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Taken together, the results of our study indicate that the circ_0050463 promotes IAV replication via miR-33b-5p/EEF1A1 axis, thus providing evidence for the host circRNAs utilized by viruses to support their replication.The cross sections of the 180Hf(n,p)180Lu and 90Zr(n,2n)89mZr reactions were measured around the neutron energies of 13.5-14.8 MeV by using the activation technique. The excitation functions of the above reactions in the neutron energies from the threshold to 20 MeV were calculated by using the nuclear theoretical model program system Talys-1.9 with the adjusted relevant parameters. The measured results were discussed and compared with previous experiments by other researchers and with the evaluated data of ENDF/B-VIII.0, CENDL-3.1, JEFF-3.3, JENDL-4.0u2, BROND-3.1 as well as the theoretical values based on Talys-1.9. The obtained experimental values at some neutron energies, within experimental error, are consistent with those of the fitting line of the results of previous experiments and are also consistent with those of theoretical excitation curve at the corresponding energies. The obtained theoretical excitation curves match well with most of the experimental data.Androgenic alopecia (AGA), also known as male pattern baldness, is one of the most common hair loss diseases worldwide. The main treatments of AGA include hair transplant surgery, oral medicines, and LDL laser irradiation, although no treatment to date can fully cure this disease. Animal models play important roles in the exploration of potential mechanisms of disease development and in assessing novel treatments. The present study describes androgen receptor (AR) in C57BL/6 mouse hair follicles that can be activated by dihydrotestosterone (DHT) and translocate to the nucleus. This led to the design of a mouse model of androgen-induced AGA in vivo and in vitro. DHT was found to induce early hair regression, hair miniaturization, hair density loss, and changes in hair morphology in male C57BL/6 mice. These effects of DHT could be partly reversed by the AR antagonist bicalutamide. DHT had similar effects in an ex vivo model of hair loss. Evaluation of histology, organ culture, and protein expression could explain the mechanism by which DHT delayed hair regrowth.Oxidative stress and inflammation are important pathogenic factors of diabetic retinopathy (DR). DR remains the most common ocular complication caused by diabetes mellitus (DM) and is the leading cause of visual impairment in working-aged people worldwide. Melatonin has attracted extensive attention due to its potent antioxidant and anti-inflammatory effects. [https://www.selleckchem.com/products/4-hydroxytamoxifen-4-ht-afimoxifene.html Afimoxifene Estrogen modulator] In the present study, melatonin inhibited oxidative stress and inflammation by enhancing the expression and activity of silent information regulator factor 2-related enzyme 1 (Sirt1) both in in vitro and in vivo models of DR, and the Sirt1 inhibitor EX-527 counteracted melatonin-mediated antioxidant and anti-inflammatory effects on Müller cells. Moreover, melatonin enhanced Sirt1 activity through the maternally expressed gene 3 (MEG3)/miR-204 axis, leading to the deacetylation of the Sirt1 target genes forkhead box o1 (Foxo1) and nuclear factor kappa B (NF-κB) subunit p65, eventually contribute to the alleviation of oxidative stress and inflammation. The study revealed that melatonin promotes the Sirt1 pathway, thereby protecting the retina from DM-induced damage.Cerebral ischemia-reperfusion injury can lead to a series of serious brain diseases and cause death or different degrees of disability. Polysaccharide is a kind of biological macromolecule with multiple pharmacological activities and has been proven that it may be used for the treatment of cerebral I/R injury in the future. By sorting out all relevant research from 2000 to 2020, we selected 74 references and identified 22 kinds of polysaccharides. Almost all of these polysaccharides are extracted from traditional Chinese medicine. Research shows that these polysaccharides can improve cerebral ischemia-reperfusion injury through anti-oxidative stress, inhibiting the neuroinflammation, glutamate neurotoxicity and neuronal apoptosis, and exerting neurotrophic effect. The specific mechanisms include clearing ROS and RNS, inhibiting the expression of inflammatory factors, maintaining mitochondrial homeostasis and blocking caspase cascade, regulating NMDA receptor and promoting angiogenesis. We hoped this review is instructive for researchers to design, research and develop polysaccharides.Photodynamic Therapy (PDT) has been known for over a hundred years, and currently gaining in acceptance as an alternative cancer treatment. Light delivery is still a difficult problem in deep cancer treatment with PDT. Only near-infrared light in the 700-1100 nm range can penetrate deeply into the tissue because most tissue chromophores, including oxyhemoglobin, deoxyhemoglobin, melanin and fat, poorly absorb in the near infrared window. The light sources used in PDT are lasers, arc lamps, light-emitting diodes and fluorescent lamps. PDT has been used for many different clinical applications. PDT may be excellent alternative in the treatment and diagnosis of breast cancer compared to the conventional surgery, chemotherapy and radiotherapy. The basic elements of PDT are an appropriate photosensitizer (PS), oxygen, and light. The effectiveness of photodynamic therapy depends on the induction of photocytotoxic reactions, which are the result of light activation of PS), pre-administered to the body. The condition for initiating PDT processes is light absorption by PS and subsequent localized generation of cytotoxic reactive oxygen species. This study is a review of empirical research aimed at improving the therapy and diagnosis of breast cancer using PDT based on the physicochemical differences in healthy and diseased tissues and the tissues undergoing treatment.Osteoarthritis (OA), manifested as degeneration and damage of the articular cartilage is a progressive disease of joints. Previous studies have shown that extracellular matrix degradation and inflammation have quite a significant performance in the occurrence and development of OA. In various maladies, an anti-inflammatory effect has been demonstrated for Xanthohumol (XN); while OA is an inflammation related disease. The current in vivo and in vitro study aimed to investigate the therapeutic effect of XN on OA as well as its working mechanism. The results showed that XN has the capability to hinder the expression of nitric oxide synthase (INOS), IL-1β-promoted inducible nitric oxide (NO), necrosis factor-α of tumor (TNF-α), interleukin-6 (IL-6), and cyclooxygenase-2 (COX-2) in vitro. In addition, XN has been found to down-regulate the expression of matrix metalloproteinase-13 and prothrombin stimulated by IL-1β and up-regulates type II collagen and Aggrecan expression. At the same time, it was discovered that XN activates nuclear factor (Nrf2) in chondrocytes stimulated by IL-1β and inhibits nuclear factor B (NF-кB) signal transduction.