https://www.selleckchem.com/products/crenolanib-cp-868596.html check details] The F score is a common metrics used for evaluating the performance of classification algorithms. Similarity to a drug the patient is allergic to or is taking are important considerations for the suitability of a drug for prescription. Hence, such an approach, when integrated within the clinical work-flow, will reduce prescription errors thereby increasing patient health outcomes.This paper formulates a Model Predictive Control (MPC) policy to mitigate the COVID-19 contagion in Brazil, designed as optimal On-Off social isolation strategy. The proposed optimization algorithm is able to determine the time and duration of social distancing policies in the country. The achieved results are based on data from the period between March and May of 2020, regarding the cumulative number of infections and deaths due to the SARS-CoV-2 virus. This dataset is assumably largely sub-notified due to the absence of mass testing in Brazil. Thus, the MPC is based on a SIR model which is identified using an uncertainty-weighted Least-Squares criterion. Furthermore, this model includes an additional dynamic variable that mimics the response of the population to the social distancing policies determined by the government, which affect the COVID-19 transmission rate. The proposed control method is set within a mixed-logical formalism, since the decision variable is forcefully binary (existence or the absence of social distance policy). A dwell-time constraint is included to avoid too frequent shifts between these two inputs. The achieved simulation results illustrate how such optimal control method would operate in practice, pointing out that no social distancing should be relaxed before mid August 2020. If relaxations are necessary, they should not be performed before this date and should be in small periods, no longer than 25 days. This paradigm would proceed roughly until January/2021. The results also indicate a possible second peak of infections, which has a forecast to the beginning of October. This peak can be reduced if the periods of days with relaxed social isolation measures are shortened.This article describes two spatially-explicit models created to allow experimentation with different societal responses to the COVID19 pandemic. We outline the work to date on modelling spatially-explicit infective diseases and show that there are gaps that remain important to fill. We demonstrate how geographical regions, rather than a single, national approach, are likely to lead to better outcomes for the population. We provide a full account of how our models function, and how they can be used to explore many different aspects of contagion, including experimenting with different lockdown measures, with connectivity between places, with the tracing of disease clusters and the use of improved contact tracing and isolation. We provide comprehensive results showing the use of these models in given scenarios, and conclude that explicitly regionalised models for mitigation provide significant advantages over a 'one size fits all' approach. We have made our models, and their data, publicly available for others to use in their own locales, with the hope of providing the tools needed for geographers to have a voice during this difficult time.The aim of this paper is to track down elements of self-regulated learning in a massive open online course regarding social capital. Specifically, the study is oriented to explore the relationship between feeling of belonging to an online community and individual and collective regulation of learning. For this aim, a combination of two already tested scales was operated, adapted for the research interests of this study and administered to a sample of MOOC participants. Several structural equation modelling analyses demonstrate that co- and self-regulated learning strategies lead to MOOC achievement (final exam score), and social capital is only a moderator of co-regulated learning (collective evaluation of content and collective decision-making) but not for self-regulated learning (individual environment control).