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Finally, the future PM2.5 concentration is forecasted from 2020 to 2022 using the proposed model, which provides early warning information for policy-makers to develop PM2.5 alleviation strategies.This study analyzed long-term observational data of particulate matter (PM2.5, PM10) variability, gaseous pollutants (CO, NO2, NOX, SO2, and O3), and meteorological factors in 412 fixed monitoring stations from January 2008 to December 2018 in Germany. Based on Hurst index analysis, the trend of atmospheric pollutants in Germany was stable during the research period. The relative correlations of gaseous pollutants and meteorological factors on PM2.5 and PM10 concentrations were analyzed by Back Propagation Neural Network model, showing that CO and temperature had the greater correlations with PM2.5 and PM10. Following that, PM2.5 and PM10 show a strong positive correlation (R2 = 0.96, p less then 0.01), suggesting that the reduction of PM2.5 is essential for reducing PM pollution and enhancing air quality in Germany. Based on typical PM10/CO ratios obtained under ideal weather conditions, it is conducive to roughly estimate the contribution of natural sources. In winter, the earth's crust contributed about 20.1% to PM10. Taken together, exploring the prediction methods and analyzing the characteristic variation of pollutants will contribute an essential implication for air quality control in Germany.Seafood contamination with, and human consumption of, microplastics (MPs) have recently been highlighted as an emerging concern for global food security. While there is evidence that commercial marine species are contaminated with MPs, it is still unknown if seafood can act as a vector for MP transfer to human consumers. Microplastics have been reported in the digestive tract, gills and in select internal organs of marine animals. However, many of these tissues are not typically eaten by human consumers but discarded. In this critical review, we examined the peer-reviewed literature for evidence of MP contamination in seafood, and the potential transfer to human consumers. Based on known seafood consumption patterns in a typical Australian diet, we assessed the relevance and reliability of the current body of literature to examine the prospect and risk of MP transfer. The relevance of data was considered based on the organism studied, origin of the samples, and the tissues analysed, while reliability was assessed based on procedural methodologies used to derive the data. A review of 132 studies found limited evidence of MP contamination in edible tissues from fresh fish or crustaceans. MP presence was confirmed in packaged fish, as well as in fresh and packaged bivalve molluscs. The limited number of studies satisfying the relevance and reliability criteria (n = 24) precluded a quantitative assessment of the potential risk associated with MP transfer. While consumption of packaged fish and bivalve molluscs may result in the consumption of MPs by humans, it is currently unknown whether this presents a health risk.The environmental load of organophosphate ester (OPE) flame retardants has caused a series of problems due to their extensive use. The soil matrix, as an ultimate sink for organic pollution, plays a vital part in the fate of OPEs in the environment. In this study, the spatial occurrence, composition profile and health risk of 13 OPE species in farmland soils from four provinces of China were characterized. Excluding tris(2,3-dibromopropyl) phosphate (TDBPP) and ethylhexyl diphenyl phosphate (EHDPP), the remaining eleven OPEs had a high detection frequency (DF) ranging from 60% to 100%. The range of total OPE (ΣOPE) concentrations were 62.3-394 ng/g dry weight (dw), with a median of 228 ng/g dw. Among these OPEs, tris(2-ethylhexyl) phosphate (TEHP) with a median of 143 ng/g dw) was the predominant species, followed by tricresyl phosphate (TCP; median of 20.1 ng/g dw) and tris(2-chloroethyl) phosphate (TCEP; median of 17.9 ng/g dw). In terms of geographical distribution, significantly lower OPEs levels were found in samples from Heilongjiang (159 ± 47.0 ng/g dw) than in those of Guangxi (264 ± 66.0 ng/g dw), Henan (252 ± 74.5 ng/g dw) and Hubei (242 ± 52.8 ng/g dw) provinces. Principal component analysis and Spearman's correlations were used to reveal potential sources of OPEs in the different provincial regions. Health risk exposure to OPEs in farmland soils was at an acceptable level ( less then 1.20 × 10-5 for non-carcinogenic risk to children as the most sensitive age group; and less then 6.47 × 10-10 for carcinogenic risk to adults as the most sensitive age group) at the present detected concentrations. However, TCEP and TEHP, the predominant risk contributors, should be paid more attention.In developing countries, where high levels of antimicrobial resistance are observed in hospitals, the surveillance of this phenomenon in wastewater treatment plants (WWTPs) and the environment is very limited, especially using cutting-edge culture-independent methods. In this study, the composition of bacterial communities, the resistome and mobilome (the pool of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs), respectively) at a WWTP were determined using shotgun metagenomics and culture-based approaches. Wastewater samples were collected at four sampling points of a WWTP in Antioquia, Colombia. A total of 24 metagenomes were analyzed. Specifically, there were marked differences in bacterial community composition, resistome, and mobilome, according to the WWTP sampling points. Bacterial families of clinical importance such as Moraxellaceae, Aeromonadaceae, and Enterobacteriaceae were mainly detected in the WWTP influent and effluent samples. Genes encoding resistance to macrolide-lincosamide-streptogramin, β-lactams, and those conferring multidrug resistance (e.g., acrB, adeG, and mexD) were the most abundant. Moreover, some clinically important ARGs such as blaKPC-2 and blaCTX-M, and others not reported locally, such as blaTEM-196, blaGES-23, blaOXA-10, mcr-3, and mcr-5 were frequently detected. [https://www.selleckchem.com/products/pf-06650833.html PF-06650833 inhibitor] Co-occurrence network analyses indicated a significant association of ARGs such as blaOXA-58 and blaKPC genes with Aeromonadaceae and Enterobacteriaceae. Among the markers of MGEs, intI1 and ISCR8 were the most frequently detected. Altogether, this work reveals the importance of shotgun metagenomics and culture-based approaches in antimicrobial resistance studies. The findings also support that WWTPs are hotspots for antimicrobial resistance, whose analysis constitutes a powerful tool to predict the impact of antimicrobial resistance in a population.