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Atrial fibrillation (AF) is a prevalent arrhythmia and the leading preventable cause of cardioembolic stroke. Scoring systems for predicting AF risk do not use imaging modalities. We sought to determine whether LA longitudinal strain could be used as a single parameter for predicting the risk of AF.<br /><br /> Consecutive patients diagnosed with diastolic dysfunction between December 2019 and March 2020 were included. Two-dimensional, colour flow, continuous pulse-wave, and tissue Doppler transthoracic echocardiography (TTE) were performed using a Vivid E9 imaging system (GE Medical Systems, Chicago, USA). Measurements were obtained in the standard manner recommended by the American Society of Echocardiography. Moreover, LA longitudinal strain was measured using 2D speckle tracking echocardiography in the four-chamber view to evaluate left atrial function. The CHARGE-AF scoring system was used to predict AF risk.A total of 148 patients (mean age 57.6 ± 11.9; male 53%) with feasible views for LA strain measurement were divided into two groups based on a 10% CHARGE-AF cut-off score. The &gt;10% group (48 patients; 32%) was defined as having a predicted 5-year AF risk &gt;10%, and the ≤10% group (100 patients; 68%) was defined as having a predicted risk &lt;10%. In the multivariate analysis, LA reservoir strain (LASr) was independently associated with CHARGE-AF score. Furthermore, using the Pearson correlation method, LASr was found to be highly correlated with CHARGE-AF score (<br /><br />  = -0.74, <br /><br />  &lt; 0.0001).<br /><br /> LASr was highly correlated with CHARGE-AF risk score and may be used as a parameter to predict atrial myopathy and hence AF risk.<br /><br />LASr was highly correlated with CHARGE-AF risk score and may be used as a parameter to predict atrial myopathy and hence AF risk.<br /><br /> This study has been conducted to test the Turkish Validity and Reliability of the Age-Friendly Cities and Communities Questionnaire.<br /><br /> This methodological research has been carried out in a health center in Istanbul between January and April 2021. Between the specified dates, 306 older adults who met the research criteria within the population of the research, who accepted to participate and returned the filled-out questionnaires have been included in the study. The items of the scale are scored between -2, 2 and the scale consists of 20 items and 8 sub-dimensions. After the scale was translated, the content and structure validity tests were carried out.<br /><br /> As a result of the evaluations and analyses, the content validity index of the scale was found to be 0.96. In the explanatory factor analysis conducted in the adaptation of the scale to Turkish, the total variance rate explained was found to be 92.36%. The factor loads of all items ranged between 0.71 and 0.91. The Cronbach Alpha values of the sub-dimensions of the scale ranged from .899 to .969, and the total Cronbach Alpha value was determined as .954. EFA and CFA results showed that the scale consists of 8 sub-dimensions with 20 items and the factor structure is sufficient. Good coherence index values were obtained as a result of CFA.<br /><br /> The Turkish version of the Age-Friendly Cities and Communities Questionnaire is a valid and reliable measurement tool to evaluate age-friendly practices in an area where older adults live.<br /><br />The Turkish version of the Age-Friendly Cities and Communities Questionnaire is a valid and reliable measurement tool to evaluate age-friendly practices in an area where older adults live.<br /><br /> Age-friendly planning should not fall to local departments of senior services only.Planning coordination of age-friendly policy results in more diverse outcomes.Mapping is a tool helping policy makers visualize alternative opportunities.Maps give stakeholders the ability to track and monitor progress.This approach is easily replicable for cities implementing age-friendly programs.<br /><br />Age-friendly planning should not fall to local departments of senior services only.Planning coordination of age-friendly policy results in more diverse outcomes.Mapping is a tool helping policy makers visualize alternative opportunities.Maps give stakeholders the ability to track and monitor progress.This approach is easily replicable for cities implementing age-friendly programs.Objectives. Occupational activities in open spaces can experience excessive heat exposure caused by sunlight and other artificial sources in these professional environments can be one of the current and future challenges of occupational safety and health due to increasing global warming. Use of lightweight portable parasols is the first available control measure to reduce the radiation emitted by the sun in outdoor workplaces, which has been used for a long time. Methods. Due to the lack of study and results on the effect of using parasols in scientific literature, this modeling study was conducted to investigate the effect of sunshade installation on radiant temperature reduction of the sun in outdoor work using COMSOL Multiphysics version 5.5. Results. In general, six different shapes of portable parasols in different positions were modeled and the average radiant temperature reduction effectiveness (TRE) was about 30% in the presence of different parasols. The designed conical, simple and pyramidal sunshades showed the most effectiveness, respectively. Conclusions. The results show that changing variables such as the axis, installation height and shape is more effective for improving parasol efficiency to reduce the radiant temperature below it.<br /><br /> Neonatal hypoxic-ischemic encephalopathy (HIE) endangers quality of life in children, and curative attempts are rarely effective. [https://www.selleckchem.com/products/LBH-589.html HDAC inhibitor] Neurogenesis plays an important role in neural repair following brain damage. This study aimed to investigate the role of telomerase reverse transcriptase (TERT) in neurogenesis after neonatal hypoxic-ischemic brain damage (HIBD).<br /><br /> Neonatal HIBD models were established <br /><br /> (Sprague-Dawley rats, 7days old) and <br /><br /> (cultured neural stem cells, NSCs). Lentivirus and adenovirus transfection was used to induce TERT overexpression. Expression of TERT was detected by quantitative real-time PCR and immunofluorescence staining. NSCs apoptosis and proliferation were measured by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining and cell counting assays, respectively. Migration and differentiation of NSCs were assessed by western blotting and immunofluorescence staining. Morris water maze test and modified neurological severity scores were conducted to evaluate the neonatal HIE. Furthermore, TERT may represent a target during neural injury and repair in patients with various diseases affecting the nervous system.<br /><br /> The number of Accountable Care Organizations (ACOs) in the U.S. has been rapidly increasing during the past decade. Despite the growth of Accountable Care Organizations (ACOs), little is known about the factors that are associated with hospital leadership of ACOs that contract with public and private payers.<br /><br /> Using a resource dependency framework, this study examines the organizational characteristics and environmental factors that are associated with hospitals who are leading an ACO.<br /><br /> We used the data from the American Hospital Association (AHA) Annual Survey of Hospitals for 2018, the Area Health Resources Files and the Medicare Cost Reports. A multiple logistic regression was used to test associations of the independent variables with the hospital leadership of ACOs.<br /><br /> We found that nearly one third of the hospitals studied were leading an ACO. System affiliated and not-for-profit hospitals were more likely to be the leaders. Hospitals that lead an ACO offer more clinical services and have better financial performance. Metropolitan core-based statistical areas and per capita income were significantly positively associated with leading an ACO. However, the proportion of population aged 65 and over and the percentage of Medicare advantage penetration were significantly negatively associated with leading an ACO.<br /><br /> Hospitals vary in leading an ACO, which may provide critical resources for them by creating an infrastructure that enables accountable care, extends their services into population health and value-based care programs increasingly promoted by public and commercial payers.<br /><br />Hospitals vary in leading an ACO, which may provide critical resources for them by creating an infrastructure that enables accountable care, extends their services into population health and value-based care programs increasingly promoted by public and commercial payers.Competitive skiers encounter a high risk of sustaining an ACL injury during jump-landing in downhill ski racing. Facing an injury-prone landing manoeuvre, there is a lack of knowledge regarding optimum control strategies. So, the purpose of the present study was to investigate possible neuromuscular control patterns to avoid injury during injury-prone jump-landing manoeuvres. A computational approach was used to generate a series of 190 injury-prone jump-landing manoeuvres based on a 25-degree-of-freedom sagittal plane musculoskeletal skier model. Using a dynamic optimization framework, each injury-prone landing manoeuvre was resolved to identify muscle activation patterns of the lower limbs and corresponding kinematic changes that reduce peak ACL force. In the 190 injury-prone jump-landing simulations, ACL forces peaked during the first 50 ms after ground contact. Optimized muscle activation patterns, that reduced peak ACL forces, showed increased activation of the monoarticular hip flexors, ankle dorsi- andplitude) of muscles crossing the knee as well as the hip and ankle joints prior to and after initial ground contact, respectively.An optimized control strategy during an injury-prone landing manoeuvre was characterized kinematically by increasing hip and knee flexion and less backward lean of the skier at initial ground contact and the following impact phase.This study examined cardiovascular, perceptual and neuromuscular fatigue characteristics during and after cycling intervals with and without blood flow restriction (BFR). Fourteen endurance cyclists/triathletes completed four 4-minute self-paced aerobic cycling intervals at the highest sustainable intensity, with and without intermittent BFR (60% of arterial occlusion pressure). Rest interval durations were six, four and four minutes, respectively. Power output, cardiovascular demands and ratings of perceived exertion (RPE) were averaged over each interval. Knee extension torque and vastus lateralis electromyography responses following electrical stimulation of the femoral nerve were recorded pre-exercise, post-interval one (+1, 2 and 4-minutes) and post-interval four (+1, 2, 4, 6 and 8-minutes). Power output during BFR intervals was lower than non-BFR (233 ± 54 vs 282 ± 60 W, p  less then  0.001). Oxygen uptake and heart rate during BFR intervals were lower compared to non-BFR (38.7 ± 4.5 vs 44.7 ± 6.44 mL kBFR) during self-paced intervals (at the highest perceived sustainable intensity) causes a reduction in power output, pulmonary oxygen uptake and heart rate compared with non-restricted self-paced intervals.Despite lower mechanical and physiological demands during BFR cycling, the magnitude and aetiology of neuromuscular fatigue were not different to intervals without BFR, indicating the internal muscular load during BFR was elevated and potentially equivalent compared to without BFR.Self-paced intervals could be a suitable model to prescribe aerobic BFR exercise as an adjunct training stimulus for endurance cyclists.