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CKLF Like Marvel Transmembrane Domain Containing 1 (CMTM1) plays a role in breast cancer and lung cancer, but studies on the occurrence and development of CMTM1 in hepatocellular carcinoma (HCC) have not been reported.<br /><br /> The Cancer Genome Atlas (TCGA) database and immunohistochemistry (IHC) were used to detect CMTM1 expression in HCC tissues. The relationship between CMTM1 expression and the clinicopathological characteristics of HCC patients was analyzed by chi-square test, and the relationship between CMTM1 expression and the prognosis of HCC patients was tested by the Kaplan-Meier model.<br /><br /> Bioinformatics analysis showed that the mRNA expression of CMTM1 was upregulated in HCC tissues, and low expression of CMTM1 is associated with longer disease-free survival in patients with HCC. Similarly, the survival time of HCC patients in CMTM1 high expression group was significantly shorter than that in CMTM1 low expression group. IHC detection indicated that CMTM1 protein was highly expressed in both HCC and adjacent non-tumor tissues, with a positive expression in 84% (63/75) of HCC tissues and 89.3% (67/75) of adjacent non-tumor tissues. Moreover, CMTM1 expression was related to family history and TNM stage of HCC patients (<br /><br /> &lt; 0.05), but had no relationship with other clinicopathological characteristics. The survival analysis based on IHC results showed that the prognosis of HCC patients in CMTM1 negative group was significantly poorer than that in CMTM1 positive group (<br /><br /> &lt; 0.05).<br /><br /> CMTM1 has a high expression in HCC tissues and is related to the prognosis of HCC patients.<br /><br />CMTM1 has a high expression in HCC tissues and is related to the prognosis of HCC patients.<br /><br /> Substantial studies have demonstrated that left atrial (LA) enlargement was a robust predictor of atrial fibrillation (AF) and obesity was a modifiable risk factor for cardiovascular diseases. However, the role of body mass index (BMI) on LA dimension in hypertrophic obstructive cardiomyopathy (HOCM) remains unclear.<br /><br /> A total of 423 HOCM patients (average BMI 25.4 ± 3.4 kg/m<br /><br /> ) were recruited for our study. Participants were stratified into three groups based on BMI normal weight (BMI &lt; 23 kg/m<br /><br /> ), overweight (BMI 23-27.5 kg/m<br /><br /> ), and obesity (BMI ≥ 27.5 kg/m<br /><br /> ).<br /><br /> Compared with normal weight, patients with obesity had significantly lower prevalence of syncope (<br /><br /> = 0.007) and moderate or severe mitral regurgitation (<br /><br /> = 0.014), and serum NT-proBNP (<br /><br /> = 0.004). Multiple linear regression analysis indicated that BMI (<br /><br /> = 0.328, <br /><br /> &lt; 0.001), log NT-proBNP (<br /><br /> = 0.308, <br /><br /> &lt; 0.001), presence of AF (<br /><br /> = 0.209, <br /><br /> = 0.001), and left ventricular diastolic diameter index (<br /><br /> = 0.142, <br /><br /> = 0.019) were independently related with LA diameter. However, BMI was not an independent predictor of the presence of AF on multivariable binary logistical regression analysis.<br /><br /> BMI was independently associated with LA diameter; however, it was not an independent predictor of prevalence of AF. These results suggest that BMI may promote incidence of AF through LA enlargement in HOCM.<br /><br />BMI was independently associated with LA diameter; however, it was not an independent predictor of prevalence of AF. These results suggest that BMI may promote incidence of AF through LA enlargement in HOCM.<br /><br /> The impact of smoking on spinal surgery has been studied extensively, but few investigations have focused on minimally invasive surgery (MIS) of the spine and the difference between complication rates in smokers and non-smokers. [https://www.selleckchem.com/products/nazartinib-egf816-nvs-816.html read more] We evaluated whether a history of at least one pack-year preoperatively could be used to predict adverse peri- and postoperative outcomes in patients undergoing minimally invasive fusion procedures of the lumbar spine. In a prospective study, we assessed the clinical effectiveness of MIS in an unselected population of 187 patients.<br /><br /> We evaluated perioperative and postoperative complication rates in MIS fusion techniques of the lumbar spine in smoking and non-smoking patients. MIS fusion was performed using interbody fusion procedures and/or posterolateral fusion alone.<br /><br /> Smokers were significantly younger than non-smokers. We did not encounter infection at the site of surgery or severe wound healing disorder in smokers. We registered no difference between the smoking and non-smoking groups with regard to peri- or postoperative complication rate, blood loss, or length of stay in hospital. We found a significant influence of smoking (<br /><br /> = 0.049) on the overall perioperative complication rate.<br /><br /> MIS fusion techniques seem to be a suitable tool for treating degenerative spinal disorders in smokers.<br /><br />MIS fusion techniques seem to be a suitable tool for treating degenerative spinal disorders in smokers.<br /><br /> Autologous stem cell transplantation (ASCT) is one of the standard treatments of choice for eligible multiple myeloma (MM) patients. Herein, we aimed to analyze MM patients at our center and compare the clinical outcomes of single and double ASCT patients.<br /><br /> Patients who were diagnosed as having MM and had undergone single or double ASCT in our clinic between the years 2003 and 2020 were retrospectively examined.<br /><br /> In this study, the median time of second ASCT is approximately 3.6 years from the first ASCT. Overall survival (OS) duration of the single and double transplanted groups was 4,011 ± 266 vs 3,526 ± 326 days, respectively (<br /><br /> 0.33). Progression-free survival (PFS) duration of the single and double transplanted groups was 2,344 ± 228 vs 685 ± 120 days, respectively (<br /><br /> 0.22). Disease assessment after ASCT stable or progressive disease, partial remission, and very good partial or complete remission (CR) in single and double ASCT groups was 62/44/105 and 8/4/5, respectively (<br /><br /> 0.22).<br /><br /> The present study points out that the second ASCT treatment option for MM patients may not be effective as suggested, especially in the era of novel MM drugs, since our results come from the past data that novel drugs were not exist. In conclusion, we found no benefit with second ASCT in MM patients in terms of PFS and OS or CR rates, and the novel anti-myeloma drugs might decrease the need for a second transplant.<br /><br />The present study points out that the second ASCT treatment option for MM patients may not be effective as suggested, especially in the era of novel MM drugs, since our results come from the past data that novel drugs were not exist. In conclusion, we found no benefit with second ASCT in MM patients in terms of PFS and OS or CR rates, and the novel anti-myeloma drugs might decrease the need for a second transplant.