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Both groups showed reductions in daytime sleepiness and fatigue, improved well-being by patient global assessment, and high therapeutic acceptance with 98% and 94% of PAP-treated and PAP-naïve patients indicating they would undergo the implant again. Stimulation produced discomfort in approximately one-third of patients, yet &lt;5% of prior PAP-treated participants discontinued therapy.<br /><br /> Polysomnographic and clinical responses to TPNS were comparable in PAP-naïve and prior PAP-treated CSA patients. TPNS is a viable therapy across a broad spectrum of CSA patients.<br /><br /> ClinicalTrials.gov Identifier NCT01816776; March 22, 2013.<br /><br />ClinicalTrials.gov Identifier NCT01816776; March 22, 2013.<br /><br /> To lay the fundamentals of drug-related problems (DRPs) in older adults, and to organize them according to a logical process conciliating medical and pharmaceutical approaches, to better identify the causes and consequences of DRPs.<br /><br /> A narrative overview.<br /><br /> The causes of DRPs may be intentional or unintentional. They lie in poor prescription, poor adherence, medication errors (MEs) and substance use disorders (SUD). Poor prescription encompasses sub-optimal or off-label drug choice; this choice is either intentional or unintentional, often within a polypharmacy context and not taking sufficiently into account the patient's clinical condition. Poor adherence is often the consequence of a complicated administration schedule. This review shows that MEs are not the most frequent causes of DRPs. SUD are little studied in older adults and needs to be more investigated because the use of psychoactive substances among older people is frequent. Prescribers, pharmacists, nurses, patients, and caregivers all play a role in different causes of DRPs. The potential deleterious outcomes of DRPs result from adverse drug reactions and therapeutic failures. These can lead to a negative benefit-risk ratio for a given treatment regimen.<br /><br /> Interdisciplinary pharmacotherapy programs show significant clinical impacts in preventing or resolving adverse drug events and, suboptimal responses. New technologies also seem to be interesting solutions to prevent MEs. Better communication between healthcare professionals, patients and their caregivers would ensure greater safety and effectiveness of treatments.<br /><br />Interdisciplinary pharmacotherapy programs show significant clinical impacts in preventing or resolving adverse drug events and, suboptimal responses. New technologies also seem to be interesting solutions to prevent MEs. Better communication between healthcare professionals, patients and their caregivers would ensure greater safety and effectiveness of treatments.<br /><br /> SCD patients experience declines in health-related quality of life (HRQOL) domains compared with healthy controls. Despite evidence supporting thebenefits of hydroxyurea, medication non-adherence remains problematic, especially in adolescents and young adults (AYA). Adherence barriers includeforgetfulness and lack of knowledge. Recently, increased interest in technology-based strategies to improve medication adherence has emerged. No datacurrently exists on hydroxyurea adherence, HRQOL or perceptions of technology-based tools in the Irish SCD population.<br /><br /> In order to interrogate these domains among Irish AYA SCD patients we administered an anonymous survey at two tertiary referral centres in Dublin, Ireland, inJuly 2019.<br /><br /> Sixty-three patients participated; 63% female and 37% male, with a median and mean age of 17 and 19 years, respectively. Average monthly adherence was76% using a visual analogue scale. Recall barriers were present in 62% while 26% omit hydroxyurea for reasons other than forgetting. Revien adherence in SCD and other chronic health conditions.Jump locomotion is the basic movement of human. However, no thorough research on the recognition of jump sub-phases has been carried so far. This paper aims to use multi-sensor information fusion and machine learning to recognize the human jump phase, which is crucial to the development of exoskeleton that assists jumping. The method of information fusion for sensors including sEMG, IMU, and footswitch sensor is studied. The footswitch signals are filtered by median filter. A processing method of synthesizing Euler angles into phase angle is proposed, which is beneficial to data integration. The jump locomotion is creatively segmented into five phases. The onset and offset of active segment are detected by sample entropy of sEMG and standard deviation of acceleration signal. The features are extracted from analysis windows using multi-sensor information fusion, and the dimension of feature matrix is selected. [https://www.selleckchem.com/products/blu-554.html FGFR inhibitor] By comparing the performances of state-of-the-art machine learning classifiers, feature subsets of sEMG, IMU, and footswitch signals are selected from time domain features in a series of analysis window parameters. The average recognition accuracy of sEMG and IMU is 91.76% and 97.68%, respectively. When using the combination of sEMG, IMU, and footswitch signals, the average accuracy is 98.70%, which outperforms the combination of sEMG and IMU (97.97%, p less then  0.01). Graphical Abstract The sub-phases of human locomotion are recognized based on multi-sensor information fusion and machine learning method. The feature data of the sub-phases is visualized in 3-dimensional space. The predicted states and the true states in a complete jump are compared along the time axis.Ischemic stroke is one of the most common and undertreated cerebral diseases with high mortality and disability rate. Various intrinsic and extrinsic factors regulate the onset, severity, and progression of ischemic stroke. As an integral part of the neuronal glia system, astrocytes provide many housekeeping functions in nervous system, and perform multiple functions both beneficial and detrimental for neuronal survival after ischemic stroke. In addition, the small GTPase Rho and its downstream Rho kinase (ROCK) are associated with various neuronal functions such as dendrite development, migration and axonal extension, and numerous central nervous system (CNS) diseases. The aim of this review is to summarize the role of RhoA/ROCK signaling pathway and astrocytes on neurological function after ischemic stroke. We also discuss the interaction of RhoA/ROCK signaling pathway and astrocytes on the tissue repair after brain injury.