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Finally, several experiments and a case study were implemented to evaluate the effectiveness and performance of the proposed MCNMF model. The results indicated that our method could reliably and effectively predict disease-associated miRNAs.Identifying essential genes in comparison states (EGS) is vital to understanding cell differentiation, performing drug discovery, and identifying disease causes. Here, we present a machine learning method termed Prediction of Essential Genes in Comparison States (PreEGS). To capture the alteration of the network in comparison states, PreEGS extracts topological and gene expression features of each gene in a five-dimensional vector. PreEGS also recruits a positive sample expansion method to address the problem of unbalanced positive and negative samples, which is often encountered in practical applications. Different classifiers are applied to the simulated datasets, and the PreEGS based on the random forests model (PreEGSRF) was chosen for optimal performance. PreEGSRF was then compared with six other methods, including three machine learning methods, to predict EGS in a specific state. On real datasets with four gene regulatory networks, PreEGSRF predicted five essential genes related to leukemia and five enriched KEGG pathways. Four of the predicted essential genes and all predicted pathways were consistent with previous studies and highly correlated with leukemia. With high prediction accuracy and generalization ability, PreEGSRF is broadly applicable for the discovery of disease-causing genes, driver genes for cell fate decisions, and complex biomarkers of biological systems.It is reported that the symptoms of autism spectrum disorder (ASD) could be improved by effective early interventions, which arouses an urgent need for large-scale early identification of ASD. Until now, the screening of ASD has relied on the child psychiatrist to collect medical history and conduct behavioral observations with the help of psychological assessment tools. Such screening measures inevitably have some disadvantages, including strong subjectivity, relying on experts and low-efficiency. With the development of computer science, it is possible to realize a computer-aided screening for ASD and alleviate the disadvantages of manual evaluation. In this study, we propose a behavior-based automated screening method to identify high-risk ASD (HR-ASD) for babies aged 8-24 months. The still-face paradigm (SFP) was used to elicit baby's spontaneous social behavior through a face-to-face interaction, in which a mother was required to maintain a normal interaction to amuse her baby for 2 minutes (a baseline episode) and then suddenly change to the no-reaction and no-expression status with 1 minute (a still-face episode). Here, multiple cues derived from baby's social stress response behavior during the latter episode, including head-movements, facial expressions and vocal characteristics, were statistically analyzed between HR-ASD and typical developmental (TD) groups. An automated identification model of HR-ASD was constructed based on these multi-cue features and the support vector machine (SVM) classifier; moreover, its screening performance was satisfied, for all the accuracy, specificity and sensitivity exceeded 90% on the cases included in this study. The experimental results suggest its feasibility in the early screening of HR-ASD.Retinal prostheses aim at restoring partial sight to patients that are blind due to retinal degenerative diseases by electrically stimulating the surviving healthy retinal neurons. Ideally, the electrical stimulation of the retina is intended to induce localized, focused, percepts only; however, some epiretinal implant subjects have reported seeing elongated phosphenes in a single electrode stimulation due to the axonal activation of retinal ganglion cells (RGCs). This issue can be addressed by properly devising stimulation waveforms so that the possibility of inducing axonal activation of RGCs is minimized. While strategies to devise electrical stimulation waveforms to achieve a focal RGCs response have been reported in literature, the underlying mechanisms are not well understood. This article intends to address this gap; we developed morphologically and biophysically realistic computational models of two classified RGCs D1-bistratified and A2-monostratified. Computational results suggest that the sodium channel band (SOCB) is less sensitive to modulations in stimulation parameters than the distal axon (DA), and DA stimulus threshold is less sensitive to physiological differences among RGCs. Therefore, over a range of RGCs distal axon diameters, short-pulse symmetric biphasic waveforms can enhance the stimulation threshold difference between the SOCB and the DA. Appropriately designed waveforms can avoid axonal activation of RGCs, implying a consequential reduction of undesired strikes in the visual field.The real-time simulation of large-scale subthalamic nucleus (STN)-external globus pallidus (GPe) network model is of great significance for the mechanism analysis and performance improvement of deep brain stimulation (DBS) for Parkinson's states. This paper implements the real-time simulation of a large-scale STN-GPe network containing 512 single-compartment Hodgkin-Huxley type neurons on the Altera Stratix IV field programmable gate array (FPGA) hardware platform. At the single neuron level, some resource optimization schemes such as multiplier substitution, fixed-point operation, nonlinear function approximation and function recombination are adopted, which consists the foundation of the large-scale network realization. At the network level, the simulation scale of network is expanded using module reuse method at the cost of simulation time. The correlation coefficient between the neuron firing waveform of the FPGA platform and the MATLAB software simulation waveform is 0.9756. Under the same physiological time, the simulation speed of FPGA platform is 75 times faster than the Intel Core i7-8700K 3.70 GHz CPU 32GB RAM computer simulation speed. In addition, the established platform is used to analyze the effects of temporal pattern DBS on network firing activities. The proposed large-scale STN-GPe network meets the need of real time simulation, which would be rather helpful in designing closed-loop DBS improvement strategies.We introduce MulayCap, a novel human performance capture method using a monocular video camera without the need for pre-scanning. The method uses "multi-layer" representations for geometry reconstruction and texture rendering, respectively. For geometry reconstruction, we decompose the clothed human into multiple geometry layers, namely a body mesh layer and a garment piece layer. The key technique behind is a Garment-from-Video (GfV) method for optimizing the garment shape and reconstructing the dynamic cloth to fit the input video sequence, based on a cloth simulation model effectively solved with gradient descent. For texture rendering, we decompose each input image frame into a shading layer and an albedo layer, and propose a method for fusing an albedo map and solving for detailed garment geometry using the shading layer. Compared with existing single view human performance capture systems, our "multi-layer" approach bypasses the tedious and time consuming scanning step for obtaining a human specific mesh template. Experimental results demonstrate that MulayCap produces realistic rendering of dynamically changing details that has not been achieved in any previous monocular video camera systems. Benefiting from its fully semantic modeling, MulayCap can be applied to various important editing applications, such as cloth editing, re-targeting, relighting, and AR applications.We propose a deep-learning based annotation-efficient framework for vessel detection in ultra-widefield (UWF) fundus photography (FP) that does not require de novo labeled UWF FP vessel maps. Our approach utilizes concurrently captured UWF fluorescein angiography (FA) images, for which effective deep learning approaches have recently become available, and iterates between a multi-modal registration step and a weakly-supervised learning step. In the registration step, the UWF FA vessel maps detected with a pre-trained deep neural network (DNN) are registered with the UWF FP via parametric chamfer alignment. The warped vessel maps can be used as the tentative training data but inevitably contain incorrect (noisy) labels due to the differences between FA and FP modalities and the errors in the registration. In the learning step, a robust learning method is proposed to train DNNs with noisy labels. The detected FP vessel maps are used for the registration in the following iteration. The registration and the vessel detection benefit from each other and are progressively improved. Once trained, the UWF FP vessel detection DNN from the proposed approach allows FP vessel detection without requiring concurrently captured UWF FA images. We validate the proposed framework on a new UWF FP dataset, PRIME-FP20, and on existing narrow-field FP datasets. [https://www.selleckchem.com/products/oxalacetic-acid.html selleckchem] Experimental evaluation, using both pixel-wise metrics and the CAL metrics designed to provide better agreement with human assessment, shows that the proposed approach provides accurate vessel detection, without requiring manually labeled UWF FP training data.The most frequent extracranial solid tumors of childhood, named peripheral neuroblastic tumors (pNTs), are very challenging to diagnose due to their diversified categories and varying forms. Auxiliary diagnosis methods of such pediatric malignant cancers are highly needed to provide pathologists assistance and reduce the risk of misdiagnosis before treatments. In this paper, inspired by the particularity of microscopic pathology images, we integrate neural networks with the texture energy measure (TEM) and propose a novel network architecture named DetexNet (deep texture network). This method enforces the low-level representation pattern clearer via embedding the expert knowledge as prior, so that the network can seize the key information of a relatively small pathological dataset more smoothly. By applying and finetuning TEM filters in the bottom layer of a network, we greatly improve the performance of the baseline. We further pre-train the model on unlabeled data with an auto-encoder architecture and implement a color space conversion on input images. Two kinds of experiments under different assumptions in the condition of limited training data are performed, and in both of them, the proposed method achieves the best performance compared with other state-of-the-art models and doctor diagnosis.This article explores the relatively underexplored potential for physicalizations to materialize qualitative data related to human experiences and knowledge domains. Our reading of "data" in this context extends from imperceptible systems and infrastructures to mental models and the phenomenological dimensions of experiences themselves. Physical objects can be regarded as a form of knowledge with which to inquire about human life, bring about improved conditions, and imagine alternative realities. Objects are made of materials, which are manipulated materials into various configurations. The materials used in the process of externalization have a profound influence on the resulting forms, and through them on how knowledge is constructed and internalized. We pay detailed attention to the characteristics of materials and how they are combined, in the context of interdisciplinary exchange. We are motivated by the need for a shared understanding of what work materials can do in the making of physicalisations. We suggest this work is useful in the analysis of physicalizations, specifically where they seek to articulate the phenomena of lived experience.