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At the last follow-up visit, anatomical success was achieved in 40 (90.9%) cases and the BCVA of more than half of the patients was over 1.0 (logMAR, n = 24, 54.5%). Most commonly seen complication was found to be secondary glaucoma (n = 19, 43.2%), followed by cataracts (n = 9, 34.6%) and graft rejection (n = 12, 27.3%).<br /><br /> TPKP offers a definitive solution in the management of microbial keratitis with high rates of anatomical and functional success. However, secondary glaucoma is the most common complication after TPKP, which was seen in almost half of the patients.<br /><br />TPKP offers a definitive solution in the management of microbial keratitis with high rates of anatomical and functional success. However, secondary glaucoma is the most common complication after TPKP, which was seen in almost half of the patients.<br /><br /> To assess the incidence, types, and outcomes of second primary tumors (SPT) in cases of retinoblastoma (RB) from a referral Tertiary eye care center METHODS Retrospective chart review of 7 cases RESULTS All 7 (100%) cases had bilateral RB at presentation. The mean age at diagnosis of RB was 16months (median 7months; range 5-72months). Treatment of RB with intravenous chemotherapy was noted in 3 (43%) patients, 1 (14%) patient had received external beam radiotherapy (EBRT) to the orbit, 1 (14%) patient had received a combination of chemotherapy and orbital EBRT, while 4 (57%) patients had undergone primary enucleation of the worse eye and focal treatment of the better eye. The mean age at detection of SPT was 15years (median 8years; range 6-46years). The mean time interval between diagnosis of RB and SPT was 13years (median 7years; range 1-41years). The SPT's included osteosarcoma of long bone (n = 2), eyelid sebaceous gland carcinoma (n = 2), ventricular ependymoma (n = 1), orbital neuroblastoma (n = 1), and acute lymphoblastic leukemia (n = 1). [https://www.selleckchem.com/products/sis17.html find more] All patients received treatment for the SPT with either surgical excision (n = 2), intravenous chemotherapy (n = 1), or a combination of surgery/chemotherapy/radiotherapy (n = 4). Over a mean follow-up period of 8years (median 8years; range 4-11years), one (14%) patient died, while other 6 (86%) patients are alive and well.<br /><br /> Though the incidence of SPT's in cases of RB is rare, life-long follow-up is mandatory in at-risk patients.<br /><br />Though the incidence of SPT's in cases of RB is rare, life-long follow-up is mandatory in at-risk patients.<br /><br /> To systematic analysis of domestic and foreign literature on the incidence and related factors of glaucomatous optic nerve damage (GOND) in patients with Glaucomatocyclitic Crisis (PSS).<br /><br /> A computerized literature search was carried out in PubMed database, Wanfang Medical Database, China National Knowledge Infrastructure to collected domestic and foreign research studies on the incidence and related factors of glaucomatous optic nerve damage of Glaucomatocyclitic Crisis. Using Stata 15.1 software, select the indicators incidence, gender, age, single/double eyes, duration of disease, and intraocular pressure (IOP) at onset for meta-analysis. OR (odds risk) was used as the effect variable for the binary variables, and mean difference was used as the effect variable for the continuous variables. The results are expressed by each effect amount and its 95% Confidence interval (CI). If there was heterogeneity among the original studies, a random effects model was used; otherwise, a fixed effects model was used.<br /><br /> A total of 13 studies were included. The incidence of GOND in PSS was 0.251 (95%CI 0.175-0.327). Three studies include the relevant factor analysis and the results showed there was a statistically significant difference in age, and duration of disease in PSS patients with/without GOND (p = 0.000, p = 0.000), there was no statistical difference between the two groups in gender, single /double eyes, and IOP at onset (p = 0.468, 0.053, 0.065).<br /><br /> Glaucomatocyclitic Crisis can cause glaucomatous optic nerve damage. GOND is more likely to occur in patients who are older, and have a long course of the disease. For such patients, special attention should be paid to the detailed examination of visual function and follow-up.<br /><br />Glaucomatocyclitic Crisis can cause glaucomatous optic nerve damage. GOND is more likely to occur in patients who are older, and have a long course of the disease. For such patients, special attention should be paid to the detailed examination of visual function and follow-up.<br /><br /> To compare the results of using small incision lenticule extraction (SMILE) and wavefront-guided femtosecond-assisted laser in situ keratomileusis (WFG FS-LASIK) to correct high myopia and myopic astigmatism.<br /><br /> The 94 eyes of 47 patients with high myopia or myopic astigmatism, if not both, who had undergone SMILE were compared with the 94 eyes of 47 patients with high myopia or myopic astigmatism, also if not both, who had undergone WFG FS-LASIK. Only eyes with high myopic or myopic astigmatism errors greater than - 6.0 diopter (D) spherical refraction and 0-3 D cylindrical refraction were included. Values of uncorrected distance visual acuity, corrected distance visual acuity, efficacy index, safety index, predictability, and high-order aberration between the patient groups were compared.<br /><br /> The SMILE and WFG FS-LASIK groups did not significantly differ according to sex or age. Values of preoperative and postoperative spherical refraction, cylindrical refraction, spherical equivalent, uncorrected distance visual acuity, and corrected distance visual acuity between the groups also did not significantly differ nor did values of predictability, the efficacy index, or the safety index. SMILE induced more coma and trefoil (p &lt; 0.001), whereas WFG FS-LASIK induced more spherical aberration (p &lt; 0.001).<br /><br /> Both SMILE and WFG FS-LASIK are efficient, safe, predictable procedures for correcting high myopia and myopic astigmatism. SMILE may induce more coma and trefoil, whereas WFG FS-LASIK may induce more spherical aberration.<br /><br />Both SMILE and WFG FS-LASIK are efficient, safe, predictable procedures for correcting high myopia and myopic astigmatism. SMILE may induce more coma and trefoil, whereas WFG FS-LASIK may induce more spherical aberration.